[Optimization of treatment of elderly patientswith diabetic foot syndrome and mediakaltsinozom arteries].

The objective of the research was to study the effectiveness of the drug Cytoflavin in the comprehensive treatment of mixed form diabetic foot syndrome with media calcification arteries in 75 elderly patients with type 2 diabetes. Depending on the regimen, patients were divided into two groups: control received basic therapy; main group in addition to the base, received the drug Cytoflavin 10 ml 0,9 % NaCl 200 ml for 10 days, followed by a transition to the tablet form of the drug - 2 tablets 2 times per day orally for one month. The inclusion of the drug Cytoflavin in the treatment regimen increased the effectiveness of treatment, which was shown to improve tissue oxygenation due to the normalization of the basal oxygen tension, restoring the activity of antioxidant enzymes and, consequently, in an authentic decrease in the average time of hospital treatment and a decrease in the number of repeated surgical interventions and reamputatsy over the next year.

[Rationale of application of the drug Cytoflavin in complex treatment of patients with diabetic foot syndrome with mediacalcification arteries].

The study involved 60 patients with diabetic foot syndrome (DFS) with severe subcompensated diabetes type II. All patients were available mediacalcification foot and lower leg arteries of different severity. Depending on the treatment, all patients were divided into 2 groups by stratified randomization. The first group received basic therapy that is indicated for DFS which included antibiotics, vessels extending drugs neuroprotective and detoxification facilities. The second group of patients in addition to basic therapy received the drug cytoflavin 10 ml 0.9% NaCl 200 ml for 10 days, followed by transfer to the tablet form cytoflavin 2 tablets 2 times a day orally for 1 month. We noted a positive trend treat patients in addition to standard therapy received the drug cytoflavin, resulting in a marked neuroprotective, antihypoxant and antioxidant effects of the drug. Thus, the use of complex surgical treatment of patients with mixed form DFS cytoflavin reduces the severity of distal polyneuropathy, improves tissue oxygenation and restores the activity of antioxidant enzymes system, manifested a marked neuroprotective, anti-hypoxic and antioxidant effects of drugs and indications to justify its use in this condition.

[The efficacy of vobenzym ++ in the treatment of intravascular disseminated blood coagulation syndrome in diabetic angiopathy of lower extremities]. / Efektyvnist' vobenzymu v likuvanni syndromu dyceminovanoho vnutrishn'osudynnoho zcidannia kovi pry diabetychnii anhiopatiï nyzhnikh kintsivok.

In 20 patients with diabetic angiopathy of lower extremities and purulent-necrotic complications, in whom the diagnosis of chronic syndrome of disseminated intravascular blood coagulation (DIC-syndrome), preparation vobenzym (Mucos Pharma & Co, Germany) was applied. High efficacy of the preparation was noted: more rapid healing of purulent-necrotic wounds, elimination of symptoms, stabilization of the hemodynamics indexes.