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1.
Rev. chil. neuro-psiquiatr ; 59(3): 197-203, sept. 2021.
Artigo em Espanhol | LILACS | ID: biblio-1388398

RESUMO

INTRODUCCIÓN: La depresión es una patología de alta prevalencia en los adultos mayores, estando asociada a mayor morbimortalidad. Existen escasos estudios sobre prevalencia y caracterización de pacientes geriátricos hospitalizados con síntomas depresivos. MÉTODO: Se entrevistaron pacientes entre enero y marzo de 2020. Criterios de Inclusión: edad > 60 años, admitidos en las últimas 48 horas. CRITERIOS DE EXCLUSIÓN: Pfeiffer ≥ 3, Glasgow < 15, afasia, enfermedad mental, no hispanohablante. RESULTADOS: Se entrevistaron 59 pacientes, 32 mujeres y 27 varones, edad promedio 73,32 (DE 6,63). La prevalencia de test Yesavage-15 positivo fue 32,20% (19), 52,63% (10) en mujeres y 47,37% (9) en hombres. CONCLUSIONES: Los síntomas depresivos en adultos mayores admitidos en un Servicio de Medicina Interna son frecuentes, y no siempre pesquisados durante la hospitalización. La relación significativa entre Yesavage positivo e ideación suicida destaca el rol de los trastornos del ánimo en el suicidio en población geriátrica.


INTRODUCTION: Depression is a highly prevalent pathology in the elderly, associated to higher morbimortality. There are few studies on prevalence and characterization of hospitalized geriatric patients with depressive symptoms. METHOD: Patients were interviewed between january and april 2020. Inclusion criteria: age over 60 years old, admitted in the last 48 hours. EXCLUSION CRITERIA: Pfeiffer ≥ 3, Glasgow < 15, aphasias, mental diseases, no spanish-speaker. RESULTS: 59 patients were interviewed, 32 women and 27 men, mean age of 73,32 (DE 6.63) years old. Positive Yesavage score prevalence was 32,20% (19), 52,63% (10) in women and 47,37% (9) in men. CONCLUSIONS: Depressive symptoms in patients admitted to an Internal Medicine service are frequent, and often undetected during hospitalization.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Depressão/epidemiologia , Geriatria , Hospitalização , Prevalência , Entrevistas como Assunto , Depressão/diagnóstico
2.
Lett Appl Microbiol ; 70(5): 372-379, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32048742

RESUMO

Pseudomonas aeruginosa is a prominent member of emerging waterborne pathogens. The environmental reservoirs of multi-resistant phenotypes and other virulence factors in this bacterium are poorly understood. Our study aimed to determine the virulence properties of P. aeruginosa isolated from Roraima Sur Cave (RSC) waters at Guayana Highlands. Based on the best identification at species level by biochemical tests, 16S rRNA sequencing and phylogenetic inferences, one RSC isolate named LG11 was characterized for virulence properties in comparison with P. aeruginosa reference strains. PCR amplification of alginate, elastase, exoenzyme S, exotoxin A, neuraminidase and Quorum-Sensing genes showed a high virulence potential in LG11. This isolate demonstrated multi-resistance to ceftriaxone, tigecycline and imipenem. Pyocyanin production was greater in LG11 (0·478 µg ml-1 ) than the strain ATCC 10145 (0·316 µg ml-1 ), but the highest pigment concentration (2·140 µg ml-1 ) was displayed by the clinical strain CVCM 937 (P = 0·000175). Pronounced biomass production on granite and glass (P < 0·05) and well-developed biofilms indicated the ability of P. aeruginosa from RSC to colonize surfaces found in human and healthcare environments. These data suggest that waters from pristine ecosystems such as RSC could be reservoirs of this opportunistic bacterium carrying important virulence properties with potential epidemiological implications. SIGNIFICANCE AND IMPACT OF THE STUDY: This study shows for the first time the occurrence of virulence genes and multi-resistance to antimicrobials in Pseudomonas aeruginosa isolated from cave waters at Guayana Highlands. These findings, together with the biofilm formation on surfaces found in human and healthcare settings, suggest public health risks and the potential of these virulence properties to be transferred from or to native populations in waters. Our results provide important insights to the current knowledge of P. aeruginosa in the environment, setting the basis for future studies driven to assess reservoirs of multi-resistant bacteria and virulence features unknown in pristine ecosystems.


