1.
Clin Chim Acta
; 119(1-2): 115-9, 1982 Feb 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7060270
RESUMO
The activity of beta-glucuronidase was studied in the gastric aspirate from normal individuals, cases of duodenal ulcer with pyloric stenosis and carcinoma of the stomach. The optimum pH for the activity of this enzyme in the gastric aspirate is 4.0 to 5.5. Cimetidine, a H2-receptor antagonist, was administered orally to obtain the optimum pH for the enzyme activity, when the pH of the gastric aspirate was less than 4.0. It is observed that the enzyme activity in cases of carcinoma of the stomach is markedly elevated (p less than 0.01), when compared with other cases in this study. It is suggested that the elevated enzyme activity in the gastric aspirate could be used as a biochemical marker in the diagnosis of carcinoma of the stomach.