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1.
Case Rep Infect Dis ; 2018: 4910292, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30271644

RESUMO

Necrotizing fasciitis (NF) is a soft tissue infection affecting subcutaneous tissue and the muscular fascia without involvement of the muscle and can be either monomicrobial or polymicrobial. Monomicrobial infections are usually caused by group A streptococci, while infections caused by anaerobic germs usually affect immunodepressed patients. We report a rare case of NF caused by two anaerobic bacteria in an immunocompetent patient.

2.
Acta Diabetol ; 47(4): 341-4, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20563608

RESUMO

Epidemiology data predict that by the year 2025, diabetes will affect about 380 million people worldwide with a significant increase in patients with chronic renal disease progressing to hemodialysis. Diabetes-related peripheral vascular disease is a major risk factor for vascular access failure in patients on extracorporeal hemodialysis. Although peritoneal dialysis is a valid option for diabetics, peritonitis is still a main complication for these patients. We report the case of a 71-year-old type 2 diabetes patient treated by subcutaneous insulin, undergoing automated peritoneal dialysis (APD) who developed peritonitis and bloodstream infection by Ochrobactrum anthropi (O. anthropi). The patient was initially shifted to continuous ambulatory peritoneal dialysis (CAPD) and treated with intraperitoneal cefotaxime and gentamicin. According to antibiogram, cefotaxime was discontinued but lasting gentamicin. Within 48 h from admission, clear peritoneal effluent was observed with reduction in white blood cells count from 580/mm³ 77.9% neutrophils to less than 10/mm³. Prompt regression of infection without catheter removal and no relapse after over 7-month follow-up allowed supposing that O. anthropi did not colonized peritoneal catheter. O. anthropi is an emerging cause of nosocomial infection in immunocompromised patients. Cases of such infection in patients undergoing CAPD and hemodialysis have been already described. However, this is the first reported case of O. anthropi in a patient undergoing APD.


Assuntos
Diabetes Mellitus Tipo 2/complicações , Nefropatias Diabéticas/terapia , Infecções por Bactérias Gram-Negativas/complicações , Falência Renal Crônica/terapia , Ochrobactrum anthropi , Diálise Peritoneal Ambulatorial Contínua/efeitos adversos , Peritonite/etiologia , Idoso , Automação , Cateteres de Demora/efeitos adversos , Infecção Hospitalar/complicações , Infecção Hospitalar/etiologia , Nefropatias Diabéticas/complicações , Nefropatias Diabéticas/etiologia , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/etiologia , Masculino , Ochrobactrum anthropi/fisiologia , Diálise Peritoneal Ambulatorial Contínua/instrumentação
3.
New Microbiol ; 32(2): 199-204, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19579700

RESUMO

Vulvovaginal candidiasis is a common mucosal infection caused by saprophytic and opportunistic yeasts belonging to the Candida genus. 518 vaginal swabs, with positive fungal culture were collected from unselected women attending the Sexually Transmitted Disease clinic of an Italian tertiary care hospital over a six year period to determine the pathogen prevalence in vulvovaginal candidiasis and to evaluate in vitro the antifungal susceptibilities of yeast recovered by Sensititre YeastOne antifungal panel plates according to CLSI document M27-A2. The isolates belonging to the genus Candida were 495 (95.5%) with Candida albicans percentage equal to 61.2%. Voriconazole was highly active (MIC50 0.008; MIC90 0.5 microg/ml), regardless of the species tested. On the contrary, fluconazole susceptibility was based upon the species. The intrinsic resistance to fluconazole of C. krusei was confirmed.


Assuntos
Antifúngicos/farmacologia , Candida/efeitos dos fármacos , Candidíase Vulvovaginal/epidemiologia , Candidíase Vulvovaginal/microbiologia , Ambulatório Hospitalar , Antifúngicos/uso terapêutico , Candida/isolamento & purificação , Candidíase Vulvovaginal/prevenção & controle , Farmacorresistência Fúngica , Feminino , Fluconazol/farmacologia , Fluconazol/uso terapêutico , Humanos , Itália/epidemiologia , Testes de Sensibilidade Microbiana , Prevalência , Pirimidinas/farmacologia , Pirimidinas/uso terapêutico , Recidiva , Triazóis/farmacologia , Triazóis/uso terapêutico , Vagina/microbiologia , Voriconazol
5.
New Microbiol ; 31(4): 543-8, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19123311

RESUMO

We studied dermatophyte infections in patients attending the Dermatology Outpatients Clinic of S. Matteo hospital Pavia, Italy, during the period 2004-2006. A total of 100 samples were collected from 95 patients; 97 dermatophytes and 3 keratinophylic fungi were isolated. Trichophyton rubrum was the most frequent dermatophyte isolated (42.3%), followed by Microsporum canis (31%), T. mentagrophytes (14.5%) and M. gypseum (9.2%). Less frequently isolated were Epidermophyton floccosum and T. violaceum. The most common dermatophyte infections included tinea corporis, tinea pedis, tinea unguium, tinea capitis and tinea cruris. Zoophilic dermatophytes were most commonly recovered from children and adolescents with tinea capitis and tinea corporis. Anthropophilic species were identified mostly in adults with tinea pedis, tinea cruris and onychomycosis.


Assuntos
Arthrodermataceae/fisiologia , Dermatomicoses/epidemiologia , Dermatomicoses/microbiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Arthrodermataceae/isolamento & purificação , Criança , Pré-Escolar , Feminino , Cabelo/microbiologia , Humanos , Lactente , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Unhas/microbiologia , Prevalência , Distribuição por Sexo , Pele/microbiologia , Tinha/epidemiologia , Tinha/microbiologia , Trichophyton/isolamento & purificação
6.
New Microbiol ; 30(3): 303-7, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17802915

RESUMO

Invasive candidiasis in neonates has become an increasing problem over the past decade in Neonatal Intensive Care Units (NICUs). From August 2005 to January 2006, six invasive candidiasis occurred in neonates in NICU of the S. Matteo hospital of Pavia. The study focused on the species involved and their in vitro antifungal susceptibility. Genotyping was conducted to determine clonal relatedness. A total of 22 yeasts were isolated from different biological samples of neonates during six months. The infants were infected with or colonized by Candida albicans and six patients developed C. albicans deep infections. The genotyping of the transposable intron region of C. albicans strains showed that they belonged to the genotype A (17 isolates) and genotype B (5 isolates). The RAPD confirmed these results. These data suggest that nosocomial transmission of C. albicans could be take into account as a mode of acquisition by neonates in NICUs at this hospital.


Assuntos
Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Candida albicans/genética , Candidíase/epidemiologia , Candidíase/microbiologia , Unidades de Terapia Intensiva Neonatal , Epidemiologia Molecular , Infecção Hospitalar/epidemiologia , Genes Fúngicos/genética , Humanos , Lactente , Recém-Nascido , Íntrons/genética , Itália/epidemiologia , Testes de Sensibilidade Microbiana , Especificidade da Espécie
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