RESUMO
Sialoblastoma is the most common epithelial tumor of the salivary gland. We report a case of congenital sialoblastoma arising in a minor salivary gland of the buccal mucosa of a male infant. After radiologic evaluation, an incisional biopsy was performed and then the mass was excised en bloc. Histologic features were both favorable and unfavorable. However, there was no recurrence for 5 months. In spite of a reported histologic grading system, the clinical course of isolated sialoblastoma is considered unpredictable. More published case reports of this rare tumor may enable histologic and clinical correlation in order to accurately predict prognosis.
Assuntos
Neoplasias Epiteliais e Glandulares/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/patologia , Bochecha/patologia , Intervalo Livre de Doença , Humanos , Recém-Nascido , Imageamento por Ressonância Magnética , Masculino , Mucosa Bucal/patologia , Neoplasias Epiteliais e Glandulares/congênito , Neoplasias Epiteliais e Glandulares/cirurgia , Prognóstico , Neoplasias das Glândulas Salivares/congênito , Neoplasias das Glândulas Salivares/cirurgia , Resultado do TratamentoRESUMO
A 77-yr-old man presented with marked peripheral blood and bone marrow plasmacytosis, marked hypergammaglobulinemia, and multiple autoantibodies. Serum protein immunofixation and immunophenotyping of bone marrow plasma cells by flow cytometry and immunohistochemistry disclosed polyclonal proliferation of plasma cells at various stages of differentiation. The presence of multiple autoantibodies in the patient's serum suggests that an autoimmune disease underlies the polyclonal proliferation of plasma cells.
Assuntos
Autoanticorpos/imunologia , Medula Óssea/patologia , Hipergamaglobulinemia/imunologia , Hipergamaglobulinemia/patologia , Plasmócitos/imunologia , Plasmócitos/patologia , Idoso , Antígenos CD/metabolismo , Proliferação de Células , Células Clonais , Citometria de Fluxo , Humanos , Hipergamaglobulinemia/metabolismo , Imunofenotipagem , Masculino , Plasmócitos/metabolismoRESUMO
Iron is the most important element in the body, essential for almost all types of cells, including brain cells. The role of iron in the brain has been known for years. Iron deficiency and iron excess have been associated with pathophysiology of different brain disorders. Iron deficiency has been reported to have a role in brain development and the pathophysiology of restless legs syndrome. Iron accumulation has been related to some neurologic disorders such as Alzheimer disease, Parkinson disease, type I neurodegeneration with brain iron accumulation, and other disorders. Despite years of investigation, the reason for iron imbalance in the brain is not known. It also is not known whether the accumulation of iron in the brain is primary or secondary to development of neurodegenerative disorders. This review summarizes the present knowledge on the role of iron in human brain disorders.
Assuntos
Encefalopatias/etiologia , Ferro/fisiologia , Animais , Humanos , Deficiências de FerroAssuntos
Epilepsia/genética , Haptoglobinas/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , FenótipoRESUMO
Green tea polyphenols like epigallocatechin gallate (EGCG) have been proposed as a cancer chemopreventative. Several studies have shown that EGCG can act as an antioxidant by trapping proxyl radicals and inhibiting lipid peroxidation. The main propose of this study is to investigate the antioxidant capacity of EGCG using erythrocyte membrane-bound ATPases as a model. The effects of EGCG on t-butylhydroperoxide-induced lipid peroxidation and the activity of membrane-bound ATPases in human erythrocyte membranes were studied. The extent of oxidative damage in membranes was assessed by measuring lipid peroxidation, (TBARS, thiobarbituric acid reactive substances formation) and the activity of ATPases (Na(+)/K(+), Ca(2+), and CaM-activated Ca(2+) pump ATPases). EGCG blocked t-BHP induced lipid peroxidation in erythrocyte membranes, significantly (0.45 +/- 0.02 vs 0.20 +/- 0.01; t-BHP vs t-BHP + EGCG respectively, microm/L TBARS) (p < 0.05). EGCG also protected ATPases against t-BHP induced damage; for Na/K ATPase (2.4 +/- 0.2 vs 1.6 +/- 0.1 vs 2.44 +/- 0.2, nmol Pi/min/mg protein, control vs t-BHP vs t-BHP and EGCG respectively), for Ca ATPase (5.8 +/- 0.4 vs 3.9 +/- 0.3 vs 5.6 +/- 0.34, nmol Pi/min/mg protein, control vs t-BHP vs t-BHP and EGCG respectively) and for CaM-Ca ATPase (14.7 +/- 0.7 vs 7.3 +/- 0.4 vs 11.6 +/- 0.55, nmol Pi/min/mg protein, control vs t-BHP vs t-BHP and EGCG respectively) (p < 0.05). In conclusion our results indicate that EGCG is a powerful antioxidant that is capable protecting erythrocyte membrane-bound ATPases against oxidative stress.