The relation of mutant p53 accumulation in transitional cell carcinoma of bladder with pathological stage, grade, recurrence and survival.

In this study prognostic significance and clinical value of mutant p53 gene in bladder transitional cell tumors is investigated. In our clinic, between 1997-2000, transurethral resection was performed in 48 cases, 3 females (6%) and 45 males (94%) with the diagnosis of primary bladder tumor, age ranges between 30-81 years old (average 58.9 +/- 9.9). The patients whose pathology results were transitional cell carcinoma were gathered into two groups as p53 positive and p53 negative by immunohistochemical study. These cases who were followed 1-36 months were compared to each other for pathologic state, tumor grade, recurrence and survival. It's found out that mutant p53 accumulation is related to high grade and pathologic stage tumors. But it's concluded that p53 positivity doesn't effect recurrence and survival rates.

Comparision of intracorporeal lithotripsy methods and forceps use for distal ureteral stones: seven years experience.

OBJECTIVES: To evaluate and to compare the safety and efficacy of ureteroscopic lithotripsy methods and forceps use for distal ureteral stones. MATERIALS AND METHODS: 514 patients were evaluated retrospectively who were treated by dye laser, electrohydraulic or ultrasonic lithotripsy or direct forceps extraction for distal ureteral stones between May 1992-October 1999. RESULTS: Laser lithotripsy was determined to be the most effective method with 86.9% success, while ultrasonic lithotripsy was the least effective method with 77.3% success rate. For smaller stones forceps extraction had a 88.5% success rate. CONCLUSION: Ureteroscopic lithotripsy methods are all alternative choice of treatment methods in distal ureteral stones. To our experience, laser lithotripsy is the most effective method of all intracorporeal lithotripsy methods as far as the success and complication rates are concerned.