RESUMO
The authors demonstrate that severe and fulminant forms of acute hepatitis B (AHB) are associated with low concentrations of HBsAg and anti HBs in peripheral blood. In the majority of cyclic AHB cases HBeAg is registered in the serum for 2-3 weeks, whereas in more severe course of AHB its indication is shorter, with occasional occurrence of serological window. The more severe and longer was AHB course the lower was concentration of HBsAg in peripheral blood. The assessment of the complete profile of serological markers of HBV infection and HBsAg concentration in the serum in the course of the disease will promote more effective diagnosis of the disease pattern and outcome.
Assuntos
Anticorpos Anti-Hepatite B/sangue , Antígenos de Superfície da Hepatite B/sangue , Vírus da Hepatite B/imunologia , Hepatite B/imunologia , Doença Aguda , Adolescente , Adulto , Biomarcadores/sangue , Hepatite B/virologia , Humanos , Pessoa de Meia-Idade , PrognósticoAssuntos
Desoxirribonucleases/uso terapêutico , Hepatite B/tratamento farmacológico , Extratos Pancreáticos/uso terapêutico , Doença Aguda , Adulto , Animais , Antivirais , Bovinos , Desoxirribonucleases/administração & dosagem , Feminino , Humanos , Infusões Intravenosas , Masculino , Extratos Pancreáticos/administração & dosagemRESUMO
Different patterns of serum HBV markers (HBsAg, HBsAb, HBeAg, HBeAb, HBcAb) were identified in 82 patients (12 with chronic active hepatitis, 67 with hepato-cirrhosis developing in the outcome of chronic active hepatitis, and in 3 with primary biliary cirrhosis) of 105 (78%) patients with chronic liver diseases. Besides, IgM HBcAb were identified in 9 of 47 patients (19.1%), HBsAg IgM in 4 of 9 patients (44.4%), antibodies to the delta-agent in 8 of 23 (34.8%) suffering from chronic liver diseases with the presence of serum HBV markers. Chronic liver diseases with the presence of HBsAg and/or other serum HBV markers were characterized by a variety of clinico-laboratory manifestations determined by the involvement of some organs and systems in a process. A degree of activity of chronic liver diseases was not correlated with a replication phase, an integration phase, and an immunological resolution phase in 49 patients with identified phases of development of HBV-infection. More frequent identification of serum HBV markers including those of a replication phase was not noticed among patients on prolonged immunosuppressant therapy.
Assuntos
Anticorpos Anti-Hepatite B/análise , Antígenos da Hepatite B/análise , Hepatopatias/imunologia , Adolescente , Adulto , Idoso , Biomarcadores/análise , Doença Crônica , Feminino , Hepatite Crônica/imunologia , Humanos , Imunoglobulina M/análise , Cirrose Hepática/imunologia , Cirrose Hepática Biliar/imunologia , Masculino , Pessoa de Meia-IdadeAssuntos
Diabetes Mellitus Tipo 1/complicações , Hepatite B/complicações , Adolescente , Criança , Pré-Escolar , Feminino , Hepatite B/diagnóstico , Anticorpos Anti-Hepatite B/análise , Antígenos da Hepatite B/análise , Antígenos da Hepatite B/imunologia , Vírus da Hepatite B/imunologia , Humanos , MasculinoRESUMO
Carcinoembryonic antigen was studied in 241 controls--patients with different diseases, 121 cases of intestinal polyp, 69 cases of large bowel carcinoma, 28 cases of stomach cancer and 65 patients with malignancies at other sites (total-524). Significantly high levels were found in large bowel and stomach cancer as well as cases of extensive tumor growth, relapse or metastases.