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Nutrients ; 11(4)2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30939748

RESUMO

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndromein the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (ß = 0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (ß = 0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.


Assuntos
Doenças Cardiovasculares/sangue , Creatinina/sangue , Sono/fisiologia , Ácido Úrico/sangue , Idoso , Biomarcadores/sangue , Estudos Transversais , Feminino , Humanos , Masculino , Região do Mediterrâneo , Pessoa de Meia-Idade , Fatores de Risco , Espanha
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