Oral nutritional supplementation in patients undergoing peritoneal dialysis: a randomised, crossover pilot study.

BACKGROUND: Malnutrition is a significant problem in those undergoing peritoneal dialysis (PD). Factors such as gastrointestinal (GI) symptoms and the need for a fluid reduced diet can limit tolerance and thereby the efficacy of oral nutritional supplements to treat malnutrition. OBJECTIVES: To evaluate the acceptability and impact of two different forms of oral nutrition supplementation for 16 weeks on nutritional markers and quality of life of malnourished patients undergoing PD. DESIGN: A randomised, within-subject cross-over study. Patients assessed as malnourished or with serum albumin <35 g/l were recruited. Participants were randomised to receive either 200 ml of a 1.25 kcal/ml nutrition supplement or a high protein nutrition supplement bar, for eight weeks. Each group then crossed over to receive the alternative supplement for eight weeks. Total intervention time was 16 weeks. Serum albumin, serum transthyretin and food intake were evaluated at baseline, at 8 and 16 weeks. Subjective Global Assessment, the presence of GI symptoms and quality of life were evaluated at baseline and 16 weeks. RESULTS: Sixteen weeks of nutritional support was associated with statistically significant improvements in weight and a reduction in the proportion of patients who were malnourished. There was no difference in the impact of bars compared with liquid oral nutrition supplementation. Patients preferred the fluid supplement to the bars. CONCLUSION: Sixteen weeks of nutritional support improved nutritional status in malnourished patients on PD.

Weight management strategies for those with chronic kidney disease: A consensus report from the Asia Pacific Society of Nephrology and Australia and New Zealand Society of Nephrology 2016 renal dietitians meeting.

AIM: The aim of the present study was to develop a consensus report to guide dietetic management of overweight or obese individuals with chronic kidney disease (CKD). METHODS: Six statements relating to weight management in CKD guided a comprehensive review of the literature. A summary of the evidence was then presented at the renal nutrition meeting of the 2016 Asia Pacific Society of Nephrology and Australia and New Zealand Society of Nephrology. Majority agreement was defined as group agreement on a statement of between 50-74%, and consensus was considered ≥75% agreement. The recommendations were developed via a mini Delphi process. RESULTS: Two statements achieved group consensus: the current guidelines used by dietitians to estimate energy requirements for overweight and obese people with CKD are not relevant and weight loss medications may be unsafe or ineffective in isolation for those with CKD. One statement achieved group agreement: Meal replacement formulas are safe and efficacious in those with CKD. No agreement was achieved on the statements of whether there is strong evidence of benefit for weight loss prior to kidney transplantation; whether traditional weight loss strategies can be used in those with CKD and if bariatric surgery in those with end stage kidney disease is feasible and effective. CONCLUSION: There is a limited evidence base to guide the dietetic management of overweight and obese individuals with CKD. Medical or surgical strategies to facilitate weight loss are not recommended in isolation and require a multidisciplinary approach with the involvement of a skilled renal dietitian.

Peritoneal dialysis patients have higher prevalence of gastrointestinal symptoms than hemodialysis patients.

OBJECTIVE: Malnutrition is common in dialysis patients and is attributed to decreased food intake, and/or chronic systemic inflammation linked to dialysis-related comorbidities and complications. This study aimed to determine the prevalence of gastrointestinal (GI) symptoms in dialysis patients and whether this impacts food intake. DESIGN: Cross-sectional study. SETTING: Tertiary teaching hospital. PARTICIPANTS: All consenting hospital peritoneal dialysis (PD) and hemodialysis (HD) patients. METHODS: Patients were interviewed by a dietitian regarding the prevalence and impact of GI symptoms (nausea, vomiting, bloating, early satiety, diarrhea, heartburn, fatigue, and weight changes). Serum levels of albumin were measured, and the use of medication known to cause GI symptoms was recorded. MAIN OUTCOME MEASURE: Presence of GI symptoms. RESULTS: The PD (n = 122) and HD (n = 172) groups were similar in age, gender, and presence of diabetes. Serum albumin levels were lower for those on PD compared with HD (3.2 vs. 3.5 g/dL, P < .001). Eighty-five percent of the patients on PD reported at least 1 GI symptom, compared with 51% on HD. Compared with HD, more PD patients reported that GI symptoms were related to the onset of dialysis (55% vs. 12%, P < .001). A greater number of PD patients (compared with HD patients) reported a decrease in food intake (53% vs. 14%, P < .001) and that they had attempted dietary changes to alleviate symptoms (34% vs. 9%, P < .001). CONCLUSION: These results should influence dietetic educational practice. In addition to the provision of adequate protein and energy, dialysis patients should be counselled regarding the management of GI symptoms and monitored for the prevalence and severity of these symptoms.