Pachydermoperiostosis and Work Restrictions: A Case Report.

Pachydermoperiostosis (PDP) is a rare disease that mimics the clinical and radiographical manifestations of acromegaly. Therefore, it should be considered as one of the differential diagnoses in the evaluation of acromegalic patients. In this study, we discussed a case of PDP in a 24-year-old simple worker working in a food industry factory and reviewed the work restrictions caused by the complications of the disease.

Molecular View on Mechanical Reinforcement in Polymer Nanocomposites.

The microscopic origin of mechanical enhancement in polymer nanocomposite (PNC) melts is investigated through the combination of rheology and small-angle neutron scattering. It is shown that in the absence of an extensive particle network, the molecular deformation of polymer chains dominates the stress response on intermediate time scales. Quantitative analyses of small-angle neutron scattering spectra, however, reveal no enhanced structural anisotropy in the PNCs, compared with the pristine polymers under the same deformation conditions. These results demonstrate that the mechanical reinforcement of PNCs is not due to molecular overstraining, but instead a redistribution of strain field in the polymer matrix, akin to the classical picture of hydrodynamic effect of nanoparticles.

Assembly of Indole Cores through a Palladium-Catalyzed Metathesis of Ar-X σ-Bonds.

We describe the development of a new method for construction of highly substituted indole scaffolds through the strategic utilizing of the metathesis of Ar-X σ-bonds based on the dynamic nature of palladium-based oxidative addition/reductive elimination. A suitable and simple catalytic system has provided an appropriate platform for a productive ligand exchange and consecutive carbopalladation/C-H activation/amination of phosphine ligands with alkynes and aromatic/aliphatic amines for construction of structurally diverse indoles.