Assuntos
Cavernas/microbiologia , Pseudomonas aeruginosa/efeitos dos fármacos , Pseudomonas aeruginosa/patogenicidade , Fatores de Virulência/genética , Microbiologia da Água , Antibacterianos/farmacologia , Biofilmes/crescimento & desenvolvimento , Farmacorresistência Bacteriana/efeitos dos fármacos , Ecossistema , Testes de Sensibilidade Microbiana , Filogenia , Pseudomonas aeruginosa/isolamento & purificação , Piocianina/biossíntese , Percepção de Quorum , RNA Ribossômico 16S/genética , Venezuela , Virulência
3.
Ig Sanita Pubbl ; 75(3): 231-244, 2019.
Artigo em Italiano | MEDLINE | ID: mdl-31645064

RESUMO

The increase of chronic diseases prevalence has created the need to adapt care models. Telemedicine applications play an increasingly important role in health care and provide tools that are indispensable for home health care, remote patient monitoring, disease management, and lastly are enable patients to have more control of their own well being. The paper presents an Italian Healthcare Local Authority Experience. The objective of paper was to evaluate the impact of telemedicine on patients with long-term conditions at high risk for rehospitalization or an emergency department visit, in terms of target disease control (diabetes, hypertension, heart failure, and chronic obstructive pulmonary disease). The outcomes are highly positive. They register the decrease of access to emergency care, the reduction of waiting list for the next visits and the increase of customer satisfaction.


Assuntos
Doença Crônica/terapia , Serviços de Assistência Domiciliar , Telemedicina , Diabetes Mellitus , Humanos , Readmissão do Paciente , Doença Pulmonar Obstrutiva Crônica
4.
Sci Total Environ ; 676: 455-468, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31048175

RESUMO

Rhodolith beds, like many other marine ecosystems, are affected by climate change that is causing an increase in the magnitude and frequency of extreme high temperature events (heat waves). Unfortunately, this does not represent the sole peril for these communities, as coastal urbanization in conjunction with altered precipitation patterns can increase terrestrial-derived nutrient input. In Brazil, rhodolith beds are among the most extensive coastal benthic ecosystems, but despite their vast distribution and great ecological and economic importance, studies on the productivity of these communities and the impact of changing environmental conditions are almost non-existent. This study addressed the individual and combined effects of increases in temperature and nutrient concentration on the physiological performance of two widely distributed rhodolith species, Lithothamnion crispatum and Melyvonnea erubescens. The results showed species-specific responses in net photosynthetic performance, with no response in L. crispatum, while M. erubescens responded negatively to both increase in temperature and nutrients. In contrast, calcification in both species showed a significant decline at high temperature. No interactive effects were found between temperature and nutrients, yet their combined negative effects were additive, resulting in negative daily-integrated net productivity and a large decline in daily carbonate production in both species. This has strong implications for rhodolith bed primary productivity and carbonate production, as heat waves may potentially cause a strong decline in carbonate production (ca. 50% loss), accompanied by a severe drop in primary productivity that will be even more pronounced under high-nutrient conditions. Also, the species-specific responses to changes in temperature and nutrient concentration suggest that the magnitude of impact of these factors on rhodolith bed productivity will depend on the species dominating the community and may finally result in changes in rhodolith community composition.


Assuntos
Mudança Climática , Ecossistema , Rodófitas/fisiologia , Brasil , Carbonatos , Monitoramento Ambiental , Concentração de Íons de Hidrogênio , Nitrogênio/análise , Oceanos e Mares , Fósforo/análise , Fotossíntese , Água do Mar/química , Temperatura
5.
Andrologia ; 50(1)2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28421619

