General publics' perception toward COVID-19 vaccines in Afghanistan, 2021.

As of August 2021, less than 5% of the total population in Afghanistan has been fully vaccinated against COVID-19. Concerns remain regarding low uptake of the vaccine due to several factors. This study was conducted to understand the perception of the public on COVID-19 and its vaccines in Afghanistan. This was a formative study using qualitative method that included FGDs with vaccination target groups and KIIs, using interview guides in local languages in 12 provinces with 300 participants during May-June 2021. Verbatim transcripts were created, and a deductive thematic analysis was conducted with transcripts after the key themes and sub-themes were developed and reviewed. Totally 24 FGDs with male and female COVID-19 high-risk groups, 12 KIIs with EPI managers, and 12 KIIs with prison heads were conducted. Key themes included awareness and perception about COVID-19, its vaccination, motivators for getting vaccinated, barriers for not getting vaccinated, and sources of information. Awareness about the COVID-19 was high in urban areas compared to rural areas. Almost 60% of the participants considered the COVID-19 vaccine effective. However, participants expressed their concerns regarding rumors and misconceptions on content, source, effectiveness, and side effects of the vaccine in their communities. Based on the study results, many participants expressed accurate knowledge about the COVID-19 disease and its vaccines. Significant barriers including misinformation, conspiracy theories, and fear of side effects persist. Collaboration between stakeholders and increasing awareness and engagement of communities about the benefits and effectiveness of the vaccines should be considered crucial.

Predictors of Mothers' Care Seeking Behavior for Common Childhood Illnesses: Findings From the Afghanistan Health Survey 2015.

BACKGROUND: Mothers' care seeking behavior for childhood illness is a key factor of utilizing healthcare for children. We examined predictors of mothers' care seeking for common childhood illnesses. METHODS: This was a cross-sectional study, using data from the Afghanistan Health Survey (AHS) 2015. Data were used from women who sought healthcare for their unwell children. The women were asked whether their children were sick with fever, cough, faster breathing, or diarrhea in the past 2 weeks. The outcome variable was defined as whether the mother sought healthcare for her unwell child from a public clinic, a private clinic, or from a pharmacy store. The Andersen's healthcare seeking behavior model was used and multinomial regression analysis applied. RESULTS: There were 4979 women, aged 15-49 years, whose under-5 children were sick in the past 2 weeks. Thirty-nine percent of women sought healthcare for their children from a health provider. Mother's age, child's age, child's sex, socioeconomic status, mothers' perceived severity of childhood illness, and number of under-5 children were predictors of mothers' care seeking behavior. The likelihood of healthcare seeking was lower for older children (Adjusted odds ratio [OR] [95% CI]: 0.51 [0.37-0.70] from public clinics; 0.33 [0.23-0.47] from private clinics; 0.36 [0.22-0.61] from pharmacy stores), and for girls (Adjusted OR [95% CI]: 0.74 [0.59-0.93] from private clinics). The likelihood of healthcare seeking was greater for children whose mothers knew symptoms of childhood illness (Adjusted OR [95% CI]: 2.97 [1.44-6.16] from public clinics; 7.20 [3.04-17.04] from pharmacy stores). The likelihood of healthcare seeking for children was greater in older mothers (Adjusted OR [95% CI]: 1.54 [1.11-2.12]). It was less likely for the mothers who have more children to seek healthcare for their children (Adjusted OR [95% CI]: 0.53 [0.43-0.65] from public clinics; 0.61 [0.48- 0.79] from private clinics; 0.51 [0.37-0.69] from pharmacy stores). CONCLUSION: Health policy-makers may opt to use our findings, particularly mothers' knowledge (perceived severity) of symptoms of childhood illness to develop interventions to enhance timely assessment and effective treatment of common preventable childhood illnesses.

Knowledge, attitudes, practice of people toward the COVID-19 pandemics, and its impact in Afghanistan.

