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2.
Osteoporos Int ; 22(6): 2011-5, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21523398

RESUMO

Distraction osteogenesis (DO) is a surgical technique widely used in orthopedic surgery for the treatment of various pathological conditions such as leg length discrepancy, bone deformity or bone defects. The basic principle of the callotasis technique includes performing a transverse bone section before gradually distracting the two bone segments. New bone tissue is generated in the gap between the two segments. Bone regeneration during DO is believed to occur in response to the longitudinal mechanical strain applied to the callus during healing. One of the limitations of this technique is the long period of time required for the newly formed bone tissue to mineralize and consolidate. Various studies have reported that among growth factors, bone morphogenetic proteins (BMPs) may play a central role in the molecular signaling cascade leading to bone renegeration and remodeling in a DO procedure. Ongoing research is aimed at developing methods to accelerate bone consolidation in order to reduce the time required to obtain consolidation. One of these methods is to test the ability of exogenous BMPs to increase bone regeneration and accelerate bone consolidation.


Assuntos
Osteogênese por Distração/métodos , Proteínas Morfogenéticas Ósseas/farmacologia , Regeneração Óssea/efeitos dos fármacos , Regeneração Óssea/fisiologia , Calo Ósseo/fisiologia , Humanos , Técnica de Ilizarov , Estresse Mecânico
3.
Orthop Traumatol Surg Res ; 96(8): 884-9, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21075698

RESUMO

INTRODUCTION: Extra-abdominal desmoid fibromatosis (EADF) is a benign tumoral condition, classically managed by more or less radical and sometimes mutilating excision. This treatment strategy is associated with a recurrence rate of nearly 50% according to various reports. HYPOTHESIS: EADF may show spontaneous stabilization over time. METHODS: A retrospective series of 26 cases of EADF managed by simple observation was studied to assess spontaneous favorable evolution and identify possible factors impacting evolution. Eleven cases were of primary EADF with no treatment or surgery, and 15 of recurrence after surgery with no adjuvant treatment. MRI was the reference examination during follow-up. RESULTS: Twenty-four cases showed stabilization at a median 14 months; there were no cases of renewed evolution after stabilization. One primary tumor showed spontaneous regression, and one recurrence still showed evolution at end of follow-up (23 months). The sole factor impacting potential for evolution was prior surgery. No radiologic or pathologic criteria of evolution emerged from analysis. DISCUSSION: The present series, one of the largest dedicated to EADF managed by observation, confirmed recent literature findings: a conservative "wait-and-see" attitude is reasonable and should be considered when large-scale resection would entail significant functional or esthetic impairment. LEVEL OF EVIDENCE: Level IV, retrospective study.


Assuntos
Fibroma/terapia , Fibromatose Agressiva/terapia , Recidiva Local de Neoplasia/terapia , Neoplasias de Tecidos Moles/terapia , Adolescente , Adulto , Idoso , Progressão da Doença , Feminino , Fibroma/diagnóstico , Fibroma/mortalidade , Fibromatose Agressiva/diagnóstico , Fibromatose Agressiva/mortalidade , Humanos , Estimativa de Kaplan-Meier , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/diagnóstico , Recidiva Local de Neoplasia/mortalidade , Observação , Estudos Retrospectivos , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/mortalidade , Adulto Jovem
4.
Orthop Traumatol Surg Res ; 95(6): 431-6, 2009 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19740715