RESUMO

Chlamydia trachomatis is considered as the bacterium that is more sexually transmitted as cause of male urethritis, epididymitis, orchitis and infertility. A total of 116 semen samples of men whose couples are infertile women were analysed. The quality of the semen was measured by standard procedures recommended by WHO while C. trachomatis was detected by the PCR assay. Thirty-seven semen samples were positive for C. trachomatis (31.9%). Regarding semen analysis, no different values were observed between positive and negative samples to C. trachomatis. However, the presence of leucocytes and erythrocytes suggests an inflammatory process; however, these were high in negative samples to C. trachomatis. Furthermore, an association between low seminal volume at 1, 5 ml and the positivity to C. trachomatis was observed (OR=2, 1; CI95 % 1,16-3,07). The total semen volume is a contribution by the various accessory glands (this reflects the secretory activity of the glands); a low semen volume could be due to an obstruction of the ejaculatory duct or infection of accessory glands by C. trachomatis. More studies are necessary to identify the causes of a reduced semen volume.


Assuntos
Infecções por Chlamydia/complicações , Chlamydia trachomatis/isolamento & purificação , Infertilidade Feminina/microbiologia , Sêmen/microbiologia , Parceiros Sexuais , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Análise do Sêmen , Adulto Jovem
6.
Bol. micol. (Valparaiso En linea) ; 32(1): 13-18, jun. 2017. ilus
Artigo em Espanhol | LILACS | ID: biblio-982637

RESUMO

El género Macrolepiota cuenta con 30 especies ampliamente distribuidas en el mundo, siendo éstas saprobiontes. En Chile se han documentado tres especies: M. procera, M. bonaerensis y M. rachodes, perteneciendo actualmente esta última al género Chlorophyllum. En esta revisión, se describen según la literatura los caracteres macromorfológicos y microscópicos de las tres especies mencionadas con anterioridad. Adicionalmente, se adaptó una clave dicotómica en base a la bibliografía para facilitar la determinación de las especies.


The Macrolepiota genus include 30 species widely distributed around the world, being these saprobionts. In Chile, three species have been documented: M. procera, M. bonaerensis y M. rachodes, at present the last specie currently belong to the genus Chlorophyllum. In this review, the macromorphological, and microscopic characteristics of the three species mentioned above are described according to the literature. In addition, a dichotomous key was adapted based on the bibliography to facilitate the determination of the species.


Assuntos
Agaricales/classificação , Agaricales/citologia , Basidiomycota , Ecossistema , Chile , Ecologia
9.
Bol. micol. (Valparaiso En linea) ; 31(2): 23-35, dic. 2016.
Artigo em Espanhol | LILACS | ID: biblio-868813

RESUMO

A lo largo de la historia numerosos investigadores han intentado estudiar la sociología de los hongos, también llamada micosociología que se refiere al estudio y la clasificación de las comunidades fúngicas, sus interrelaciones y su dependencia del medio. La mayoría de estos estudios han sido realizados en Europa, donde destacan los trabajos realizados por Darimont (1973) y García Bona (1977). Son pocos los estudios de carácter micosociológico que describen la interacción de ciertos macromicetos con especies de Nothofagus de América del Sur, destacando los de Godeas et al. (1993 a, b, c) en bosques de Nothofagus de Tierra del Fuego y el de Valenzuela et al. (1998). En esta revisión, se exponen los comienzos históricos de la micosociología, su evolución a lo largo de los años y cómo su enfoque ayuda a comprender el funcionamiento de las comunidades fúngicas. También, se destaca la importancia que tiene para nuestro país realizar estudios micosociológicos, especialmente, en bosques nativos dominados por Nothofagus.


Over time many researchers have tried to study the sociology of fungi, or mycosociology, meaning the study and classification of fungal communities, their inter-relations and their dependence on the medium. The majority of these studies have been carried out in Europe, notably the works of Darimont (1973) and García Bona (1977). There are few mycosociological studies which describe the interaction of certain macromycetes with South American Nothofagus species. Important studies are Godeas et al. (1993 a, b, c), in Nothofagus forests in Tierra del Fuego, and Valenzuela et al. (1998). This review examine the historical beginnings of mycosociology, its evolution over time and how its focus helps to understand the functioning of fungal communities. The autor also stress the importance for Chile of carrying out mycosociological studies, especially in native forests dominated by Nothofagus.


