[Endoprosthetic repair of the abdominal aorta in patients with infrarenal aneurysm and unfavourable anatomy of its proximal neck].

Analysed herein are immediate and remote results of endoprosthetic repair of the abdominal aorta in patients with unfavourable anatomy of its proximal neck. Group I (Study Group) was composed of 31 patients with unfavourable anatomy of the proximal neck, the control group (Group II) comprised a total of 52 patients with no unfavourable anatomical factors. The criteria of assessment were as follows: technical success, adequate position of the endograft, frequency of the development of various endoleaks, duration of the operation and hospital stay, lethality in the remote period, and necessity of secondary interventions. Technical success of endoprosthetic repair was achieved in 100% of patients in the both groups. An adequate position by the proximal end of the coated portion of the endograft was observed in 27 (87.1%) patients of Group I and in 51 (98.1%) patients of the control group (p=0.08). Secondary postdilatation of the endograft's body in the proximal neck was statistically more often performed in the study group of patients. The duration of the operation and hospital stay in the compared groups had no statistically significant differences. In the remote period, patients with unfavourable morphology of the proximal neck were found to develop type I-A endoleaks into the cavity of the aneurysm. By other evaluated criteria such as the total survival rate, secondary interventions, graft migration, type I-B, II and V endoleaks no statistically significant differences were revealed. It was concluded that endoprosthetic repair of the abdominal aorta in patients with unfavourable anatomy of the proximal neck of the aneurysm is associated with admissible immediate, short- and long-term outcomes. Longer follow up is required in order to more adequately asses the reliability of the obtained findings.

[Twelve months results of percutaneous coronary interventions in patients with ischemic heart disease combined with diabetes mellitus using sirolimus and everolimus covered stents].

We included into this study 112 patients with ischemic heart disease (IHD) and concomitant type 2 diabetes mellitus (DM) subjected to percutaneous coronary interventions with stenting. Everolimus and sirolimus eluting stents (EES and SES) were implanted in 54 (group 1) and 58 (group 2) patients, respectively. After 12 months in groups 1 and 2 rates of repeat target lesion revascularizations (TLR) were 5.5 and 8.6% (odds ratio - OR - 0.62, 95% confidence interval - CI - 0.14- 2.74, p = 0.72); acute myocardial infarctions (MI) - 3.7 and 5.2% (OR 0.71, 95% CI 0.11- 4.4, p = 0.94); deaths - 1.85 and 1.7% (OR 1.1, 95% CI 0.1- 17.6, p = 1.0), respectively. There was no significant difference between groups by rate of unfavorable cardiac events (composite of cardiac death, nonfatal MI, and clinically indicated TLR) - 11.1 and 15.5% in groups 1 and 2, respectively (OR 0.68, 95% CI 0.225- 2.059, p = 0.69). Rates of stent thrombosis also did not differ (1.85 and 3.4% in groups 1 and 2, respectively; OR 0.53, 95% CI 0.05- 6.0; p = 0.94). Thus the use of EES and SES in patients with IHD and type-2 DM was equally effective.

[The thoracic aorta aneurism stenting].

27 patients with thoracic aortic aneurism with dissection type III were operated on and stented. The mean age was 56±11,17 years. Men were 24, women 3. 1 patient developed intraoperative stent-graft leakage type IV, and 1 - type II. Both cases needed no additional manipulations. Minimal invasiveness of the procedure and pain absence allowed early activisation of patients. 2 patients had postoperative paraplegia, which was successfully treated by spinal drainage. There were no lethal cases. The long-term follow-up showed no leakage on CT scans; 11 patients demonstrated complete closure of false canal of the stented segment. The overall survival rate was 92.6% after 60 months of follow-up. Unfavorable results were registered in 29.6%.

[Coronary stenting in patients with ischemic heart disease with multivessel involvement of coronary vascular bed and low Syntax score].

MATERIAL AND METHODS: We followed 619 patients with ischemic heart disease (IHD) and multivessel involvement of coronary arteries: 317 patients subjected to coronary artery bypass grafting (CABG, group 1) and 302 patients subjected to multivessel percutaneous coronary intervention (PCI, group 2) with implantation of drug eluting stents. Both groups had comparable clinical characteristics. During hospitalization we registered deaths and unfavorable cardiological and cerebrovascular events. In remote period after revascularization we assessed survival, angina recurrences and related repeat revascularizations, and rate of severe cardiovascular complications (composite of deaths, acute myocardial infarctions [AMI], stroke, and repeat myocardial revascularizations). RESULTS: During hospitalization there were no significant differences between groups by parameters studied: death rate was 1.7 and 0.9%, that of AMI 2.6 and 1.9%, of stroke 0.9% and 0, of composite of death, AMI, and stroke 5.1 and 1.9% (p = 0.37) in groups 1 and 2, respectively. Survival in remote period was 90.2 (group 1) and 92.7% (group 2). Comparison of Kaplan-Meier survival curves also revealed no significant differences between groups. Angina recurrence/repeat revascularization took place in 54 (17.0%) and in 64 (21.2%) patients in groups 1 and 2, respectively (p = 0.128). Repeat revascularization was carried out in 32 of 54 patients (59.3%) in group 1 and in 58 Of 64 patients (90.6%) in group 2. Rate of severe unfavorable events during whole period of follow up was 33.1% in group 1 and 30.5% in group 2 (p > 0.05). CONCLUSION: In IHD patients with multivessel coronary artery involvement and low Syntax Score immediate and long term (5 year) results of stenting with drug eluting stents are not inferior to results of CABG.

