The effects of estimation accuracy, estimation approach, and number of selected channels using formant-priority channel selection for an "n-of-m" sound processing strategy for cochlear implants.

Previously, selection of l channels was prioritized according to formant frequency locations in an l-of-n-of-m-based signal processing strategy to provide important voicing information independent of listening environments for cochlear implant (CI) users. In this study, ideal, or ground truth, formants were incorporated into the selection stage to determine the effect of accuracy on (1) subjective speech intelligibility, (2) objective channel selection patterns, and (3) objective stimulation patterns (current). An average +11% improvement (p < 0.05) was observed across six CI users in quiet, but not for noise or reverberation conditions. Analogous increases in channel selection and current for the upper range of F1 and a decrease across mid-frequencies with higher corresponding current, were both observed at the expense of noise-dominant channels. Objective channel selection patterns were analyzed a second time to determine the effects of estimation approach and number of selected channels (n). A significant effect of estimation approach was only observed in the noise and reverberation condition with minor differences in channel selection and significantly decreased stimulated current. Results suggest that estimation method, accuracy, and number of channels in the proposed strategy using ideal formants may improve intelligibility when corresponding stimulated current of formant channels are not masked by noise-dominant channels.

The effects of Lombard perturbation on speech intelligibility in noise for normal hearing and cochlear implant listeners.

Natural compensation of speech production in challenging listening environments is referred to as the Lombard effect (LE). The resulting acoustic differences between neutral and Lombard speech have been shown to provide intelligibility benefits for normal hearing (NH) and cochlear implant (CI) listeners alike. Motivated by this outcome, three LE perturbation approaches consisting of pitch, duration, formant, intensity, and spectral contour modifications were designed specifically for CI listeners to combat speech-in-noise performance deficits. Experiment 1 analyzed the effects of loudness, quality, and distortion of approaches on speech intelligibility with and without formant-shifting. Significant improvements of +9.4% were observed in CI listeners without the formant-shifting approach at +5 dB signal-to-noise ratio (SNR) large-crowd-noise (LCN) when loudness was controlled, however, performance was found to be significantly lower for NH listeners. Experiment 2 evaluated the non-formant-shifting approach with additional spectral contour and high pass filtering to reduce spectral smearing and decrease distortion observed in Experiment 1. This resulted in significant intelligibility benefits of +30.2% for NH and +21.2% for CI listeners at 0 and +5 dB SNR LCN, respectively. These results suggest that LE perturbation may be useful as front-end speech modification approaches to improve intelligibility for CI users in noise.

A speech perturbation strategy based on "Lombard effect" for enhanced intelligibility for cochlear implant listeners.

The goal of this study is to determine potential intelligibility benefits from Lombard speech for cochlear implant (CI) listeners in speech-in-noise conditions. "Lombard effect" (LE) is the natural response of adjusting speech production via auditory feedback due to noise exposure within acoustic environments. To evaluate intelligibility performance of natural and artificially induced Lombard speech, a corpus was generated to create natural LE from large crowd noise (LCN) exposure at 70, 80, and 90 dB sound pressure level (SPL). Clean speech was mixed with 15 and 10 dB SNR LCN and presented to five CI users. First, speech intelligibility was analyzed as a function of increasing LE and decreasing SNR. Results indicate significant improvements (p < 0.05) with Lombard speech intelligibility in noise conditions for 80 and 90 dB SPL. Next, an offline perturbation strategy was formulated to modify/perturb neutral speech so as to mimic LE through amplification of highly intelligible segments, uniform time stretching, and spectral mismatch filtering. This process effectively introduces aspects of LE into the neutral speech, with the hypothesis that this would benefit intelligibility for CI users. Significant (p < 0.01) intelligibility improvements of 13% and 16% percentage points were observed for 15 and 10 dB SNR conditions respectively for CI users. The results indicate how LE and LE-inspired acoustic and frequency-based modifications can be leveraged within signal processing to improve intelligibility of speech for CI users.

CCi-MOBILE: Design and Evaluation of a Cochlear Implant and Hearing Aid Research Platform for Speech Scientists and Engineers.

Hearing loss is an increasingly prevalent condition resulting from damage to the inner ear which causes a reduction in speech intelligibility. The societal need for assistive hearing devices has increased exponentially over the past two decades; however, actual human performance with such devices has only seen modest gains relative to advancements in digital signal processing (DSP) technology. A major challenge with clinical hearing technologies is the limited ability to run complex signal processing algorithms requiring high computation power. The CCi-MOBILE platform, developed at UT-Dallas, provides the research community with an open-source, flexible, easy-to-use, software-mediated, powerful computing research interface to conduct a wide variety of listening experiments. The platform supports cochlear implants (CIs) and hearing aids (HAs) independently, as well as bimodal hearing (i.e., a CI in one ear and HA in the contralateral ear). The platform is ideally suited to address hearing research for: both quiet and naturalistic noisy conditions, sound localization, and lateralization. The platform uses commercially available smartphone/tablet devices as portable sound processors and can provide bilateral electric and acoustic stimulation. The hardware components, firmware, and software suite are presented to demonstrate safety to the speech scientist and CI/HA user, highlight user-specificity, and outline various applications of the platform for research.

