[Borderline mental disorders in parkinsonism patients and their drug correction]. / Psikhicheskie narusheniia pogranichnogo urovnia u bol'nykh parkinsonizmom i ikh medikamentoznaia korrektsiia.

70 patients with vascular parkinsonism (VP) were investigated. The total group of patients was divided into several groups depending upon: a) the forms of disease (with typical or atypical forms of disease), b) the different syndromes (with bradykinesia and rigidity or tremor). Borderline psychic disorders manifested as a light depression with cognitive disturbances and personality changes. Hamilton Depression Rating Scale and Hachinski Ischemic Score were administered to assess the severity of depression and cognitive disturbances, respectively. Patients were treated with cholinolytics and L-DOPA-containing preparations. After treatment the clinical improvements were observed in patients with typical (86.8%) and atypical (93.7%) forms of VP (difference between groups failed to reach statistical significance), with tremor (93.3%) and rigidity (83.7%) syndromes (difference between groups reached statistical significance, p < 0.05). Efficacy of antidepressant treatment reached 90.5% in patients with typical and in 100% atypical forms of VP, respectively. The efficacy was the same in patients with rigid forms of VP. Antidepressant treatment significantly elevated the level of social adaptation of patients with VP.

Therapy of depressions in post-stroke patients.

In a study of 90 patients with post-stroke depression the Hamilton Depression Scale was used together with a clinical psychopathological study. One group of patients was treated with amitriptyline, another with minor tranquilizers (seduxen), and the third (controls) received neither antidepressants, nor tranquilizers. Only treatment in the first group was effective, i.e. depressions were reduced after therapy with amitriptyline So amitriptyline was demonstrated to be the most effective drug of choice in the treatment of non-psychotic post-stroke depressions.

[Psychopathologic syndromes in patients with a history of stroke (characteristics of the clinical picture, course and rehabilitation)]. / Psikhopatologicheskie sindromy u bol'nykh, perenesshikh insul't (osobennosti kliniki, techeniia reabilitatsii).

Four hundred patients were studied in acute, early rehabilitation and distant periods of stroke. The investigation showed some peculiarities of psychopathology in cerebral stroke and proved their correction feasible. The data evidence that rehabilitative, psychotherapeutic and psychocorrective approaches combined with drug therapy could yield a better therapeutic result than usage of drugs only in stroke patients.