COVID-19 pandemic disrupted the social and economic norms. Knowledge, Attitude and Practices studies are used to address the information gap for further strategic decision making to control the pandemic. This study aimed to find the level of Knowledge, Awareness, Attitudes, and behavioral practices of the people of Afghanistan about the COVID-19 and its impact on health and socio-economic dimension of their routine lives. We used a cross-sectional method with two stage sampling design. Data analysis was performed using SPSS v.20. The survey focused on adults including men and women all over the country to represent the country, including the urban and rural areas. Most of the respondents are in the age group of 21-30 years (46.5%); 60.15% of the participants are married. Almost 75% of females and 84% of males were literate and most participants have a bachelor's degree (34%). More than 80% of participants knew they can prevent themselves from contacting COVID-19 through hand washing frequently with soap and water and wearing a mask. More than 80% of participants responded that they would go for a lab test for detection of the virus as well as COVID-19 vaccination if it is available. Almost 35% reported always wearing a mask to prevent COVID-19 transmission; more than half of participants always wash their hands, more than 60% of them do not touch their eyes, nose, and mouth frequently. Nearly 60% of participants indicated that their household had problems satisfying food needs partly during the COVID-19 pandemic. Nearly half of participants believed that the government was successful in applying lockdown measures and in awareness rising (56.8 and 69.8%). The study findings provide some useful insight about the KAP of communities in Afghanistan, which could assist policy makers in public health to design and implement interventions based on the information gaps reported.

Public health workers' knowledge, attitude and practice regarding COVID-19: the impact of Field Epidemiology Training Program in the Eastern Mediterranean Region.

BACKGROUND: This study aimed to compare knowledge, attitude and practice (KAP) regarding COVID-19 between public health workers (PHWs) attended field epidemiology training program (FETP-trained) and those who did not attend FETP (non-FETP trained). METHODS: Multi-country cross-sectional survey was conducted among PHWs who participated in COVID-19 pandemic in 10 countries at EMR. Online questionnaire that included demographic information, KAP regarding COVID-19 pandemic was distributed among HCWs. Scoring system was used to quantify the answers, bivariate and Multivariate analysis performed to compare FETP-trained with non-FETP trained PHWs. RESULTS: Overall, 1337 PHWs participated, with 835 (62.4%) < 40 years of age, and 851 (63.6%) males. Of them, 423 (31.6%) had FETP, including that 189 (44.7%) had advanced level, 155 (36.6%) intermediate and 79 (18.7%) basic level training. Compared with non-FETP trained, FETP trained were older, having higher KAP scores. FETP participation was low in infection control, and PH laboratories. KAP mean scores for intermediate level attendees are comparable to advanced level. CONCLUSIONS: FETP-trained are having better KAP than non-FETP PHWs. Expanding the intermediate level, maintain the Rapid Response training and introduce the laboratory component are recommended to maximize the benefit from FETP. Infection control, antimicrobial resistance and coordination are areas where training should include.

Profile of risk factors for noncommunicable diseases in major cities of Afghanistan: WHO STEPwise approach.

BACKGROUND: Noncommunicable diseases (NCDs) are a major public health problem worldwide. Despite improvement in the health situation, Afghanistan's health indicators are the worst in the Region. About 37% of Afghan adults die due to NCDs. AIMS: We aimed to estimate the proportion of major risk factors for NCDs in Afghanistan. METHODS: We analysed the dataset of studies conducted in 5 provinces, Kabul, Balkh, Hirat, Nangarhar and Kandahar, during 2013-2015, using the WHO STEPwise approach to NCD surveillance. This involved multistage cluster sampling from urban citizens aged 25-70 years. EpiInfo, version 7, and SPSS, version 20, were used for data management. RESULTS: In total, 5897 records were included in the analysis; 54% were females. Mean age was 39.56 (standard deviation12.29) years; illiteracy rate was 61.5% and 83.2% were married. Smoking and snuff use was 8% and 11.1% respectively. On average the subjects were consuming fruits 2.76 and vegetable 3.85 days per week. Overweight, general and abdominal obesity was 19%, 33.7% and 57.1% respectively. Typically, 32.4% had high blood pressure and 12.5% had high blood sugar. CONCLUSIONS: The modifiable risk factors of NCDs were prevalent in the major cities of the country. Their identification is vital in attempting to focus on prevalence of NCDs in urban cities. Tailored interventions are needed to focus on NCDs in Afghanistan.