Assuntos
Humanos , Micobioma , Fatores Sociológicos , Fungos
10.
Rev. calid. asist ; 31(4): 220-226, jul.-ago. 2016. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-153997

RESUMO

Objetivo. Describir la estancia media (EM) de la embolia de pulmón (EP) en una unidad de trombosis (UT) dependiente de una unidad de corta estancia (UCE) de un hospital de tercer nivel. Comparar estos datos con el resto de hospitales de nuestra región, con los del resto de comunidades autónomas (CCAA) y con el mismo hospital durante un año previo a nuestra existencia. Material y método. Estudio observacional retrospectivo descriptivo en el que se incluyeron los pacientes con diagnóstico de EP en el Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA) durante el año 2012. Clasificamos estos datos por servicio hospitalario, calculando la EM. Comparamos esta con la del resto de hospitales de nuestra región, con el resto de CCAA y con nuestros datos en el año 2007, cuando no existía aun la UT. Resultados. Se incluyeron 113 pacientes: 60 (53%) ingresaron en la UT, siendo la EM de 4,39 días, en Oncología, de 7,45, y en Medicina Interna (MI), de 15,38. No hubo ningún fallecido en la UT y solo se produjeron 3 reingresos (5%). Los datos publicados mostraron que la EM en todos los hospitales de nuestra región fue de 8,25 días; en nuestro hospital fue de 5,18 días y en el resto de hospitales, mayor. La CCAA con mejor EM fue el País Vasco con 6,85 días. En el año 2007, hubo 70 pacientes con EP en el HCUVA: 34 (49%) en MI con una EM de 8,50 días, 11 (31%) en Oncología con una EM de 9,64 días y 3 (4,3%) en Neumología, con una EM de 19 días; la mortalidad global fue del 11% y la tasa de reingresos en MI, del 6%. Conclusión. La EM de la EP en la UT en una UCE fue menor que en el resto de servicios de nuestro hospital, menor que en el resto de hospitales de nuestra comunidad, menor que en el resto de CCAA y menor que en cualquier servicio de nuestro hospital en una época anterior a nuestra existencia, sin aumentar la tasa de reingreso ni la mortalidad (AU)


Objectives. To determine the mean stay (MS) of patients with pulmonary embolism (PE) in a thrombosis unit (TU) with a short stay unit (SSU) in a tertiary hospital. To compare the data collected with those of other hospitals in the same region, of other regions (Autonomous Communities [AACC]), and within the same hospital in the year before the SSU opened. Material and methods. A descriptive retrospective observational study that included patients with a diagnosis of PE in the University Hospital Virgen de la Arrixaca (HCUVA) in 2012. These data were classified by hospital department, and used for calculating the mean stay. This was then compared with that of other hospitals in our region, with the rest of the regions, and with the data in 2007 (the last year without a TU). Results. A total of 113 patients with PE were included, 60 (53%) in the TU with an MS of 4.39, in Oncology, 7.45, and Internal Medicine (IM), 15.38 days. There were no deaths in the TU and only 3 (5%) readmissions. Published data showed that the MS in all hospitals in our region was 8.25, 5.18 in our hospital, and higher in the rest of hospitals. The best AACC was the Basque Country with an MS of 6.85 days. In 2007, there were 70 patients with PE in the HCUVA, 34 (49%) in IM, with an MS of 8.50, Oncology 11 (31%) with an MS 9.64, and Chest Diseases 3 (4.3%) with an MS 19 days, and with an overall mortality of 11% and a rate of readmissions in IM of 6%. Conclusion. The mean stay for a PE in the SSU of a TU was lower than in the rest of the hospital departments, lower than the rest hospitals of our region, lower than the rest of the regions, and lower than any department of our hospital before the SSU existed, without increasing the readmission or mortality rate (AU)


Assuntos
Humanos , Masculino , Feminino , Embolia Pulmonar/epidemiologia , Embolia Pulmonar/prevenção & controle , Embolia Pulmonar/terapia , Tempo de Internação/economia , Trombose/complicações , Trombose/terapia , Estudos Retrospectivos , Hospitalização/economia , Hospitalização/estatística & dados numéricos , Demografia/classificação
11.
Radiologia ; 58 Suppl 1: 115-27, 2016 Apr.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-26976664

RESUMO

Spinal misalignments are a common reason for consultation at primary care centers and specialized departments. Misalignment has diverse causes and is influenced by multiple factors: in adolescence, the most frequent misalignment is scoliosis, which is idiopathic in 80% of cases and normally asymptomatic. In adults, the most common cause is degenerative. It is important to know the natural history and to detect factors that might predict progression. The correct diagnosis of spinal deformities requires specific imaging studies. The degree of deformity determines the type of treatment. The aim is to prevent progression of the deformity and to recover the flexibility and balance of the body.


