Preventive health services received by minority women aged 45-64 and the goals of healthy people 2000.

We attempted to evaluate the preventive health services received by minority women aged 45-64 in an underserved region of Boston. We compared two surveys of disease burden and preventive health services to national data sets and the goals of Healthy People 2000. We found that minority women seen both in community health centers and within the community had many cardiovascular risk factors (41-45% had hypertension, 24-29% had cholesterol > 200 mg/dL, and 49-56% had a body mass index of >27.3 kg/m(2)). Women reported that they received low rates of counseling on healthy behaviors but generally received breast and cervical cancer screening. Forty-three percent of women who were interviewed in the community had no health insurance and these women were less likely to have received a Papanicolaou test or mammogram than insured women. Lack of insurance did not predict cancer screening for women already being seen in the community health clinic.

Home uterine activity monitoring in the prevention of very low birth weight.

OBJECTIVES: Despite controversy regarding the efficacy of home uterine activity monitoring (HUAM), it is currently licensed for detection of preterm labor in women with previous preterm deliveries. In practice, however, it is being more widely utilized in an effort to prevent preterm delivery. This study seeks to determine which group of mothers delivering very low birth weight (VLBW) infants would have qualified for HUAM given three different sets of criteria and in which women it could have been used to help prolong gestation. METHODS: The authors reviewed the medical records of mothers of VLBW infants born in five U.S. locations (N = 1440), retrospectively applying three sets of eligibility criteria for HUAM use: (a) the current FDA licensing criterion for use of HUAM, a previous preterm birth; (b) indication for HUAM commonly cited in published reports; (c) a broad set of criteria based on the presence of any reproductive or medical conditions that might predispose to premature delivery. The authors then analyzed the conditions precipitating delivery for each group to determine whether delivery might have been prevented with HUAM and tocolytic therapy. RESULTS: Only 4.4% of the total group of women delivering VLBW infants would have been eligible for HUAM under the FDA criterion and might potentially have benefited from this technology. If extremely broad criteria had been applied to identify those eligible for monitoring, under which almost 80% of all women who delivered VLBW infants would have been monitored, only 20.3% of the total group would have been found eligible and would potentially have benefited. If such broad criteria were applied to all pregnant women, a sizable proportion of pregnancies would be monitored at great expense with small potential clinical benefit. CONCLUSIONS: Because VLBW births are usually precipitated by conditions that are unlikely to benefit from HUAM, this technology will have little impact on reducing VLBW and neonatal mortality rates. More comprehensive preventive strategies should be sought.

The impact of extreme prematurity and congenital anomalies on the interpretation of international comparisons of infant mortality.

OBJECTIVE: To identify the potential impact that different definitions of live births and practice patterns have on infant mortality rates in England and Wales, France, Japan, and the United States. METHODS: United States data were obtained from the 1986 linked national birth-infant death cohort, and those for the other countries came from either published sources or directly from the Ministries of Health. RESULTS: In 1986 in the United States, infants weighing less than 1 kg accounted for 36% of deaths (32% white and 46% black); 32% resulted from fatal congenital anomalies. These rates were much higher in both categories than in England and Wales in 1990 (24 and 22%, respectively), France in 1990 (15 and 25%, respectively), and Japan in 1991 (9% for infants weighing less than 1 kg, percentage of fatal congenital anomalies unknown). These cases are more likely to be excluded from infant mortality statistics in their countries than in the United States. CONCLUSIONS: In 1990, the United States infant mortality rate was 9.2 per 1000 live births, ranking the United States 19th internationally. However, infant mortality provides a poor comparative measure of reproductive outcome because there are enormous regional and international differences in clinical practices and in the way live births are classified. Future international and state comparisons of reproductive health should standardize the definition of a live birth and fatal congenital anomaly, and use weight-specific fetal-infant mortality ratios and perinatal statistics.

The role of obstetrical medical technology in preventing low birth weight.

