RESUMO
Having a large clinical material at their disposal, the authors base the necessity of the search and administration of more effective methods of duodenal ulcer treatment. Analyze the therapeutic effect produced by the enkephalin analogs (dalargin and its combinations with trichopol, de-nol, oxacillin) in connection with infection with Campylobacter . Comparison of the clinico-endoscopic data with the histological and cytological findings enabled arriving at a conclusion about the pathogenetic effect of the antimicrobial drugs. As a rule, the healing of ulcerous defects set in on days 11-14 of the treatment.
Assuntos
Antiácidos/uso terapêutico , Úlcera Duodenal/tratamento farmacológico , Adolescente , Hidróxido de Alumínio/uso terapêutico , Benzocaína/uso terapêutico , Criança , Combinação de Medicamentos , Leucina Encefalina-2-Alanina/análogos & derivados , Leucina Encefalina-2-Alanina/uso terapêutico , Feminino , Humanos , Hidróxido de Magnésio/uso terapêutico , Masculino , Compostos Organometálicos/uso terapêutico , Cicatrização/efeitos dos fármacosRESUMO
Thirty-six children with duodenal ulcer were examined for the coagulation and thrombocytic components of hemostasis. Use was made of the new coagulologic research methods based on administration of the synthetic tri- and tetrapeptides containing a chromoform group. The high sensitivity of the synthetic peptides enables the use of plasma in high dilutions, owing to which the effect of inhibitors is decreased and a small amount of blood is only required, being of paramount importance in carrying out serial tests. In acute ulcer 1/3 of the children show the signs of the DIC syndrome compensated at the expense of the high content of anticoagulants. At the same time 4 patients were discovered to have coagulologic disorders characteristic of Willebrand's disease (3 cases) and thrombasthenia (1 case). The coagulologic alterations should be taken into consideration in treatment administration, since the compensated DIC syndrome untreated by anticoagulant therapy aggravates the course of the ulcerous process and gives rise to hemorrhagic diathesis. Meanwhile in children with hemorrhagic diathesis, peptic ulcer may cause severe, life-threatening hemorrhages.