Epidemiology of blood-borne viral infections in Afghanistan.

Although a few studies have been done on transmissible blood-borne viral infections in high-risk groups, little attention has been given to assessing the infection status of the general population in Afghanistan. To investigate the epidemiological status in the general population, we tested the serological markers of hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis delta virus (HDV), human immunodeficiency virus 1 (HIV-1) and human T-cell leukemia virus (HTLV) infections. In total, 492 samples were selected randomly from Nangarhar, Herat, Mazar-e Sharif, Kandahar, and Kabul from subjects between 25 and 70 years old. The samples were tested for the presence of HBsAg, anti-HBs, anti-HBc, anti-HDV, anti-HCV, anti-HIV-1 and anti-HTLV I/II antibodies using chemiluminescent immunoassays on Abbott Architect automated platforms. In addition, 220 HBsAg-positive samples identified among 5897 samples from the general population of the same regions of Afghanistan were included in the study and tested for both HBsAg and anti-HDV to investigate HDV prevalence in the country. Viral loads of HBV, HCV and HDV were determined in all seropositive samples using Ampliprep/Cobas TaqMan HBV, HCV, Test Roche (CA, USA), and an in-house method, respectively. Out of 492 samples, 31 (6.3%), 136 (27.6%) and 149 (30.3%) were found to be positive for HBsAg, anti-HBs and anti-HBc, respectively. Anti-HDV positivity was detected in five (2.1%) out of 234 HBsAg-positive samples (including 14 of the randomly selected samples that were not among the 220 previously identified as HBsAg positive). Only eight out of 492 (1.6%) subjects were positive for anti-HCV antibodies. Seven out of 489 (1.4%) were positive for anti-HIV-1 antibodies, and three out of 466 cases (0.6%) were positive for anti-HTLV I/II antibodies. These results suggest that Afghanistan is an intermediate endemic region for HBV, HDV and HCV infection. The prevalence of HIV-1 seems to be significantly higher than the global prevalence and that of the eastern Mediterranean region. In addition, the HTLV I/II screening results suggest that these viruses should be monitored in Afghanistan to confirm the trend observed in the current study.

Challenges on-the-way of nursing administration at public hospitals in Kabul, Afghanistan.

PURPOSE: The purpose of this study was to determine the challenges faced by the nursing administration at public hospitals in Kabul, Afghanistan. METHODS: A cross-sectional study design was used to recruit 86 nursing managers and head nurses from 17 public hospitals in Kabul. The participants rated the frequency of 13 challenges that hinder their performance. RESULTS: There were 14 nursing managers and 72 head nurses in the study. Almost 80% of the participants were male with the majority falling in the 35-44 year age bracket. Both nursing managers and head nurses were equally affected by all 13 challenges, except the lack of recognition where head nurses were affected more than the nursing managers (p = .003). The most frequent challenges for both were staff absenteeism and then too many responsibilities. CONCLUSION: There are multiple challenges that hinder the performance of nursing administration that need to be addressed through appropriate national policy and strategies. IMPLICATIONS FOR NURSING MANAGEMENT: The findings of this study can inform policy makers and draw their attention to overcome the challenges faced by nursing management. This will ultimately improve satisfaction leading to improved patient and organisational outcome. The national policy and strategy should address areas that could enable nurses to maintain a balance between household and professional responsibilities; and also encourage the enrolment of female nurses in the profession.

Burden of Hypertension in the Capital of Afghanistan: A Cross-Sectional Study in Kabul City, 2015.

Background. This study had the objective to assess the prevalence and associated factors of hypertension in an urban setting, Kabul city, Afghanistan. Materials and Methods. The World Health Organization's STEP-wise approach was adopted and used in Kabul in November 2015. The study analyzed a sample of 1172 adults in the age group of 25-70 years. Demographic, socioeconomic, and behavior data were collected using a structured questionnaire. Fasting venous blood sample was collected to assess the lipid profile and fasting blood sugar. Results. The study showed that the prevalence of hypertension among adult Kabul citizens was 32.3%. From this figure, 599 (51.1%) were females and 573 (48.9%) males with a mean age of 38.6 ± 12.2 years. Illiteracy rate was 49.6% and 77.5% were married. Smoking in adults were 8.1% and mouth snuff users were 9.8%. More than half (57.6%) of the study respondents were overweight and obese and 9.1% were recorded having raised blood sugar. In the multivariate logistic regression analysis, age, general obesity, central obesity, smoking, moderate physical activity, and taking fruits 3 days or less weekly were statistically significant predictors of hypertension. Conclusions. Burden of hypertension is increasing in main urban settings in Afghanistan. Integrated intervention focusing in main modifiable risk factors is needed to detect and prevent hypertension.

