Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer.

Recently, an intense attention has been paid to the application of natural compounds as a novel therapeutic strategy for cancer treatment. Quercetin, a natural flavonol present in many commonly consumed food items, is widely demonstrated to exert inhibitory effects on cancer progression through various mechanisms. Since there is a strong association with diets containing abundant vegetables, fruits, and grains, and significant decline in the risk of colon cancer, accumulation studies have focused on the anticancer potential of quercetin in colorectal cancer. Cell cycle arrest, increase in apoptosis, antioxidant replication, modulation of estrogen receptors, regulation of signaling pathways, inhibition of and metastasis and angiogenesis are among various mechanisms underlying the chemo-preventive effects of quercetin in colorectal cancer. This review covers various therapeutic interactions of Quercetin as to how targets cellular involved in cancer treatment.

MRI findings of prostate stromal tumour of uncertain malignant potential: a case report.

Prostatic stromal tumours are rare neoplasias that include benign, malignant and borderline lesions. Stromal tumour of uncertain malignant potential (STUMP) has been recently described and only a few reports exist in the literature. As a rare and distinct neoplasia, to date, there is no description of MRI findings of prostate STUMP. In this article, we describe the clinical and MRI features with histopathological correlation of a patient with prostate STUMP.

Stray light correction for diode-array-based spectrometers using a monochromator.

Photodiode-array-based spectrometers are increasingly being used in a wide variety of applications. However, the signal measured by this type of instrument often is not what is anticipated by the user and is often subject to contamination from stray light. This paper describes an efficient and low-cost stray light correction approach based on a relatively simple system using a monochromator-based source. The paper further discusses the limitations of using a monochromator instead of a laser, as used by previous researchers, and its impact on the quality of the stray light correction. The reliability and robustness of the stray light correction matrix generated have been studied and are also reported.

Temperature and nonlinearity corrections for a photodiode array spectrometer used in the field.

Temperature and nonlinearity effects are two important factors that limit the use of photodiode array spectrometers. Usually the spectrometer is calibrated at a known temperature against a reference source of a particular spectral radiance, and then it is used at different temperatures to measure sources of different spectral radiances. These factors are expected to be problematic for nontemperature-stabilized instruments used for in-the-field experiments, where the radiant power of the site changes continuously with the sun tilt. This paper describes the effect of ambient temperature on a nontemperature-stabilized linear photodiode array spectrometer over the temperature range from 5 °C to 40 °C. The nonlinearity effects on both signal amplification and different levels of radiant power have also been studied and are presented in this paper.

Influence of epithelial-mesenchymal interaction on the viability of facial mesenchyme in vitro.

Separation and recombination experiments, employing a variety of tissue configurations in organ culture, were performed to determine the extent to which the epithelium of the maxillary process influences the viability of the underlying mesenchyme during organogenesis. The results of these studies indicated that the viability of mesenchyme of the maxillary process of early stage embryos was severely impaired when separated from the overlying epithelium. The influence of epithelium on the viability of mesenchyme was stage dependent; that is, the requirement for the presence of epithelium for the maintenance of the viability of mesenchyme became progressively less pronounced at older developmental stages. The response of mesenchyme to the presence of recombined epithelium resulted in the appearance of a delimited zone of influence extending, within specific boundaries, from the epithelial-mesenchymal interface. Preliminary data from homotypic (maxillary epithelium-maxillary mesenchyme), heterotypic (limb apical ectodermal ridge-maxillary mesenchyme) and heterochronic (stage 28 epithelium-stage 22 mesenchyme) recombination experiments indicated that viability of mesenchyme could be achieved only through direct epithelial-mesenchymal contact which allowed restoration of normal morphological relationships at the interface of the two tissues.