Association of Amniotic Fluid Volume and Fetal Cardiac and Cerebrovascular Parameters in Fetal Growth Restriction.

OBJECTIVES: To investigate the prevalence of oligohydramnios, brain sparing, and cardiac dysfunction among a cohort of fetal growth restriction (FGR). METHODS: To assess the prevalence of oligohydramnios amongst a large sample of FGR fetuses, we screened a database of ultrasounds of FGR pregnancies from our maternal-fetal medicine clinics (clinical cohort) for diminished amniotic fluid volume. Using a threshold of a maximum vertical pocket (MVP) of <2 cm for "oligohydramnios," and 2 to 3 cm as a "reduced fluid" group, trends of Doppler values and cardiac parameters were assessed from pregnancies in an ongoing research study (comprehensive cohort). RESULTS: In the clinical cohort, oligohydramnios was identified in only 2/229 (0.8%) and reduced fluid in 19/229 (8%). In the comprehensive cohort, oligohydramnios was seen in 3/126 (2.3%) and reduced fluid in 14/126 (11.1%). A high rate of cardiac and Doppler abnormalities were observed in the oligohydramnios group of the comprehensive cohort. The patients with oligohydramnios had a distinctly different cardiac phenotype with small (2/3 with cardiac area <5th%) (P = 0.01) and round (3/3 with global sphericity index <5th%) (P = 0.02) hearts. CONCLUSION: Oligohydramnios, when present with FGR, is accompanied by high rates of cerebral and cardiovascular abnormalities.

Validating tablet perimetry against standard Humphrey Visual Field Analyzer for glaucoma screening in Indian population.

Purpose: The aim of this study was to determine the correlation between the perimetric outcomes using a free application program of the iPad, 'Visual Fields Easy' (VFE), and Humphrey Visual Field Analyzer (HVFA), in normal as well as eyes with glaucomatous damage of varying severity. Methods: In this prospective, cross-sectional, observational pilot investigation, visual field testing was carried out in 210 eyes of 210 patients (60 Normal, 150 Glaucoma), using suprathreshold VFE application (Version 8) on the iPad and Standard White-on-White using HVFA. Severity of glaucoma was categorized using Hodapp-Anderson-Parrish criteria for visual field defects. The results of the VFE program were compared to the 24-2 SITA FAST HVFA. Results: Data of 210 patients, 100 (47.6%) females, and 110 (52.4%) males, age ranging from 42 to 78 years, Mean 56.64 ± 10.67 years, was analyzed. The Spearman correlation coefficient showed a significant inverse relationship between missed points on the VFE app with MD (S = -0.783) and a parabolic relationship with PSD (S = 0.646) values obtained with the HVFA. As regards missed points, for mild glaucoma, missed points were 37.5, sensitivity was 77.8% and specificity was 52.6%; for moderate glaucoma, missed points were 33.5, sensitivity was 90% and specificity was 48% while for severe glaucoma, missed points were 23, sensitivity was 97% and specificity was 70%. AROC for eyes with mild glaucoma versus normal was 0.419 (95% CI: 0.343-0.495), moderate glaucoma versus normal was 0.705 (95% CI: 0.630-0.780) and severe glaucoma versus normal was 0.857 (95% CI: 0.806-0.908). Conclusion: Suprathreshold perimetry using VFE is not suitable as a rapid screening tool for mass screening of glaucoma. VFE cannot be used as a substitute for HVFA in clinic because of its inability to detect early or moderate glaucoma.