RESUMO
This study was designed to evaluate any adverse effect of a hot water extract of black soybeans (Glycine max (L.) Merr.), when administered to both sexes of Crj:CD(SD)IGS rats at dietary levels of 0 (control), 0.5, 1.5 and 5.0% (6 rats/sex/group). During the study, the treatment had no adverse effects on clinical signs, survival, body weights, and food and water consumption, or on findings of ophthalmology, urinalysis, hematology, or blood biochemistry. Organ weights, gross pathology and histopathology exhibited no differences of toxicological significance between control and treated rats. Thus, the no-observed-adverse-effect level (NOAEL) of black soybean extract was concluded to be 5.0% (3,618 mg/kg body weight/day for males and 4,066 mg/kg body weight/day for females) from the present study.
Assuntos
Glycine max/química , Extratos Vegetais/toxicidade , Proteínas de Plantas/toxicidade , Administração Oral , Animais , Peso Corporal/efeitos dos fármacos , Testes de Química Clínica , Feminino , Testes Hematológicos , Longevidade/efeitos dos fármacos , Masculino , Nível de Efeito Adverso não Observado , Ratos , Ratos Sprague-Dawley , UrináliseRESUMO
The photodegradation of carotenoids by UVA irradiation in the presence of sulfides was investigated. The sulfides accelerated the photodegradation of carotenoids. A larger number of sulfur atoms of coexistent sulfides was more favorable to the acceleration effect of sulfides on the photodegradation of beta-carotene, but the alk(en)yl group of sulfides was less favorable to the acceleration effect of sulfur compounds. The acceleration effect depended on light intensity, temperature, and the initial concentrations of beta-carotene and sulfide.
