1.
Farmaco Sci
; 35(8): 691-7, 1980 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7450053
RESUMO
Clozapine, a neuroleptic drug isostere of the phenothiazines, at a dose of 10(-3) M decreased the oxygen consumption of rat brain slices and homogenates. However, this effect was not potentiated when brain slices were incubated with 100 mM potassium or in a calcium-free medium, the uncoupling of brain mitochondrial oxidative phosphorylation by 10(-3) M clozapine can also be rulled out.
Assuntos
Encéfalo/efeitos dos fármacos , Clozapina/farmacologia , Dibenzazepinas/farmacologia , Glucose/metabolismo , Fosforilação Oxidativa/efeitos dos fármacos , Consumo de Oxigênio/efeitos dos fármacos , Animais , Encéfalo/metabolismo , Encéfalo/ultraestrutura , Técnicas In Vitro , Masculino , Mitocôndrias/metabolismo , Ratos
2.
Arch Farmacol Toxicol
; 5(3): 290-2, 1979 Dec.
Artigo
em Espanhol
| MEDLINE
| ID: mdl-546358
3.
Farmaco Sci
; 32(9): 672-7, 1977 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20331
RESUMO
Dibenzepin hydrochloride (10(-3) M) decreases the oxygen uptake of whole brain homogenates and uncouples brain mitochondrial oxidative phosphorylation. At the same concentration this drug inhibits oxygen uptake of rat brain slices when calcium is absent in the incubation or then contains an excess of potassium.