Technology plays an important role in the practice of medicine, and it is essential that controlled clinical trials be conducted before new technologies are widely disseminated. In this article, information from the medical literature is summarized and critiqued for several common obstetric technologies which are aimed at reducing the incidence or sequelae of low birth weight and preterm birth. These technologies include home uterine activity monitoring, tocolytic drugs to suppress uterine contractions, corticosteriods to accelerate fetal lung maturity, bed rest to prevent preterm delivery, delivery methods, multifetal pregnancy reduction, and cervical cerclage. A major challenge to the practice of medicine is to find effective ways to modify physician behavior to encourage the use of proven, effective technologies, and discourage the use of unproven, ineffective technologies. Despite widespread use, most obstetrical technologies appear to have had little impact on reducing the incidence of low birth weight or preterm births, as rates of low birth weight and preterm birth have not decreased appreciably in the past 25 years. Uncovering the basic mechanisms responsible for the onset of preterm labor will undoubtedly facilitate the discovery of new technologies to prevent low birth weight and preterm births.

The Human Genome Project: implications for the practicing obstetrician.

The Human Genome Project is an international effort to discern the complete genetic makeup of human beings. The isolation and characterization of genes will offer tremendous opportunities for disease detection, diagnosis, screening, prevention, and counseling. Advances in genetic research are occurring simultaneously with the development of new techniques for prenatal genetic testing. Use of gene therapy in humans likely will lag behind our ability to detect genetic disorders. Consequently, obstetricians will be forced to face some difficult medical, ethical, and social challenges. The possibility of a national cystic fibrosis screening program is an example of the complex problems we will face as new genes are described. The obstetric community needs to participate actively in the debate surrounding the ethical and legal implications of the Human Genome Project. We need to establish clinical standards and use our professional organization to act as a resource for clinicians, the public, and legislatures. Because of the increased requirement for genetic counseling, we recommend an expansion of genetics training for residents and clinicians and the development of computer-based interactive video programs for genetic counseling.

Removal of retained intrauterine contraceptive devices in pregnancy.

Using real-time ultrasound and clinical expertise gained from chorionic villus sampling, we describe a technique for ultrasound-guided intrauterine device removal in those cases in which the string is not visible. Utilizing a stone clamp for intrauterine manipulation, we were easily able to extract the device without interrupting the pregnancy. We concur with recent recommendations advocating all intrauterine devices can be removed if pregnancy termination is declined.

PIP: Physicians at leading hospitals in Boston, Massachusetts were able to remove a retained IUD from 3 women who were in their 1st trimester of pregnancy. They took cervical cultures to test for chlamydia, beta-hemolytic Streptococcus, and gonococcus before attempting to remove the IUD. They used a 3.5 MHz transducer from an Acuson 128 machine to perform a transabdominal ultrasound scan. The physicians used a transcervically introduced stone clamp to retrieve the IUD. The technique was like that used for transcervical chorionic villus sampling. The 1st case was a 36-year old gravida 3 with a copper-7 IUD whose string had disappeared from sight. She was 8 weeks' gestation. The IUD was laying below the gestational sac. She delivered a full-term healthy infant weighing 3348 gm. The 2nd patient was a 27-year old Chinese woman who had been pregnant before, but had no living children. She was 9 weeks' gestation and had a stringless metal ring IUD. It was in the lower uterus. She experienced some bleeding afterwards. She did not experience any difficulties during the rest of her pregnancy and delivered a full-term infant (2665 gm). The 3rd case was also a Chinese woman with a metal ring IUD. She was gravida 2 para 1 at 10 weeks' gestation. Like the other Chinese woman, the IUD was in the lower uterus. She experienced bleeding throughout the 1st trimester. Nevertheless, at 40 weeks' gestation, she had a healthy 2665 gm infant. This method is best accomplished by someone skilled in in utero manipulation as is done with chorionic villus sampling. The physicians recommend that other physicians should try to remove a retained IUD using this technique no matter its location, type, or the presence of a visible string or not, if the patient indeed wants to continue the pregnancy.

