[Attitudes towards screening and prevention of breast and ovarian cancers with hereditary predisposition. Survey by female gynecologists in the north of France]. / Attitudes envers le dépistage et la prévention des cancers mammaires et ovariens avec prédisposition héréditaire. Enquête auprès des femmes gynécologues de la région Nord de la France.

Search for mutations of BRCA1 in women at hereditary risk for cancer is now possible. We asked the female gynaecologists of our county (north of France) their opinion about the search of a mutation of BRCA1 if they had a familial risk of breast cancer. Our aim was to obtain the opinion of informed women about their willingness to do the test for themselves and about the consequences they should accept. One hundred and eighty-three women received a questionnaire by post. The response rate was 56.3%. Twenty-four percent of the responders had a first degree relative with breast cancer. Most of the responders (87.4%; IC 95%: 81-93.8) would ask for the search of a mutation of BRCA1. The percentage of women who would accept the test is smaller for the women who have a first degree relative with breast cancer (72.0% vs 92.3%; P = 0.02). The reasons given to do the test were a better screening or prevention (69.7%) and the knowledge of a personal risk (49.4%). For breast cancer, 93.2% (95% CI: 88.4-98) would accept a screening protocol, 30.1% (CI: 21.3-38.9) would accept a prophylactic bilateral mastectomy. For ovarian cancer, 93.2% (CI: 88.4-98) would accept the screening, 52.4% (CI: 42.8-62) would accept a prophylactic ovariectomy. In conclusion, most of the informed women would ask for the test and the surgical options for reducing the risk of cancer are not absolutely rejected. Of course, only future studies will state precisely the choice of truly implicated women.

[Efficacy of oral contraceptives on acne. Apropos of a comparative study of Varnoline vs Diane in 69 women with acne]. / Efficacité sur l'acné des contraceptifs oraux. A propos d'une étude comparative Varnoline versus Diane chez 69 femmes acnéiques.

The authors conducted a comparative study of the effect of two oral contraceptives Varnoline and Diane in the treatment of androgenic manifestations: acne and hirsutism. The two products tested seem to have a similar efficacy on this type of clinical manifestations.

[Homologous artificial insemination and male infertility. Study of prognostic factors]. / Inséminations artificielles homologues et infertilité masculine. Recherche de facteurs de pronostic.

Artificial insemination using the husband's semen (AIH) can help overcome a number of cases of sterility, particularly where these are male in origin. But the results are not always in proportion to the effort required, both from the patients and their doctor. We have compared 25 cases in which AIH resulted in pregnancy with 25 cases in which no pregnancy was achieved after a minimum of 6 cycles' insemination. No factor other than success or failure entered into the selection of cases for comparison. No significant difference was observed in age, past medical history, clinical findings and treatment used. However, study of the seminal analyses showed that the number of spermatozoa was only a secondary factor; sperm motility, and its duration, were more important. This gave two graphs defining two prognostic zones. In 72% of cases, pregnancy was achieved during the first 5 cycles of insemination using AIH. Lastly, miscarriages increased in frequency with age. The number of cases studied is obviously too few to provide any binding statistical conclusions, but these preliminary results give grounds for continuing the study; mathematical models ought to make it possible to identify prognostic factors.