Prevalence of hypertension and associated factors in Jalalabad City, Nangarhar Province, Afghanistan.

BACKGROUND: Hypertension affects an estimated one billion people, worldwide. It is a public health challenge characterized by increased morbidity, mortality, as well as cost to the community and health systems. The goal of this study is to determine the prevalence of hypertension and characterize associated risk factors in an urban setting in Afghanistan. METHODS: A cross-sectional study of adults aged 25-65 years was conducted in Jalalabad city from May to June 2013 using the World Health Organization STEPwise approach to surveillance (WHO STEPS). A multistage technique was used to enroll 1,200 participants in the study. Demographic and socio-economic variables were collected via individual interviews using the WHO STEPS survey, after which blood samples were collected using a locally developed standard operating procedure (SOP). Bivariate and multivariable analyses were performed to explore the association between hypertension and associated factors. RESULTS: A total of 1,180 adults (40% males, 60% females) of 25-65 years of age were surveyed. The response rate was 98.5 % and the prevalence of hypertension was 28.4. Independent risk factors of hypertension were found to be: age ≥ 50 (AOR = 3.42, 95% CI: 2.50 - 4.76); sex (AOR = 0.58, 95% CI: 0.38 - 0.88); obesity (AOR = 2.1, 95% CI 1.49 - 2.94); and diabetes (AOR = 1.75, 95% CI: 1.10 - 2.79). Independent protective factors were physically demanding occupations (AOR = 0.55, 95% CI: 0.36 - 0.85); physical activity itself (AOR = 0.69, 95% CI: 0.47 - 0.99) and consuming more vegetables (AOR = 0.59, 95% CI: 0.38 - 0.93). CONCLUSION: This urban setting in Afghanistan evidenced a high prevalence of hypertension; age, obesity, and diabetes were identified as risk factors and physical activity and consuming more vegetables were protective. These findings have implications for future public health intervention and clinical efforts.

Prevalence and predictors of adult hypertension in Kabul, Afghanistan.

BACKGROUND: The prevalence of hypertension is rising worldwide with an estimated one billion people now affected globally and is of near epidemic proportions in many parts of South Asia. Recent turmoil has until recently precluded estimates in Afghanistan so we sought, therefore, to establish both prevalence predictors in our population. METHODS: We conducted a cross-sectional study of adults ≥40 years of age in Kabul from December 2011-March 2012 using a multistage sampling method. Additional data on socioeconomic and lifestyle factors were collected as well as an estimate of glycaemic control. Bivariate and multivariable analyses were undertaken to explore the association between hypertension and potential predictors. RESULTS: A total of 1183 adults (men 396, women 787) of ≥ 40years of age were assessed. The prevalence of hypertension was 46.2% (95% CI 43.5 - 49.3). Independent predictors of hypertension were found to be: age ≥50 (OR = 3.86, 95% CI: 2.86 - 5.21); illiteracy (OR = 1.90, 1.05 - 1.90); the consumption of rice >3 times per week (OR = 1.43, 1.07 - 1.91); family history of diabetes (OR = 2.20, 1.30 - 3.75); central obesity (OR = 1.67, 1.23 - 2.27); BMI ≥ 30 Kg/meter squared (OR = 2.08, 1.50 - 2.89). The consumption of chicken and fruit more than three times per week were protective with ORs respectively of 0.73 (0.55-0.97) and 0.64 (0.47 - 0.86). CONCLUSIONS: Hypertension is a major public health problem in Afghan adults. We have identified a number of predictors which have potential for guiding interventions.

Concurrent Brucellosis and Q Fever Infection: a Case Control Study in Bamyan Province, Afghanistan.