[Results of point stenting of extended coronary stenoses in patients with ischemic heart disease]. / Rezul'taty "tochechnogo" stentirovaniia protiazhennykh stenozov koronarnykh arterii u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The paper analyzes the immediate and long-term results of point stenting in patients with extended (more than 30 mm) coronary stenoses and compares them with those obtained by routine stenting. The study included 177 patients with varying extent stenoses who underwent traditional implantation of intracoronary stents. Thirty-seven patients undergone the so-called point stenting formed a separate group. There was no significant difference in clinical and angiographic success rates between the patients of all three groups. Significant difference was also absent in subacute stent thrombosis between the patients of Groups 2 and 3 and those of the point stenting group. Thus, acute or subacute stent thrombosis was noted in 4 (2.3%) patients from the routine stenting groups, all the patients being from Groups 2 and 3, and in 2 (5.4%) from the point stenting group. No significant difference was found in the incidence of recurrent angina pectoris (restenosis) between Groups 1 and 2 and between Groups 2 and 3. At the same time, recurrent angina (restenosis) significantly more frequently developed in the patients of Group 3 than those of Group 1. As compared with Groups 2 and 3 patients, there was no significant difference in the incidence of recurrent angina (restenosis).

[Immediate and long-term results of coronary stent implantation without predilatation (direct stenting) in patients with coronary heart disease]. / Neposredstvennye i otdalennye rezul'taty implantatsii koronarnykh stentov bez vypolneniia predilatatsii ("priamoe" stentirovanie) u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The paper assesses the immediate and long-term results of direct stenting (without the stage of predilation) and compares with the outcomes of conventional stent implantation. A prospective study included 183 patients. All the patients were divided into two groups according to the procedure of stent implantation. In 85 (46.7%) patients, the stent was implanted without preliminary predilation of stenosis (direct stenting). These patients formed Group 1. Group 2 comprised 97 (53.3%) patients in whom the stent was placed by using the routine procedure. All the patients enrolled into the study had types A, B1, and B2 stenoses according to the ACC/AHA classification and received the conventional antiaggregatory and anticoagulant therapy. The technical success of direct stenting was 97.7%. There were no cases of stent dislocation and loss during direct stenting or expansion of a balloon and stent. Analyzing the immediate results in all the patients of the both groups showed a positive angiographic success. Thus, a primary angiographic and clinical success of direct stenting was achieved in all (100%) patients. Recurrent angina pectoris with restenosis was observed in 8 (9.4%) patients in Group 1 and in 21 (21.6%) in Group 2 (p < 0.05). Direct stenting significantly differs from the routine stent implantation in all procedure parameters. Thus, direct stenting in patients with uncomplicated stenoses is a safe and feasible procedure.

[Comparison of the results of stenting ans balloon angioplasty of coronary arteries in relation to the type of stenosis]. / Sravnenie rezul'tatov stentirovaniia i ballonnoi angioplastiki koronarnykh arterii v zavisimosti ot tipa stenoza.

Based on the comparison of the immediate and late results of stenting and balloon angioplasty (BA), the authors consider whether it is expedient to perform stenting of coronary arteries (CA) in all cases of BA in patients with coronary heart disease (CHD) and different types of CA stenosis. The study included 410 patients: a group of stenting (n = 197) and a group of traditional BA (n = 213). All the patients in both groups were divided into four subgroups in relation to the type of detected stenosis according to the classification of the American Association of Cardiologists (ACC/AHA). The positive angiographic and clinical results were observed in all 197 patients after stenting. This was associated neither with the type of dilated stenosis nor with the design of an implanted stent. In dilation of types A and B1 stenoses, a stent-like result was significantly more frequently observed than in dilation of types B2 and C stenoses. There was no significant difference in the development of restenosis in patients after routine BA and stenting of types A and B1 stenoses. At the same time, after BA of types B2 and C stenoses, restenosis developed significantly more frequently than in stenting. Thus, on the basis of this study, it may be stated that the traditional BA yields the so-called stent-like result significantly more frequently in patients with uncomplicated forms of CA stenoses than in those with complicated ones. Once the stent-like result is achieved in patients with type A stenoses, stenting should not be performed since the latter fails to improve the immediate and late results of angioplasty. Despite that the stent-like result is achieved in patients with complicated forms of CA stenoses, it is expedient to make stenting. Our findings indicate that the obtained good immediate result reduces the incidence of restenosis.

