Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 10 de 10
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
5.
J Dermatol ; 43(12): 1429-1432, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27450766

RESUMO

Hereditary lactate dehydrogenase (LDH) M-subunit deficiency is very rare and we have found reports of close to a dozen cases in the published work, two of which were associated with pustular psoriasis-like lesions. We report a third case of pustular psoriasis-like eruptions associated with LDH M-subunit deficiency, which occurred 24 years after the diagnosis of LDH M-subunit deficiency. These cases indicate that abnormal activity of LDH can induce pustular psoriatic lesions in the long term. Some patients with symptoms of hereditary LDH M-subunit deficiency have antecedent annular scaly plaque lesions, that resemble psoriatic lesions. We discuss a hypothesis to explain this scenario.


Assuntos
L-Lactato Desidrogenase/deficiência , L-Lactato Desidrogenase/genética , Psoríase/genética , Doenças Raras/genética , Deleção de Sequência , Adulto , Sequência de Aminoácidos/genética , Biópsia , Éxons/genética , Feminino , Glucocorticoides/uso terapêutico , Humanos , Imuno-Histoquímica , Isoenzimas/deficiência , Isoenzimas/genética , Lactato Desidrogenase 5 , Prednisolona/uso terapêutico , Psoríase/tratamento farmacológico , RNA Mensageiro/genética , Análise de Sequência de DNA , Análise de Sequência de RNA , Pele/patologia , Fatores de Tempo , Valina/genética
8.
J Dermatol ; 43(9): 1071-4, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26992088

RESUMO

Pemetrexed, which is used for the treatment of non-small cell lung carcinoma and malignant mesothelioma, induces cutaneous adverse reactions in approximately 20% of patients. There are also reports of the induction of fibrosing disorders. We describe a case of pemetrexed-induced scleroderma-like conditions in the lower legs of a patient whose pulmonary carcinoma has been relatively well controlled, with prolongation of the dose interval, in spite of the discomfort in both his legs. Skin biopsy revealed dermal fibrosis and dilated lymph vessels in the dermis, but lymphocytic infiltration around the lymph vessels, in contrast to the blood vessels, was minimal. Immunohistochemical staining revealed that the major subsets of T cells that had infiltrated around blood vessels were CD3 and CD45Ro, but no B cells were detected. High serum levels of interleukin (IL)-4 and IL-6 suggested that T cells, which secrete these cytokines, may be involved in the pathogenesis of this condition. Magnetic resonance imaging of the lower extremities revealed muscular and fascial involvement. Several chemotherapeutic agents, such as taxanes, gemcitabine and bleomycin, are known to induce scleroderma-like changes, and we should also keep the side-effects of pemetrexed in mind when we encounter patients with fibrosing conditions.


Assuntos
Antineoplásicos/efeitos adversos , Neoplasias Encefálicas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/terapia , Neoplasias Pulmonares/terapia , Pemetrexede/efeitos adversos , Esclerodermia Localizada/induzido quimicamente , Antineoplásicos/administração & dosagem , Antineoplásicos/uso terapêutico , Biópsia , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/secundário , Carcinoma Pulmonar de Células não Pequenas/genética , Carcinoma Pulmonar de Células não Pequenas/patologia , Carcinoma Pulmonar de Células não Pequenas/cirurgia , Quimiorradioterapia , Cisplatino/uso terapêutico , Quimioterapia de Consolidação , Derme/patologia , Fibrose , Humanos , Quimioterapia de Indução , Interleucina-4/metabolismo , Interleucina-6/metabolismo , Perna (Membro) , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Pemetrexede/administração & dosagem , Pemetrexede/uso terapêutico , Tomografia por Emissão de Pósitrons , Radiossensibilizantes/uso terapêutico , Esclerodermia Localizada/sangue , Esclerodermia Localizada/diagnóstico , Linfócitos T/metabolismo , Tomografia Computadorizada por Raios X , Vimblastina/análogos & derivados , Vimblastina/uso terapêutico , Vinorelbina
9.
J Dermatol ; 43(8): 947-50, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26892480

RESUMO

Pigmented cosmetic dermatitis-like (Riehl's melanosis-like) pigmentation was reported in three of 27 patients with primary Sjögren's syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjögren's syndrome or anti-SSA antibody and possible associations with specific types of human leukocyte antigen (HLA) and infiltrating lymphocytes. These middle-aged Japanese women had reticular facial pigmentation and histopathological examination revealed interface dermatitis, melanophages, and dense lymphocytic infiltration around hair follicles and sweat ducts. HLA typing revealed common antigenic equivalents or genetic typing of HLA-A2, DR52, DPA1(02:02) and DPB1(05:01). Immunohistochemical staining revealed major subsets of T cells to be CD8 and CD45RO. Some Foxp3- and few IL17-positive cells were found in strong contrast to the major CD4 subset of infiltrated T cells in annular erythema associated with Sjögren's syndrome. Apparently, our patients' pigmentation represented a specific etiology associated with primary Sjögren's syndrome or anti-SSA antibody.


Assuntos
Anticorpos Antinucleares/sangue , Dermatite/imunologia , Dermatite/patologia , Síndrome de Sjogren/patologia , Idoso , Dermatite/etiologia , Feminino , Teste de Histocompatibilidade , Humanos , Pessoa de Meia-Idade , Transtornos da Pigmentação/etiologia , Transtornos da Pigmentação/imunologia , Transtornos da Pigmentação/patologia , Síndrome de Sjogren/complicações , Síndrome de Sjogren/imunologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...