1.
Chem Commun (Camb)
; 58(61): 8564-8567, 2022 Jul 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35815846
RESUMO
Herein, an enantioselective total synthesis of (-)-panduratin D, a novel secondary metabolite against human pancreatic PANC-1 cancer cell, from commercially available 3-methoxyphenol is reported. The synthesis was completed in nine steps and the key features include Sonogashira coupling, anionic Snieckus-Fries rearrangement, directed ortho metalation, tandem Si â C Alkyl rearrangement/Claisen-Schmidt condensation, and chiral boron complex-promoted asymmetric Diels-Alder cycloaddition. These endeavors could facilitate the biological studies of (-)-panduratin D and its analogs.