[Use of molecular genetic diagnostic methods in periodontology and implantology].

The authors have studied the species-specific composition of major periodontopathogenic bacteria (P. gingivalis, P. intermedia, B. forsythus, A. actinomycetemcomitans, and T. denticola), by applying the Russian reagent kit developed and made by HPF "GENETECH", and some fungi, microorganisms, and viruses among the Moscow Region inhabitants with chronic generalized periodontitis in 2006-2008. The studies have shown it possible to use molecular genetic methods for diagnosis, drug therapy monitoring, and epidemiological studies in periodontology and implantology.

[Selection of diagnostically significant parameters in integral evaluation of the effects of occupational biologic and chemical hazards]. / Otbor diagnosticheski znachimykh pokazatelei pri integral'noi otsenke vozdeistviia proizvodsvennykh faktorov biologicheskoi i khimicheskoi prirody.

Clinical and immunologic study including evaluation of immune state, allergic reactivity and adaptation covered 1174 workers engaged into microbiologic synthesis of proteins (production of proteovitamin concentrates and hydrolytic yeast) and 543 ones working at chemical enterprises in contact with gases irritating respiratory tract, with isocyanate and acryl compounds. Homeostasis of the examinees was assessed by means of an integral parameter, and the parameter's limits were defined for the diseases under study. The research determined diagnostically valuable parameters for some entities diagnosed in the examinees. The suggested approach could benefit early diagnosis and prophylaxis of diseases associated with occupational hazards.

[Information content of immunologic parameters in the evaluation of the effects of hazardous substances]. / Informativnost' immunologicheskikh pokazatelei pri otsenke deistviia vrednykh veshchestv.

Clinical and immunologic examination including 1 and 2 level tests covered 429 staffers of chemical enterprises and 1122 of those engaged into microbiological synthesis of proteins, both the groups exposed to some irritating gases and isocyanates. Using calculation of Kulbak's criterion, the studies selected informative parameters to diagnose immune disturbances caused by occupational hazards. For integral evaluation of immune state, the authors applied general immunologic parameter, meanings of which can serve as criteria for early diagnosis of various immune disorders and for definition of risk groups among industrial workers exposed to occupational biologic and chemical hazards.