1.
Pol J Pharmacol Pharm
; 32(5): 725-9, 1980.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6267566
RESUMO
Adenosine abolished action potentials and slowed down depolarization in the sinus node cells, and depressed the slow component in the working fibers. Noradrenaline and dibutryl cAMP did not counteract the effects of adenosine in the working myocardium whereas in the pacemaker, dibutryl cAMP alone evoked low frequency spontaneous activity.
Assuntos
Adenosina/farmacologia , Coração/efeitos dos fármacos , Potenciais de Ação/efeitos dos fármacos , Animais , Bucladesina/farmacologia , AMP Cíclico/fisiologia , Cobaias , Coração/fisiologia , Técnicas In Vitro
2.
Naunyn Schmiedebergs Arch Pharmacol
; 313(1): 9-10, 1980 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7207639
RESUMO
Histamine restored spontaneous activity in the isolated rabbit sinus node arrested with reserpine. This fact suggests that catecholamines are not the unique activators of adenylate cyclase required for cardiac pacemaking, and may be replaced by histamine.