Cancer-related maternal mortality in Massachusetts, 1954-1985.

Cancer-related maternal mortality is a rare event. We report the first population-based study of this issue using data collected by the Committee on Maternal Welfare of the Massachusetts Medical Society between 1954 and 1985. The incidence of cancer-related maternal mortality during the study period fell from 3.16 to 0 per 100,000 live births. The most common cancer-associated maternal deaths were due to central nervous system tumors and hematological cancers. To determine the effects of pregnancy on cancer mortality, we compared our data with figures from the Connecticut Register of Mortality for Women aged 15-44. In the pregnant group there was a significantly higher incidence of mortality due to central nervous system tumors and a significantly lower incidence of mortality due to breast cancer. The data suggest that pregnancy may not be contraindicated for a woman with a history of breast cancer, but may be contraindicated for a woman with a history of a central nervous system tumor.

Intrapartum and delivery room management of the very low birthweight infant.

The management of a pregnant woman in premature labor is a challenge. The roles of the perinatologist as well as support people is discussed in this article.

The nonstress test. Transmission from the home.

The Genesis Fetal Monitor System, which includes a recorder, a communication module and a receiver system, accurately and rapidly transmits a complete antenatal fetal monitor tracing over standard telephone lines and duplicates the original tracing at the receiver center. Transmission time for a 20-minute nonstress test is less than 2 minutes. The time required to generate a duplicate strip is less than 30 seconds. In all cases in this study the original and generated tracings were superimposable. No significant technical problems were encountered. Bioelectronic fetal assessment can be performed from a nonhospital setting, including the patient's home, with immediate interpretation of the tracing by skilled consultants.

Anesthetic-related maternal mortality, 1954 to 1985.

This is a population-based study of the safety of obstetrical anesthesia in the Commonwealth of Massachusetts between 1954 and 1985. We used data collected by the state Committee on Maternal Mortality, which was founded in 1941. There were a total of 37 maternal deaths during the study period due to anesthetic-related complications. During the same time period, there were 886 maternal deaths. Thus, anesthetic-related mortality comprised 4.2% of all deaths, and the mortality rate was 1.5 per 100,000 live births between 1955 and 1964, 1.5 per 100,000 live births between 1965 and 1974, and 0.4 per 100,000 live births between 1975 and 1984. In the first decade of this study, aspiration during administration of a mask anesthetic was the primary cause of death. During the second decade, cardiovascular collapse associated with regional anesthesia was the primary cause of death. During the last decade of this study, all deaths were associated with general endotracheal anesthesia. As a result of this study and having identified the changes in the standard of care in Massachusetts that led to the reduction in maternal mortality, we offer recommendations to further improve the safety of anesthesia for childbirth in this country.

Ultrasonographic diagnosis of incompetent cervix. A case report.

The ultrasonographic findings of an incompetent cervix, the protrusion of the lower pole of the fetal membranes through the dilated internal os, may precede physical changes in the cervix. The symptoms at that time may be nonspecific. As this case report indicates, we believe that action--either close observation, conservative treatment or surgical intervention--should follow the detection of this condition.

Cesarean birth rate: small-geographic-area analysis.

Population-based analysis of cesarean section rates within 172 geographic areas in the Commonwealth of Massachusetts during fiscal year 1985 revealed a nearly normal distribution of observed-to-expected rates, implying that the forces that compel obstetricians to perform this surgical procedure are pervasive. However, a small number of areas were identified in which the number of procedures performed was significantly different from the state mean. During fiscal years 1982 to 1985, certain geographic subgroups consistently demonstrated incidence rates significantly greater than the state mean. Although variation (either overutilization or underutilization) from the state rate is not synonymous with inappropriate care, those physicians within the identified geographic areas must take responsibility for ascertaining the explanation for the variance.

Hemorrhage, infection, toxemia, and cardiac disease, 1954-85: causes for their declining role in maternal mortality.