Assuntos
Curvaturas da Coluna Vertebral , Humanos , Curvaturas da Coluna Vertebral/diagnóstico por imagem , Curvaturas da Coluna Vertebral/etiologia
13.
Rev Calid Asist ; 31(4): 220-6, 2016.
Artigo em Espanhol | MEDLINE | ID: mdl-26705912

RESUMO

OBJECTIVES: To determine the mean stay (MS) of patients with pulmonary embolism (PE) in a thrombosis unit (TU) with a short stay unit (SSU) in a tertiary hospital. To compare the data collected with those of other hospitals in the same region, of other regions (Autonomous Communities [AACC]), and within the same hospital in the year before the SSU opened. MATERIAL AND METHODS: A descriptive retrospective observational study that included patients with a diagnosis of PE in the University Hospital Virgen de la Arrixaca (HCUVA) in 2012. These data were classified by hospital department, and used for calculating the mean stay. This was then compared with that of other hospitals in our region, with the rest of the regions, and with the data in 2007 (the last year without a TU). RESULTS: A total of 113patients with PE were included, 60 (53%) in the TU with an MS of 4.39, in Oncology, 7.45, and Internal Medicine (IM), 15.38days. There were no deaths in the TU and only 3 (5%) readmissions. Published data showed that the MS in all hospitals in our region was 8.25, 5.18 in our hospital, and higher in the rest of hospitals. The best AACC was the Basque Country with an MS of 6.85days. In 2007, there were 70patients with PE in the HCUVA, 34 (49%) in IM, with an MS of 8.50, Oncology 11 (31%) with an MS 9.64, and Chest Diseases 3 (4.3%) with an MS 19days, and with an overall mortality of 11% and a rate of readmissions in IM of 6%. CONCLUSION: The mean stay for a PE in the SSU of a TU was lower than in the rest of the hospital departments, lower than the rest hospitals of our region, lower than the rest of the regions, and lower than any department of our hospital before the SSU existed, without increasing the readmission or mortality rate.


Assuntos
Embolia Pulmonar/terapia , Centros de Atenção Terciária , Humanos , Tempo de Internação , Embolia Pulmonar/diagnóstico , Estudos Retrospectivos , Espanha
15.
Bol. micol. (Valparaiso En linea) ; 30(2): 28-39, dic. 2015. ilus, graf
Artigo em Espanhol | LILACS | ID: biblio-868803

RESUMO

Los bosques de Nothofagus de la zona mediterránea de Chile, que incluye la VII Región, están constituidos por especies caducifolias y siempreverdes, las cuales se encuentran asociadas a diversos hongos ectomicorrícicos dentro de los que destaca el hongo nativo Cortinarius austroturmalis Moser & Horak (Agaricales, Basidiomycota). Este hongo constituye un Producto Forestal No Maderero (PFNM) poco conocido, cuya productividad no ha sido determinada, lo que implica que la población rural cercana a las Reservas Nacionales Altos de Lircay y Los Ruiles de la VII Región, no lo identifique como un hongo apto para el consumo humano y, por consiguiente, no lo coseche. El objetivo de esta investigación fue conocer la productividad de basidiomas del hongo nativo Cortinarius austroturmalis asociado a especies de Nothofagus siempreverdes y caducifolias en las Reservas Nacionales Altos de Lircay y Los Ruiles de la VII Región. Las hipótesis propuestas fueron: 1) La productividad de basidiomas de Cortinarius austroturmalis en la Reserva Nacional Los Ruiles es mayor que en la Reserva Nacional Altos de Lircay, 2) La productividad de basidiomas de Cortinarius austroturmalis asociados a especies de Nothofagus siempreverdes es mayor que la productividad de este hongo asociado a especies de Nothofagus caducifolias en ambas reservas estudiadas.


