[Characteristics of the course of chronic liver diseases of hepatitis B etiology with delta infection in children]. / Osobennosti techeniia khronicheskikh zabolevanii pecheni HB-virusnoi étiologii s delta-infektsiei u detei.

Overall 120 children with chronic liver diseases of HB-virus etiology were examined. In 78.3% of the patients, RIA was used to reveal anti-delta in blood serum, 33 children were diagnosed to have chronic persistent hepatitis, 44 chronic active hepatitis, and 43 liver cirrhosis. The patients with anti-delta manifested certain characteristic features. There prevailed children from epidemiologically unfavourable regions as regards virus hepatitis B. There also prevailed boys. In one-third of the patients with chronic liver diseases and anti-delta, acute hepatitis ran a biphasic course. According to the data obtained, super-addition of delta-infection aggravates the disease; the process becomes chronic more rapidly, exacerbations are more pronounced. 16 out of 23 children showed delta-antigen in liver biopsy specimens; in patients with active disease, the antigen was detected in the nucleus and cytoplasm at a time. As the activity decreases, the antigen becomes mostly detectable in the cytoplasm.

[The role of congenital Enterovirus infection in the pathogenesis of suppurative and inflammatory diseases in newborn infants]. / Uchastie vrozhdennoi énterovirusnoi infektsii v patogeneze gnoino-vospalitel'nykh zabolevanii u novorozhdennykh.

Newborns with suppurative-inflammatory disease were found to be at high risk of intrauterine infection with Coxsackie enteroviruses from mothers with persistent enterovirus infection; in 54.9%, congenital Coxsackie virus infection was confirmed by virus antigen identification in the urine sediment cells and autopsy material. Coxsackie A viruses were identified in 68.7% of sepsis cases, 42.6% with local purulent infection foci, and in only 6.7% of practically healthy neonates. Specific features of the clinical course are analysed together with the pathohistological picture of congenital enterovirus infection associated with the vertical virus transmission from the mother having a persistent form of this infection. A suggestion is proposed that the severe course of suppurative-inflammatory conditions and the general character of neonatal bacterial infection are largely determined by the immunodeficient states which are etiologically related to congenital enterovirus infections.