RESUMO
The present study is focused on evaluating the antimutagenic properties of Schiff bases and Mn(III) complexes with L-Threonine, L-Serine and L-Tyrosine, which have antimicrobial activity. These six compounds were investigated for antimutagenic properties against Aflatoxin Bi (AFBi) by the micronucleus (MN) assay in a human lymphocyte cell culture in vitro. The protective role of these compounds against AFBi-induced MN is probably related to its doses. A mechanism has been proposed to reduce the effect of AFBi.
Assuntos
Aflatoxina B1 , Antibacterianos , Antídotos , Compostos Azo , Manganês , Serina , Tiossemicarbazonas , Treonina , Tirosina , Aflatoxina B1/antagonistas & inibidores , Aflatoxina B1/toxicidade , Antibacterianos/química , Antibacterianos/farmacologia , Antídotos/química , Antídotos/farmacologia , Compostos Azo/química , Compostos Azo/farmacologia , Bactérias/crescimento & desenvolvimento , Feminino , Humanos , Masculino , Manganês/química , Manganês/farmacologia , Serina/química , Serina/farmacologia , Tiossemicarbazonas/química , Tiossemicarbazonas/farmacologia , Treonina/química , Treonina/farmacologia , Tirosina/química , Tirosina/farmacologiaRESUMO
This study was conducted to evaluate the antimutagenic and antimicrobial activities of Schiff bases attached L-glutamine and L-asparagine. Antibacterial activities of the compounds against S. aureus, Sh. dys. typ 7, L. monocytogenes 4b, E. coli, S. typhi H, S. epidermis, Br. abortus, M. luteus, B. cereus, P. putida, and antifungal activity against Candida albicans were studied. These compounds were investigated for antimutagenic properties against Aflatoxin Bi (AFBi) using micronuclei (MN) assay in human lymphocyte cell culture in vitro. The protective role of these compounds against AFBi-induced MN is probably related to its doses.
Assuntos
Asparagina/química , Asparagina/farmacologia , Glutamina/química , Glutamina/farmacologia , Antibacterianos/química , Antibacterianos/farmacologia , Antifúngicos/química , Antifúngicos/farmacologia , Antimutagênicos/química , Antimutagênicos/farmacologia , Bactérias/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Feminino , Humanos , Linfócitos/efeitos dos fármacos , Linfócitos/metabolismo , Masculino , Manganês/química , Testes para Micronúcleos , Bases de Schiff/químicaRESUMO
The in vitro antibacterial and antifungal activities of five different amino acid Schiff bases derived from the reaction of 2-hydroxy-1-naphthaldehyde with glycine, L-alanine L-phenylalanine, L-histidine, L-tryptophane and the manganese(III) complexes of these bases were investigated. Structures of the Schiff bases were proven by 1H-NMR. In vitro activities against some Gram-positive (Staphylococcus aureus and Bacillus polymyxa) and Gram-negative (Escherichia coli) bacteria and the fungus Candida albicans were determined. The antimicrobial activities tended to decrease with the increasing size of the amino acid residues.