Nothofagus forests in the Mediterranean region of Chile, including VII Region consist of deciduous and evergreen species, which are associated with different ectomycorrhizal fungi within which highlights the native mushroom Cortinarius austroturmalis Moser & Horak (Agaricales, Basidiomycota). This fungus is a Non-Wood Forest Product (NWFP) obscure, whose productivity has not been determined, implying that close to the National Reserves Altos de Lircay and Los Ruiles, VII Region, rural population does not identify it a fungus suitable for human consumption and therefore not harvested. The objective of this research was to determine the productivity of fruit body of the native mushroom Cortinarius austroturmalis associated with Nothofagus species of evergreen and deciduous in the National Reserves Altos de Lircay and Los Ruiles, VII Region. The proposed hypotheses were: 1) Productivity of Cortinarius austroturmalis in the National Reserve Los Ruiles is higher than in the National Reserve Altos de Lircay, 2) Productivity of Cortinarius austroturmalis associated with Nothofagus species evergreen is greater than the productivity of this fungus associated with deciduous Nothofagus species in both reserves studied.


Assuntos
Agaricales/isolamento & purificação , Agaricales/crescimento & desenvolvimento , Cortinarius/isolamento & purificação , Cortinarius/crescimento & desenvolvimento , Produção de Alimentos , Micorrizas , Basidiomycota , Biomassa , Chile , Clima , Agricultura Florestal , Florestas , Reservas Naturais , Umidade do Solo
17.
J Thromb Haemost ; 13(7): 1274-8, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25980766

RESUMO

BACKGROUND: No studies have identified which patients with upper-extremity deep vein thrombosis (DVT) are at low risk for adverse events within the first week of therapy. METHODS: We used data from Registro Informatizado de la Enfermedad TromboEmbólica to explore in patients with upper-extremity DVT a prognostic score that correctly identified patients with lower limb DVT at low risk for pulmonary embolism, major bleeding, or death within the first week. RESULTS: As of December 2014, 1135 outpatients with upper-extremity DVT were recruited. Of these, 515 (45%) were treated at home. During the first week, three patients (0.26%) experienced pulmonary embolism, two (0.18%) had major bleeding, and four (0.35%) died. We assigned 1 point to patients with chronic heart failure, creatinine clearance levels 30-60 mL min(-1) , recent bleeding, abnormal platelet count, recent immobility, or cancer without metastases; 2 points to those with metastatic cancer; and 3 points to those with creatinine clearance levels < 30 mL min(-1) . Overall, 759 (67%) patients scored ≤ 1 point and were considered to be at low risk. The rate of the composite outcome within the first week was 0.26% (95% confidence interval [CI] 0.004-0.87) in patients at low risk and 1.86% (95% CI 0.81-3.68) in the remaining patients. C-statistics was 0.73 (95% CI 0.57-0.88). Net reclassification improvement was 22%, and integrated discrimination improvement was 0.0055. CONCLUSIONS: Using six easily available variables, we identified outpatients with upper-extremity DVT at low risk for adverse events within the first week. These data may help to safely treat more patients at home.


Assuntos
Técnicas de Apoio para a Decisão , Pacientes Ambulatoriais , Embolia Pulmonar/etiologia , Trombose Venosa Profunda de Membros Superiores/etiologia , Adulto , Idoso , Anticoagulantes/efeitos adversos , Canadá , Europa (Continente) , Feminino , Hemorragia/induzido quimicamente , Humanos , Israel , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/mortalidade , Embolia Pulmonar/prevenção & controle , Sistema de Registros , Medição de Risco , Fatores de Risco , América do Sul , Fatores de Tempo , Resultado do Tratamento , Trombose Venosa Profunda de Membros Superiores/diagnóstico , Trombose Venosa Profunda de Membros Superiores/mortalidade , Trombose Venosa Profunda de Membros Superiores/terapia
18.
Dalton Trans ; 44(15): 6987-98, 2015 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-25780987

