RESUMO
Type 2 diabetes is a disease with an increasing prevalence due to the ageing and sedentary lifestyle of the general population. Its associated with the risk of developing a series of chronic complications in mid/long-term. The current guidelines recommend certain therapy targets that have proven difficult to achieve due to poor compliance or because doctors do not always adhere to expert guidelines. The inability to achieve an adequate glycemic control in the course of diabetes may result in part from the typical conservative stepwise treatment approach that includes monotherapy initiated alter failure of diet and exercise, followed by a combination of oral antiglycemic agents, and ultimately insulin therapy. With respect to insulin therapy, the availability of different analogues as well as the new routes of administration (e.g., inhaled insulin) may allow the early introduction of this therapy, which may be more readily accepted by the patient.
Assuntos
Diabetes Mellitus Tipo 2/tratamento farmacológico , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Árvores de Decisões , Quimioterapia Combinada , Humanos , Insulina/análogos & derivados , Guias de Prática Clínica como AssuntoRESUMO
La diabetes mellitus tipo 2 es una enfermedad cada vez más prevalente por el sedentarismo y el envejecimiento poblacional, y está asociada, a medio-largo plazo, con el riesgo de desarrollar una serie de complicaciones crónicas. Las guías terapéuticas actuales recomiendan objetivos de tratamiento que son inalcanzables para la mayoría de los pacientes, bien por incumplimiento terapéutico o porque el médico no respeta las directrices de los expertos. La incapacidad para alcanzar los adecuados controles glucémicos al inicio del curso evolutivo de la diabetes puede deberse al clásico abordaje conservador y escalonado, que se basa en la monoterapia, tras el fracaso de la dieta y el ejercicio, seguida de tratamiento oral combinado y posterior insulinización sola o en combinación. Con respecto a la insulina, la actual disponibilidad de análogos «a la carta», así como las nuevas formas de administración como la insulina inhalada, puede permitir su introducción temprana sin el rechazo del paciente
Type 2 diabetes is a disease with an increasing prevalence due to the ageing and sedentary lifestyle of the general population. Its associated with the risk of developing a series of chronic complications in mid/long-term. The current guidelines recommend certain therapy targets that have proven difficult to achieve due to poor compliance or because doctors do not always adhere to expert guidelines. The inability to achieve an adequate glycemic control in the course of diabetes may result in part from the typical conservative stepwise treatment approach that includes monotherapy initiated alter failure of diet and exercise, followed by a combination of oral antiglycemic agents, and ultimately insulin therapy. With respect to insulin therapy, the availability of different analogues as well as the new routes of administration (e.g., inhaled insulin) may allow the early introduction of this therapy, which may be more readily accepted by the patient (AU)
