[The association of megaesophagus, Binder's syndrome and dysautonomia: a new neurocristopathy]. / Association méga-oesophage, syndrome de Binder et dysautonomie: une nouvelle neurocristopathie?

A case of esophageal achalasia is reported in a 12 year-old child. Nasal hypoplasia (Binder syndrome) and dysautonomia were associated. This may be explained by the common embryologic origin (neural crests) of nasal bud, autonomic nervous system and digestive intramural neurons. Such a neurocristopathy suggests exploration of the autonomic nervous system in cases of esophageal achalasia.

[Comparative hepatic toxicity of perhexiline maleate and griseofulvin in mice]. / Toxicité hépatique comparée du maléate de perhexiline et de la griséofulvine chez la souris.

Hepatic toxicity was observed in mice which had received Griseofulvin or Perhexilin Maleate over a period of several months. Treatment of griseofulvin alone gave rise to hepatitis with the presence of Mallory bodies (MB) whereas the same length of treatment with Perhexilin Maleate was associated with steatonecrosis with an absence of MB. When treatment was followed by a one month rest period hepatic lesions disappeared with no trace of sequelae. Cross-treatment studies showed that one week of Perhexiline Maleate was sufficient to induce MB in mice pretreated with Griseofulvin. Similarly, Griseofulvin administered to mice pretreated with Perhexilin Maleate gave rise to MB formation after one week as opposed to the usual two months incubation time (DENK et al.). The histological nature and mode of formation of these MB was identical to that encountered in acute alcoholic hepatitis. On addition, combined drug therapy employing Perhexilin Maleate suggests a particular hepatic toxicity in man in cases where the liver has become predisposed due to other therapeutic.

[Ultrastructural heterogeneity and assumed mode of formation of Mallory bodies in acute alcoholic hepatitis and in experimental hepatitis]. / Hétérogénéité ultrastructurale et mode de formation supposé des corps de Mallory dans l'hépatite alcoolique aiguë et les hépatites expérimentales.

Mallory bodies (MB) are characteristic features of human and experimental hepatitis they exhibit, by electron microscope, an heterogeneous structure. We propose a mode of formation of such MB, which would take place un a progressive way from simple form (bundles of microfilaments) to complex form (typical MB).