BACKGROUND: More than 500,000 people are affected by brucellosis each year while the incidence of Q fever is poorly recorded. Consistent outbreaks of brucellosis have been reported in Afghanistan, affecting social and economic life. This study aimed to determine the means of propagation of brucellosis and Q-fever and establish appropriate control measures for both. METHODS AND MATERIALS: An outbreak of 1,317 cases of brucellosis and Q fever was investigated from May 2011 to the end of 2012 in Bamyan province of Afghanistan. A total of 100 cases were selected by random sampling with equal number of neighbor controls. Data were collected through structured questionnaire. RESULTS: The average age was 30 years ±14 years. Of those sampled, 62% were female, 38% were male, and resided in three districts: Punjab, Yakawlang and Waras. Using multivariate analysis, being a housewife (OR=7.36), being within proximity of kitchens to barns (OR= 2.98), drinking un-boiled milk (OR= 5.26), butchering (OR= 3.53) and purchasing new animals in the last six months (OR= 3.53) were significantly associated with contraction of brucellosis and Q fever. CONCLUSION: Health educators should focus on families dealing with animals, especially on females. Pasturing, healthy milking, dunging, and slaughtering practices, along with use of safe dairy products should be the focus of preventive measures.

Prevalence of Risk Factors for Non-Communicable Diseases in the Adult Population of Urban Areas in Kabul City, Afghanistan.

BACKGROUND: Non-Communicable diseases (NCDs) are a major global problem. This study aims to estimate the prevalence of common risk factors for NCDs among the adult population in urban areas of Kabul city, Afghanistan. METHODS AND MATERIALS: This study was conducted from December 2011 through March 2012 and involved a survey of 1169 respondents, aged 40 years and above. Multistage cluster sampling was used for participant selection, followed by random sampling of the participants. The World Health Organization STEPwise approachfor Surveillance (STEPS) was modified and used for this study. RESULTS: The overall prevalence of smoking was 5.1% (14.7% men versus 0.3% women) and using mouth snuff was 24.4% in men and 1.3% in women. The prevalence of obesity and hypertension were 19.1% and 45.2 % in men and 37.3% and 46.5% in women. Prevalence of diabetes was 16.1% in men and 12% in women. The overall prevalence of obesity, hypertension and diabetes mellitus was 31.2%, 46% and 13.3%, respectively. On average, subjects consumed 3.37 servings of fruit and 2.96 servings of leafy vegetables per week. Mean walking and sitting hours per week (as proxies for physical activity) were 19.4 and 20.5, respectively. A multivariate model demonstrated that age was a significant risk factor for obesity (OR=1.86), diabetes (OR=2/09) and hypertension (OR=4.1). Obesity was significantly associated with sex (OR=1.65). CONCLUSION: These results highlight the need for interventions to reduce and prevent risk factors of non-communicable diseases in urban areas of Kabul City, Afghanistan.

Occurrence of acute respiratory infection, diarrhea and jaundice among Afghan pilgrims, 2010.

BACKGROUND: Annually 30,000 Afghans attend the Hajj in Saudi Arabia that is one of the largest mass gathering events in the world. We aimed to determine the prevalence of three syndromes of interest diarrhea, acute respiratory infections (ARI) and jaundice-among Hajjis gathering at the four transit sites in Afghanistan before, during, and after their voyage. METHODS: A total of 1659 Hajjis at four transit sites were selected and included a cross-sectional study. Information was collected prior Hajjis departure and upon their return from Saudi Arabia regarding demographics and experience of diarrhea, ARI and jaundice. Standardized case definitions were used for the three health outcomes of interest. RESULTS: The occurrence of diarrhea and jaundice remained constant over time. However, ARI increased from 1.4% at pre-transit to 4% at transit area and 37% during the Hajj. ARI rates among residents from the Central and Northern regions of Afghanistan were significantly higher at the post-Hajj stage, at 50% and 69%, respectively. There was no difference in ARI by sex among Hajjis. CONCLUSIONS: There is a need to review the quality and effectiveness of the flu vaccine. Authorities should come up with the sound strategies to overcome ARI problems during Hajj.