Hemorrhage, infection, toxemia, and cardiac disease are no longer the leading causes of maternal death. We studied factors causing their decline in incidence using data collected by the Committee on Maternal Welfare of the Massachusetts Medical Society between 1954 and 1985. The dramatic decline in incidence of these conditions in the Commonwealth during the study period appears to have been due to both legislative actions and improvements in medical practice. The legislative actions included licensing of maternity services, blood banks, and legalization of abortion. Cardiac-related mortality has declined due to a reduction in the prevalence of rheumatic heart disease. Changes in clinical practice that stand out were the aggressive control of the hypertensive component of toxemia leading to a reduced incidence of intracranial hemorrhage, the prompt recourse to blood transfusion for hemorrhage, and the use of broad spectrum antibiotics.

Cesarean section-related maternal mortality in Massachusetts, 1954-1985.

We analyzed the data of the Maternal Mortality Committee of the Massachusetts Medical Society to investigate cesarean section-associated maternal deaths. Between 1954-1985, the number of cesarean section-related deaths per 100,000 live births did not significantly change despite a quadrupling of the cesarean section rate. Between 1976-1984, there were 649,375 births and 121,217 cesarean sections in the state. Seven deaths were directly related to cesarean section, a rate of 5.8 per 100,000 cesarean sections. In contrast, the rate for vaginal deliveries was 10.8 per 100,000 vaginal deliveries. We conclude that the risk of maternal death from cesarean section is low.

Risk factors for Erb-Duchenne palsy.

The risk factors associated with the occurrence of Erb-Duchenne palsy were examined. Of 22 palsies, 18 were noted among 32,088 nondiabetic gravidas (0.56 per 1000) compared with four among 380 diabetic gravidas (10.5 per 1000), a statistically significant difference. One in six infants of diabetic gravidas who sustained shoulder dystocia experienced an Erb-Duchenne palsy. The incidence of precipitate second-stage labors was high (31.8%) among those infants who experienced the neurologic complication. This labor abnormality is not preventable and may contribute, in many ways, to the neurologic complication. Although recently graduated (less than four years' postresidency training) obstetricians, especially if placed in a high-volume practice, were more likely to experience this adverse outcome than more experienced physicians, even the most senior clinicians delivered infants who were affected.

Acquired immunodeficiency syndrome: suggested protocol for counseling and screening in pregnancy.

The Centers for Disease Control (CDC) has recorded 35,900 cases of acquired immunodeficiency syndrome (AIDS) in the United States, including 2447 infected females, as of May 25, 1987. These cases include 503 children under the age of 13, of whom 80% were thought to have been affected through perinatal transmission. The prevalence of AIDS-related complex and human immunodeficiency virus in the United States is far greater than these numbers. The CDC has recommended screening those pregnant women with risk factors for human immunodeficiency virus. With the help of a wide range of professionals, we have developed a screening protocol for human immunodeficiency virus in pregnancy. In the first six months, 3-4% of prenatal patients used this counseling service, and 11 human immunodeficiency virus-positive women delivered. This paper discusses the medical and ethical issues that were raised and the problems that we faced in establishing this protocol.

The normal parturient's admission temperature.

The relationship between oral temperature taken at the time of admission and the duration of elapsed labor was evaluated. Onset of labor data revealed a diurnal distribution with an apogee at midnight to 2 AM and a nadir at 11 AM to noon. Temperature data ranged from 94.3 degrees to 99.7 degrees F (34.6 degrees to 37.6 degrees C). The mean temperature of 97.8 degrees +/- 0.8 degrees F (36.6 degrees +/- 0.44 degrees C) is significantly lower (p less than 0.001) than the clinical reference temperature of 98.6 degrees F (37.0 degrees C). A likely explanation is the coincidental admission time (early to late morning) and the nadir of the diurnal variation in temperature. Linear regression fitted to the data (after deletion of six hypothermic outliers) yielded the relationship: temperature = 97.8 degrees F + 0.0115 X duration of elapsed labor (temperature = 36.6 degrees C + 0.0064 X duration of elapsed labor) for which the correlation coefficient is not statistically significant.