RESUMO

The reactivity of different heteroscorpionate ligands based on bis(pyrazol-1-yl)methane, with different iridium-(i) and -(iii) precursors is reported. The reaction of the heteroscorpionate lithium salts "Li(bdmpza)", [bdmpza = bis(3,5-dimethylpyrazol-1-yl)acetate], "Li(bdmpzdta)" [bdmpzdta = bis(3,5-dimethylpyrazol-1-yl)dithioacetate] and "Li(S)-mbpam" [(S)-mbpam = (S)-(-)-N-α-methylbenzyl-2,2-bis(3,5-dimethylpyrazol-1-yl)acetamidate] with 1 equivalent of [IrCl3(THF)3] in THF for 18 h affords high yields of neutral and anionic heteroscorpionate chloride iridium complexes [IrCl2(bdmpza)(THF)] (), [Li(THF)4][IrCl3(bdmpzdta)] () and [IrCl2{(S)-mbpam})(THF)] (). Solution of complex in acetonitrile at room temperature leads to complex [IrCl2{(S)-mbpam})(NCCH3)] (). Complexes and were isolated as enantiopure compounds. The reaction of the lithium salt "Li(bdmpza)" with [IrCl(η(4)-CH2[double bond, length as m-dash]C(Me)C(Me)[double bond, length as m-dash]CH2)]2 in THF for 18 h gave the Ir(i) complex [Ir(bdmpza)(η(4)-CH2[double bond, length as m-dash]C(Me)C(Me)[double bond, length as m-dash]CH2)] (). The reaction of complex with CO (2 atm) at room temperature leads to a new complex of Ir(iii), [Ir(bdmpza)(k(2)-CH2C(Me)[double bond, length as m-dash]C(Me)CH2)(CO)] (). Treatment of heteroscorpionate ligand precursors "Li(bdmpza)" and "Li(bdmpzdta)" with [IrCp*Cl2]2 in THF yielded the iridium(iii) complexes [Ir2Cp*2Cl2(bdmpzx)] (x = a , x = dta ). These complexes have helical chirality due to the demands of the fixed pyrazole rings. The stereoisomerism and the self-assembly processes of these helicates have been studied in some detail in solution by NMR spectroscopy and in the solid state by X-ray diffraction. Mixtures of M- and P-handed enantiomers were obtained. Complex undergoes a decarboxylation process initiated by the HCl generated in the previous step leading to the known ionic complex [IrClCp*(bdmpm)][IrCl3Cp*] [bdmpm = bis(3,5-dimethylpyrazol-1-yl)methane] (). The structures of the complexes were determined by spectroscopic methods and the X-ray crystal structures of , , and were also established.

20.
Plant Dis ; 99(8): 1153-1160, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30695943

RESUMO

The Kenyan wheat (Triticum aestivum L.) 'Kenya Kongoni' exhibits high levels of adult plant resistance (APR) to leaf rust (LR) and yellow rust (YR). We determined the genomic regions associated with LR and YR resistance in a population of 148 recombinant inbred lines generated from a cross between 'Avocet-YrA' and Kenya Kongoni. Field experiments to characterize APR to LR and YR were conducted in four and two Mexican or Uruguayan environments, respectively. A linkage map was constructed with 438 diversity arrays technology and 16 simple-sequence repeat markers by JoinMap 4.1 software. Genetic analyses showed that resistance to both rusts was determined by four to five APR genes, including Lr46/Yr29 and Sr2/Lr27/Yr30. Quantitative trait loci (QTL) analysis indicated that pleiotropic APR loci QYLr.cim-1BL corresponding to Lr46/Yr29 and QYLr.cim-7BL that is a putative novel QTL accounted for 5 to 57% and 12 to 35% of the phenotypic variation for resistance to LR and YR, respectively. These loci, in combination with another three LR QTL and two YR QTL, respectively, conferred high levels of resistance to both LR and YR in wheat under Mexican and Uruguayan environments. Among other detected QTL, QLr.cim-1DS, QLr.cim-2BL, and QYLr.icm-7BL may be new loci for APR to both rusts in common wheat.

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