Formant priority channel selection for an "n-of-m" sound processing strategy for cochlear implants.

The Advanced Combination Encoder (ACE) signal processing strategy is used in the majority of cochlear implant (CI) sound processors manufactured by Cochlear Corporation. This "n-of-m" strategy selects "n" out of "m" available frequency channels with the highest spectral energy in each stimulation cycle. It is hypothesized that at low signal-to-noise ratio (SNR) conditions, noise-dominant frequency channels are susceptible for selection, neglecting channels containing target speech cues. In order to improve speech segregation in noise, explicit encoding of formant frequency locations within the standard channel selection framework of ACE is suggested. Two strategies using the direct formant estimation algorithms are developed within this study, FACE (formant-ACE) and VFACE (voiced-activated-formant-ACE). Speech intelligibility from eight CI users is compared across 11 acoustic conditions, including mixtures of noise and reverberation at multiple SNRs. Significant intelligibility gains were observed with VFACE over ACE in 5 dB babble noise; however, results with FACE/VFACE in all other conditions were comparable to standard ACE. An increased selection of channels associated with the second formant frequency is observed for FACE and VFACE. Both proposed methods may serve as potential supplementary channel selection techniques for the ACE sound processing strategy for cochlear implants.

In vitro effects of dental cements on hard and soft tissues associated with dental implants.

STATEMENT OF PROBLEM: Dental cements for cement-retained restorations are often chosen based on clinician preference for the product's material properties, mixing process, delivery mechanism, or viscosity. The composition of dental cement may play a significant role in the proliferation or inhibition of different bacterial strains associated with peri-implant disease, and the effect of dental cements on host cellular proliferation may provide further insight into appropriate cement material selection. PURPOSE: The purpose of this in vitro study was to investigate the cellular host response of bone cells (osteoblasts) and soft tissue cells (gingival fibroblasts) to dental cements. MATERIAL AND METHODS: Zinc oxide (eugenol and noneugenol), zinc phosphate, and acrylic resin cements were molded into pellets and directly applied to confluent preosteoblast (cell line MC3T3 E1) or gingival fibroblast cell cultures (cell line HGF) to determine cellular viability after exposure. Controls were defined as confluent cell cultures with no cement exposure. Direct contact cell culture testing was conducted following International Organization for Standardization 10993 methods, and all experiments were performed in triplicate. To compare either the MC3T3 E1 cell line, or the HGF cell line alone, a 1-way ANOVA test with multiple comparisons was used (α=.05). To compare the MC3T3 E1 cell line results and the HGF cell line results, a 2-way ANOVA test with multiple comparisons was used (α=.05). RESULTS: The results of this study illustrated that while both bone and soft tissue cell lines were vulnerable to the dental cement test materials, the soft tissue cell line (human gingival fibroblasts) was more susceptible to reduced cellular viability after exposure. The HGF cell line was much more sensitive to cement exposure. Here, the acrylic resin, zinc oxide (eugenol), and zinc phosphate cements significantly reduced cellular viability after exposure with respect to HGF cells only. CONCLUSIONS: Within the limitation of this in vitro cellular study, the results indicated that cell response to various implant cements varied significantly, with osteoblast proliferation much less affected than gingival fibroblast cells. Furthermore, the zinc oxide noneugenol dental cement appeared to affect the cell lines significantly less than the other test cements.

A finite element analysis of novel vented dental abutment geometries for cement-retained crown restorations.

Recent literature indicates that the long-term success of dental implants is, in part, attributed to how dental crowns are attached to their associated implants. The commonly utilized method for crown attachment - cementation, has been criticized because of recent links between residual cement and peri-implant disease. Residual cement extrusion from crown-abutment margins post-crown seating is a growing concern. This study aimed at (1) identifying key abutment features, which would improve dental cement flow characteristics, and (2) understanding how these features would impact the mechanical stability of the abutment under functional loads. Computational fluid dynamic modeling was used to evaluate cement flow in novel abutment geometries. These models were then evaluated using 3D-printed surrogate models. Finite element analysis also provided an understanding of how the mechanical stability of these abutments was altered after key features were incorporated into the geometry. The findings demonstrated that the key features involved in improved venting of the abutment during crown seating were (1) addition of vents, (2) diameter of the vents, (3) location of the vents, (4) addition of a plastic screw insert, and (5) thickness of the abutment wall. This study culminated in a novel design for a vented abutment consisting of 8 vents located radially around the abutment neck-margin plus a plastic insert to guide the cement during seating and provide retrievability to the abutment system.Venting of the dental abutment has been shown to decrease the risk of undetected residual dental cement post-cement-retained crown seating. This article will utilize a finite element analysis approach toward optimizing dental abutment designs for improved dental cement venting. Features investigated include (1) addition of vents, (2) diameter of vents, (3) location of vents, (4) addition of plastic screw insert, and (5) thickness of abutment wall.