[Sister Mary Joseph's nodule: metastatic umbilical carcinoma]. / Nódulo de la Hermana María José: carcinoma umbilical metastásico.

Maria Jose's Sister's lump (metastatic umbilical carcinoma) is a metastasis of more than one malignant tumor (frequently abdominal), but on occasions it is the first sign of disease. A case of a female patient diagnosed as having "umbilical hernia" with peritoneal carcinomatosis, liver metastasis and "frozen pelvis", who died 6 months later, is presented, demonstrating the bad prognosis of this sign.

Premalignant changes in nasal and sinus polyps: a retrospective 10 year study (1979-1988).

One hundred and seventy cases of nasal and/or sinus polyps diagnosed in the Pathology Service of the Hospital Militar Central GOMEZ/ULLA of Madrid (Spain) between 1.9.79 and 1.9.88 are reviewed. In two cases areas of 'carcinoma in situ' in the epithelium covering the polyps were demonstrated. The literature is reviewed for reports of malignant transformation and dysplastic changes in nasal and sinusal polyps. We suggest that precancerous changes may occasionally be noted in inflammatory lesions, a fact that pathologists should keep in mind.