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Nutr Res ; 29(5): 298-304, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-19555810

RESUMO

Flavocoxid (Limbrel), a proprietary mixture of flavonoid molecules (baicalin and catechin), was tested against a traditional nonsteroidal anti-inflammatory drug, naproxen, for the management of the signs and symptoms of moderate osteoarthritis (OA) in humans. Discomfort and global disease activity were used as the primary end points, and safety assessments were also taken for both treatments as a secondary endpoint. In this double-blind study, 103 subjects were randomly assigned to receive either flavocoxid [500 mg twice daily (BID)] or naproxen (500 mg BID) in a 1-month onset of action trial. Outcome measures included the short Western Ontario and McMaster University Osteoarthritis Index, subject Visual Analogue Scale for discomfort and global response, and investigator Visual Analogue Scale for global response and fecal occult blood. Both flavocoxid and naproxen showed significant reduction in the signs and symptoms of knee OA (P < or = .001). There were no statistically detectable differences between the flavocoxid and naproxen groups with respect to any of the outcome variables. Similarly, there were no statistically detectable differences between the groups with respect to any adverse event, although there was a trend toward a higher incidence of edema and nonspecific musculoskeletal discomfort in the naproxen group. In this short-term pilot study, flavocoxid was as effective as naproxen in controlling the signs and symptoms of OA of the knee and would present a safe and effective option for those individuals on traditional nonsteroidal anti-inflammatory drugs or cyclooxygenase-2 inhibitors. A low incidence of adverse events was reported for both groups.


Assuntos
Catequina/uso terapêutico , Flavonoides/uso terapêutico , Articulação do Joelho/efeitos dos fármacos , Naproxeno/uso terapêutico , Osteoartrite do Joelho/tratamento farmacológico , Dor/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Adulto , Idoso , Anti-Inflamatórios não Esteroides/uso terapêutico , Catequina/efeitos adversos , Catequina/farmacologia , Método Duplo-Cego , Combinação de Medicamentos , Feminino , Flavonoides/efeitos adversos , Flavonoides/farmacologia , Humanos , Masculino , Pessoa de Meia-Idade , Naproxeno/efeitos adversos , Medição da Dor , Fitoterapia , Projetos Piloto , Extratos Vegetais/farmacologia , Scutellaria
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