The association between development and progression of multinodular goiter and thyroid-stimulating hormone receptor gene D727E and P52T polymorphisms.

AIM: This study has been performed on a Turkish population with multinodular goiter (MNG) to investigate the thyroid-stimulating hormone receptor (TSHR) gene D727E and P52T polymorphisms. METHODS: DNA samples were isolated from 300 patients with MNG and 142 controls. Polymerase chain reaction-restriction fragment length polymorphism and agarose gel electrophoresis were used. RESULTS: The D727E polymorphism G-allele frequency and the CG and GG genotypes were significantly higher in patients with MNG. However, there was no significant difference in the P52T polymorphism between patients and control subjects. CONCLUSIONS: As a conclusion, the D727E polymorphism G allele may be related to MNG development in the studied population.

[Clinical differences between surgically treated patients with large bowel obstruction in the cities of Van and Istanbul]. / Van ve Istanbul illerinde cerrahi tedavi uygulanan akut kalin barsak tikanmali olgular arasindaki klinik farklar.

BACKGROUNDS AND AIMS: Geographical differences between cases of colonic obstructions affect clinical course and outcome of patients. We aimed to establish regional clinical differences between patients with colonic obstruction from eastern and western regions of Turkey. METHODS: We retrospectively analysed 224 patients with colonic obstruction who were surgically treated in two hospital situated in Istanbul from western and in Van from eastern regions of Turkey. This analysis was made in respect of demographic features, causes of obstruction and location in the colon, complicated obstructions, postoperative clinical course and mortality. RESULTS: Men constituted 71.4% of patients with a mean age of 55.5 years. Obstruction site was the left colon in 82.5% and the sigmoid in 66% of patients from western region, and 91.7% (p = 0.03), and 85% (p = 0.007) respectively of those from eastern region. The leading causes of obstruction were obstructive cancer (52.5%) in Istanbul and volvulus (80.2%) Van respectively (p < 0.001). The colonic obstruction was complicated in 22% of patients. The rate of complicated obstruction was 17.5% and 26.4% (p = 0.07) in Van respectively. The overall postoperative mortality was found as 12.9%. The mortality being 8.6% in simple obstruction raised to 28% (p = 0.008) in complicated patients. CONCLUSIONS: We found significant differences in colonic obstruction cases between eastern and western parts of Turkey. The incidence of complicated obstruction is bigger in eastern region. A considerable mortality arises in surgically treated patients with colonic obstruction. Postoperative mortality was significantly elevated in cases of obstruction complicated by strangulation, necrosis, and perforation.