RESUMO

INTRODUCTION: Congenital longitudinal deficiency of the tibia is a rare and often syndromic anomaly. Amputation is usually the preferred treatment option in complete absence of the tibia; however, a conservative management might be implemented in partial forms or in case of amputation refusal. Our experience with the Ilizarov fixator, convinced us this device was the best suited for progressive correction of lower limbs length discrepancies and articular or bone angular limb deformities (ALD). The aim of this study is to highlight the interest of the Ilizarov fixator in the multistage conservative treatment of congenital tibial deficiencies. MATERIAL AND METHODS: A retrospective study was conducted in nine patients suffering from Type I or II congenital tibial deficiencies (Jones) and sequentially managed using the Ilizarov technique. The functional outcome after treatment completion was then clinically assessed. RESULTS: The different stages of correction were recorded for each individual patient. Patients were assessed at a mean follow-up of 18,3 years (4-32 years). The mean maximum knee flexion was 35 degrees (0 degrees -90 degrees ) in type I deficiencies and 118 degrees (90 degrees -140 degrees ) in type II deficiencies. One patient underwent amputation and a bilateral knee arthrodesis was performed in another case. DISCUSSION: Few series in the literature report a comparable length of follow-up period in the conservative management of severe congenital tibial deficiencies. In our study, the Ilizarov fixator provided satisfactory progressive corrections of severe congenital tibial deficiencies. LEVEL OF EVIDENCE: Level IV therapeutic retrospective study.


Assuntos
Técnica de Ilizarov , Deformidades Congênitas das Extremidades Inferiores/cirurgia , Tíbia/anormalidades , Tíbia/cirurgia , Pré-Escolar , Seguimentos , Humanos , Lactente , Deformidades Congênitas das Extremidades Inferiores/classificação , Deformidades Congênitas das Extremidades Inferiores/reabilitação , Recuperação de Função Fisiológica , Estudos Retrospectivos
6.
Rev Stomatol Chir Maxillofac ; 106(6): 349-51, 2005 Dec.
Artigo em Francês | MEDLINE | ID: mdl-16344756

RESUMO

INTRODUCTION: We report a case of donor site morbidity late after harvesting a free fibular flap for reconstruction of the mandibular symphsis. CASE REPORT: An 8-year-old boy presented a valgus deformity of the ankle 4 years harvesting of a vascularized fibular graft for mandibular reconstruction. The deformation was repaired with a tibial bone slit and pin fixation. The biomechanical result was very satisfactory, allowing normal gait. DISCUSSION: We recall the rules for fibular flap harvesting needed to prevent deformation of the donor site in children aged less than 9 years.


Assuntos
Mandíbula/cirurgia , Procedimentos de Cirurgia Plástica/efeitos adversos , Retalhos Cirúrgicos , Ossos do Tarso/lesões , Coleta de Tecidos e Órgãos/efeitos adversos , Transplante Ósseo , Criança , Fíbula/transplante , Humanos , Traumatismos da Perna/cirurgia , Masculino , Neoplasias Mandibulares/cirurgia , Procedimentos Cirúrgicos Bucais/efeitos adversos , Ossos do Tarso/cirurgia
7.
Rev Stomatol Chir Maxillofac ; 106(6): 352-5, 2005 Dec.
Artigo em Francês | MEDLINE | ID: mdl-16344757

RESUMO

BACKGROUND: Mandibular reconstruction with fibula free flap is a challenge in pediatric patients because of the size of the bone and absence of growth without epiphyseal transplantation. CASE REPORT: We report 2 cases of free fibula flap in children for mandibular reconstruction. The 2 patients presented with growth insufficiency of the bone graft after few years of evolution. DISCUSSION: Growth insufficiency was treated with different surgical procedures which were discussed We review the consequences on growth after fibula free flap and the specific indications to achieve epiphyseal fibular growth in children.


Assuntos
Doenças do Desenvolvimento Ósseo/etiologia , Transplante Ósseo/fisiologia , Fíbula/transplante , Mandíbula/cirurgia , Procedimentos de Cirurgia Plástica/efeitos adversos , Retalhos Cirúrgicos/fisiologia , Doenças do Desenvolvimento Ósseo/cirurgia , Pré-Escolar , Feminino , Fíbula/crescimento & desenvolvimento , Humanos , Lactente , Masculino , Neoplasias Mandibulares/cirurgia , Micrognatismo/etiologia , Micrognatismo/cirurgia , Procedimentos Cirúrgicos Bucais/efeitos adversos , Osteogênese por Distração
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