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1.
Ars pharm ; 53(2): 21-27[2], abr.-jun. 2012. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-99374

RESUMO

Aim: The objective behind this study is to improve the compressibility, flowability, packability and dissolution rate of aceclofenac by preparing spherical crystals using quasi emulsion solvent diffusion method. Materials and Method: Spherical agglomerates of aceclofenac were effectively prepared using acetone, dichloromethane and 0.1 N HCl as good solvent, bridging liquid and poor solvent respectively with different concentrations of polyethylene glycol 6000 in poor solvent. Results: Prepared agglomerates were spherical with enhanced fragmentation and less elastic recovery. Particle size, flowability, compactibility, packability, solubility and dissolution rate of agglomerates were preferably improved for direct compression compared with raw crystal of aceclofenac. X-ray powder diffraction and differential scanning calorimetry study indicated slight amorphization of drug during recrystallization but not associated with any chemical transition indicated by Fourier transforms infrared spectra. Conclusion: The present research improved tableting properties and dissolution characteristics of aceclofenac(AU)


Objetivo: El objetivo detrás de este estudio es mejorar la tasa de compresión, la fluidez, packability y la disolución de aceclofenaco mediante la preparación de cristales esféricos utilizando el método cuasi emulsión de disolvente de difusión. Material y Método: Aglomerados esféricos de aceclofenac se prepararon con acetona, diclorometano y ac. HCl 0,1 N que actúan como buen disolvente, líquido aglutinante y mal disolvente respectivamente. En este último caso se añadieron diferentes cantidades de propilenglicol 6000. Resultados: Los aglomerados esféricos obtenidos se caracterizaron por tener una mayor fragmentación y menor recuperación elástica. En comparación con los cristales originales de aceclofenac, los aglomerados tienen mejores características de tamaño de partícula, fluidez, compactabilidad, empaquetado, solubilidad y velocidad de disolución lo que les hace más adecuados para compresión. Los estudios de difracción por rayos X y calorimetría diferencial de barrido mostraron una pequeña tendencia a formar amorfos durante la recristalización del aceclofenac aunque el estudio mediante espectroscopía infrarroja de Fournier no mostró cambios químicos. Conclusión: La presente investigación mejora de las propiedades de tabletas y characteristics de disolución de aceclofenaco(AU)


Assuntos
Humanos , Cristalização/métodos , Polietilenoglicóis/farmacologia , Anti-Inflamatórios/farmacologia , Composição de Medicamentos/métodos
2.
J Stem Cells Regen Med ; 1(1): 8-24, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-24692857

RESUMO

Tissue engineering is a rapidly expanding field, which applies the principles and methods of physical sciences, life sciences and engineering to understand physiological and pathological systems and to modify and create cells and tissues for therapeutic applications. It has emerged as a rapidly expanding 'interdisciplinary field' that is a significant potential alternative wherein tissue and organ failure is addressed by implanting natural, synthetic, or semi synthetic tissue or organ mimics that grow into the required functionality or that are fully functional from the start. This review presents in a comprehensive manner the various considerations for the reconstruction of various tissues and organs as well as the various applications of this young emerging field in different disciplines.

3.
J Colloid Interface Sci ; 206(2): 361-368, 1998 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-9756648

RESUMO

pH- and temperature-sensitive hydrogel nanoparticles of copolymers of vinylpyrrolidone (VP) and acrylic acid (AA) cross-linked with NN' methylene bis acrylamide (MBA) of sizes up to 50 nm diameter loaded with marker compound FITC-dextran (mol wt. 19.3 kD) were prepared in the aqueous core of reverse micellar droplets and were dispersed in aqueous buffer. These particles have high entrapment efficiency, and the lyophilized powder can be redissolved in buffer without any significant agglomeration. The release of FITC-dextran from these particles was found to be pH- and temperature-dependent. The release was slow in acid solution, but it increased considerably as the pH of the medium was increased. The release rate was also increased with the increase of temperature. Copyright 1998 Academic Press.

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