[Indications to balloon angioplasty and intracoronary stenting in patients with ischemic heart disease]. / Pokazaniia k ballonnoi koronoranoi angioplastike i intrakoronarnomu stentirovaniiu u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Four hundred and ten patients with ischemic heart disease (IHD) were treated. The study group consisted of 197 patients with IHD who have undergone intracoronary stenting (IS). The control group consisted of 213 patients treated with traditional balloon coronary angioplasty (BCA). All the patients in both groups were divided in four subgroups depending on a type of stenosis by classification ACC/AHA. A positive angiographic and clinical result straight away after IS was seen in all 197 patients. Any links with a stenosis type or with construction of the stent were not revealed. In 5 (2.5%) patients on day 5-7 after IS acute coronary occlusion in the place of stenting was seen. In 2 (1%) patients attempt of recanalization was unsuccessful, in both cases transmural myocardial infarction has developed. Thus, in further study 195 (98.98%) patients were included. Out of 213 patients after traditional BCA immediate good angiographic and clinical results were achieved in 191 (89.7%). There were no differences in rate of good immediate results of IS and BCA of types A and B1 stenoses. In types B2 and C stenosis immediate good results were achieved more often in group with IS. Good immediate results after BCA were better in patients with type A stenosis than with B2 and C stenoses. Rate of the "stent-like" result after BCA of types A and B1 stenosis was higher than after dilatation of types B2 and C stenosis. There was no difference in rate of restenosis after traditional BCA and IS of types A and B1 stenosis. In BCA of types B2 and C stenosis restenosis was seen more often than in IS. It is concluded that in patients with types A and B1 stenoses "stent-like" result is achieved more often after traditional BCA than in patients with types B2 and C stenosis. In patients with type A stenosis and "stent-like" result stenting does not improve significantly long-term results. In patients with types B2 and C stenosis and "stent-like" result IS is tustified. Good immediate results of angioplasty in these patients don't reduce the rate of restenosis, white IS does reduce its rate.

[Results of coronary stenting in relation to the length of an implanted stent]. / Rezul'taty stentirovaniia koronarnykh arterii v zavisimosti ot dliny implantirovannogo stenta.

The paper considers the impact of the length of an implanted stent on the early and late outcomes of intracoronary stenting. The study included 177 patients on a retrospective basis. They all underwent intracoronary stenting of 215 stenoses. All the patients were divided into three groups in relation to the length of an implanted segment (under 20 mm, 20-30 mm, and under 30 mm). In 16 (9.04%) of the 177 patients, for complete stenosis correction, several, but not one, stents were inserted, i.e. multiple stenting of a coronary stenting was performed. The stents were implanted by the conventional procedure. There was no significant difference in clinical and angiographic success rates between the patients of all three groups. There were no complications, such as transmural myocardial infarction and deaths in any groups. Acute stent thrombosis was noted only in 1 (1.8%). There was no significant difference in the incidence of subacute stent thrombosis between Groups 2 and 3 patients. No case of subacute thrombosis of implanted stents was noted in Group 1 patients. Thus, acute and subacute stent thromboses were observed in 4 (2.3%) patients, they being all from Groups 2 and 3. There was no significant difference in the development of restenosis between Groups 1 and 2 and Groups 2 and 3. At the same time, restenosis significantly more frequently developed in patients from Group 3 than in those from Group 1. Thus, the findings indicate that the length of a stented segment is an important factor that influence both early and late outcomes of intracoronary stenting.

[Immediate and long-term outcomes of coronary stenting in relation to stent implantation pressure in patients with coronary heart disease]. / Neposredstvennye i otdalennye rezul'taty koronarnogo stentirovaniia v zavisimosti ot davleniia implantatsii stentov u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The paper evaluates the pressure impact of implantation of intracoronary stents of different designs on the immediate and long-term outcomes of stenting. A retrospective study included 192 patients. Matrix and wire stents were implanted in 97 (50.5%) and 95 (49.5%) patients, respectively. In one part of the patients, the coronary stent was implanted under nominal pressure, in the other, the stent after implantation was extended with a balloon by using high pressure. Good immediate angiographic and clinical results were obtained in all 192 patients. Thirty three (17.2%) patients were found to have coronary spasm at the site of a stent. There was no significant difference in the development of coronary spasm, which was associated with the type of an implanted (matrix or wire) stent and with the pattern of its implantation (under high or nominal pressure). Dissection along the stent edges developed in 17 of the 192 patients, which amounted to 8.8%. It significantly more frequently developed in patients from Subgroup IA than in those from Subgroup IB. There was no significant difference in the development of restenosis in patients after implantation of matrix or wire stents and in the relation to the stent implantation pressure.

