Investigation of neutron and gamma radiation protective characteristics of synthesized quinoline derivatives.

PURPOSE: Quinoline is formed by various natural compounds, such as alkaloids from the cinchona plant, which exhibit various biological activities, and is an important building material for the development of new drugs. Quinoline can be used in anti-radiation drug development but radiation interaction properties must be determined. MATERIAL AND METHODS: In this study, six types of synthesized quinoline derivatives were used. Fast neutron removal cross-section, mean free path, half value layer and transmission number were theoretically determined by using GEometry ANd Tracking 4 and FLUktuierende KAskade simulation codes for neutron shielding. Neutron dose absorption rates were determined using the 241Am-Be fast neutron source and the Canberra NP series portable BF3 gas proportional neutron detector. Gamma radiation shielding parameters were determined by using WinXCom and PSY-X/PSD software. Additionally, the genotoxic potentials of the derivatives were assessed by using the Ames/Salmonella bacterial reversion assay. RESULTS AND CONCLUSIONS: Neutron shielding parameters such as removal cross-section, mean free path, half value layer and transmission number were theoretically determined for fast neutrons. To determine neutron absorption capacity of quinoline derivatives, neutron absorption, experiments were conducted. In addition, gamma radiation shielding parameters were calculated such as the mean free path (MFP), mass attenuation coefficient (µt), half value thickness layer (HVL) and effective atomic number (Zeff) in the energy range of 0.015-15 MeV. The results of the all quinoline derivatives have excellent fast neutron shielding power compared to ordinary concrete. In addition, all quinoline derivatives have been found to have the capacity to attenuate gamma radiation. Moreover, they absorb well in both types of radiation, do not cause secondary radiation, and they are genotoxically safe at the tested concentrations. This study has demonstrated that these products can be used as active ingredients for a drug to be developed against radiation.

Simulation studies for gamma ray shielding properties of Halloysite nanotubes using MCNP-5 code.

Halloysite clay is a mineral found in natural and it has many applications in chemistry (for catalytic and extraction) and also in the medical field (for drugs delivery), so it is important to study the shielding properties of natural and modified nanotube Halloysite. The mass attenuation coefficient was simulated for natural Halloysite clay mineral and four others modified halloysite nanotubes using MCNP 5 code for incident gamma ray energies between 0.015 and 15 MeV. The mass attenuation coefficient was also calculated using the XCOM database for studied samples in the same energy range. The results obtained by the MCNP simulation were close to those obtained by XCOM calculation. Moreover, other shielding properties that described the interaction of incident gamma rays with Halloysite composites, such as the HVL, MFP, Zeff, and Neff were calculated using the simulated µm for gamma rays between 0.015 and 15 MeV.