RESUMO
Distal arterial occlusion in the hand threatens the viability of the digits and is difficult to treat. This study reports two cases in which fibrinolytic agents were used successfully to restore circulation in the digital arteries.
Assuntos
Dedos/irrigação sanguínea , Isquemia/tratamento farmacológico , Terapia Trombolítica , Doença Aguda , Adulto , Angiografia , Feminino , Fibrinolíticos/uso terapêutico , Humanos , Isquemia/etiologia , Ativador de Plasminogênio Tipo Uroquinase/uso terapêuticoRESUMO
In a previous study we were able to show that in women over the age of 45 the level of 1,25-dihydroxyvitamin D (1,25(OH)2D) in bone, but not in serum, is significantly reduced when compared with younger women. In the present study we measured the concentration of 1,25(OH)2D in sera and bones of 19 female patients with subcapital fractures of the femur, mean age 78 +/- 2 years. We were able to show that serum levels of 1,25(OH)2D were within the normal range, while bone levels were markedly reduced compared to levels in femoral bone obtained from young female cadavers or to the previously reported levels in non-osteoporotic elderly women. Thus, reduced levels of 1,25(OH)2D in bones of elderly women may lead, together with other factors, to subcapital fractures.
Assuntos
Colo do Fêmur/química , Vitamina D/análise , Adulto , Idoso , Análise Química do Sangue , Cadáver , Cálcio/metabolismo , Feminino , Fraturas do Colo Femoral/etiologia , Humanos , Osteoporose/complicaçõesRESUMO
The most active metabolite of vitamin D is 1,25-dihydroxyvitamin D [1,25(OH)2D]. Its level in the bone may play a role in the pathogenesis of metabolic bone diseases such as osteoporosis. To assess this, and to see whether there is correlation between serum and bone levels, we studied serum and bone samples taken from 43 patients (18 men and 25 women) undergoing different orthopedic procedures. Patients were studied according to sex and age groups (less than 45 years, 46-60 years, greater than 61 years). Serum level of 1,25(OH)2D was found to be 29.7 +/- 2.61 pg/ml (mean +/- SEM) for women, 32.2 +/- 3.86 pg/ml for men, and 30.7 +/- 2.18 pg/ml for the group as a whole. No significant statistical differences were found among age subgroups in either sex or between sexes. Bone level of 1,25(OH)2D was found to be 31.5 +/- 4.46 pg/g for women, 26.5 +/- 3.06 pg/g for men, and 29.4 +/- 2.81 pg/g for the entire group. No significant statistical difference was found between the age subgroups for men. However, the level of 1,25(OH)2D was found to be higher in the group of younger women (less than 45 years) compared with the older women (46-60 years and greater than 61 years) (P less than 0.005).
Assuntos
Envelhecimento/metabolismo , Osso e Ossos/química , Calcitriol/análise , Adolescente , Adulto , Idoso , Osso e Ossos/metabolismo , Calcitriol/sangue , Calcitriol/metabolismo , Cromatografia Líquida de Alta Pressão , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Nine anatomical parameters that may have a relation to the spinal canal size were directly measured in each of 594 cervical and lumbar vertebrae from young adult cadaver skeletons. The anteroposterior diameter of the spinal canal was the only parameter which could be statistically correlated with its cross-sectional area (P less than 0.05), and hence justifies the accepted practice of its use as an indicator of bony spinal canal size.