[Results of point stenting of extended coronary stenosis in patients with ischemic heart disease]. / Rezul'taty "tochechnogo" stentirovaniia protiazhennykh stenozov koronarnykh arterii u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The paper analyzes the immediate and long-term results of point stenting in patients with extended (more than 30 mm) coronary stenoses and compares them with those obtained by routine stenting. The study included 177 patients with varying extent stenoses who underwent traditional implantation of intracoronary stents. Thirty-seven patients undergone the so-called point stenting formed a separate group. There was no significant difference in clinical and angiographic success rates between the patients of all three groups. Significant difference was also absent in subacute stent thrombosis between the patients of Groups 2 and 3 and those of the point stenting group. Thus, acute or subacute stent thrombosis was noted in 4 (2.3%) patients from the routine stenting groups, all the patients being from Groups 2 and 3, and in 2 (5.4%) from the point stenting group. No significant difference was found in the incidence of recurrent angina pectoris (restenosis) between Groups 1 and 2 and between Groups 2 and 3. At the same time, recurrent angina (restenosis) significantly more frequently developed in the patients of Group 3 than those of Group 1. As compared with Groups 2 and 3 patients, there was no significant difference in the incidence of recurrent angina (restenosis).

[Chronic occlusions in patients with coronary heart disease: results of recanalization]. / Rezul'taty rekanalizatsii khronicheskikh okkliuzii u bol'nykh IBS.

The paper analyzes the results of endovascular treatment in 298 patients with chronic occlusions or subtotal stenoses of coronary arteries. The authors show that balloon coronary angioplasty for chronic coronary occlusions is an effective and relatively safe techniques of myocardial revascularization. Successful endovascularization has been achieved in 68.1% of patients with chronic coronary occlusions and in 97.5% of those with subtotal coronary stenoses. The results show a high incidence of restenosis and asymptomatic reocclusion.

[A comparative analysis of the immediate and late results of coronary balloon angioplasty in bifurcation stenoses performed by the traditional method and by the "2-guide" method]. / Sravnitel'nyi analiz blizhaishikh i otdalennykh rezul'tatov ballonnoi korornarnoi angioplastiki bifurkatsionnykh stenozov, provodimoi traditsionnym metodom i metodom "dvukh provodnikov".

To evaluate the efficiency of balloon coronary angioplasty (BCA) for bifurcation stenoses, which had been made by the two-guide method, the results of the angioplasties were examined in 147 patients with coronary heart disease. BCA had been performed routinely in 54 patients and by the two-guide method in 32. Sixty-one patients undergone angioplasty for nonbifurcation lesions served as a control group. In the group of routine BCA procedure, poor results with residual stenosis of the major vessel were seen in 13% of cases, the incidence of complication (dissection of unfavourable types, thrombosis of the major vessel) was 29.6%. In the two-guide BCA, these indices were 15.6 and 2%, respectively, the incidence of restenosis was 46.9% and that of branch lesions was 6.3%. The findings have led to the following conclusions that routine angioplasty of bifurcation stenoses yields poor early and late results of dilatation of lateral branches. The use of the two-guide method substantially reduces the risk of damage to a lateral branch, improves immediate dilatation of the major vessel, yet fails to affect the number of restenosis in the late period.

[Outcomes of balloon coronary angioplasty of bifurcation stenoses in patients with ischemic heart disease]. / Rezul'taty ballonnoi koronarnoi angioplastiki bifurkatsionnykh stenozov u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The study included 322 patients with bifurcation lesion of the coronary bed who had angioplasty by the conventional procedure by employing one balloon. The authors analyze whether there is a correlation of balloon coronary angiographic findings with the following X-ray morphological characteristics: the origin of a lateral branch from the stenotic segment of the coronary artery, that of the branch at a distance of no more than 10 mm proximal or distal to stenosis, the angle of branch origin. Based on the findings, it was concluded that the origin of the branch from the stenotic segment is a factor that limits an angiographic success of dilatation of the great coronary vessel. The origin of the branch 10 mm proximal or distal to stenosis does not affect the angiographic success of the procedure. The risk factors of lateral branch lesion include the origin of the branch from a stenotic segment, an angle of branch origin of over 45 degrees.