Synthesis, Characterization, and Preliminary In Vitro Cytotoxic Evaluation of a Series of 2-Substituted Benzo [d] [1,3] Azoles.

A series of benzo [d] [1,3] azoles 2-substituted with benzyl- and allyl-sulfanyl groups were synthesized, and their cytotoxic activities were in vitro evaluated against a panel of six human cancer cell lines. The results showed that compounds BTA-1 and BMZ-2 have the best inhibitory effects, compound BMZ-2 being comparable in some cases with the reference drug tamoxifen and exhibiting a low cytotoxic effect against healthy cells. In silico molecular coupling studies at the tamoxifen binding site of ERα and GPER receptors revealed affinity and the possible mode of interaction of both compounds BTA-1 and BMZ-2.

A silver bite: crystalline heterometallic architectures based on Ag-π interactions with a bis-dipyrrin zinc helicate.

An unprecedented mode of assembly of helical motives and Ag(I)  ions in the crystalline state is described. The combination of a Zn(II) helicate based on a 2,2'-bisdpm bearing peripheral benzonitrile moieties with AgX salts, leads to the formation of a tetranuclear core containing Ag-π interactions. Depending on the coordinating ability of the X(-) anion and the solvents used, the tetranuclear complex self-assembles into coordination polymers of varying dimensionality. From the sequence of coordination events (Ag-π or Ag-peripheral site), one may envisage two possible construction scenarios. However, the Ag-π as primary event seems reasonable owing to the rather weak binding propensity of the nitrile group and the chelating nature of the π-clefts.

N-containing boronic esters as self-complementary building blocks for the assembly of 2D and 3D molecular networks.

The combination of two heteroaromatic boronic acids with pentaerythritol gave self-complementary tectons which were suitable for the generation of 2D and 3D molecular networks.

3-Pyridineboronic acid --> boroxine --> pentadecanuclear boron cage --> 3D molecular network: a sequence based on two levels of self-complementary self-assembly.

A pentadecanuclear boroxine-cage has been generated through a single-component self-assembly process, and serves as a twofold concave-convex self-complementary tecton for the assembly of a complex 3D molecular network.

Many faces of dipyrrins: from hydrogen-bonded networks to homo- and heteronuclear metallamacrocycles.

The amphoteric 5-(4-cyanophenyl)dipyrrin ligand, offering three distinct states, i.e., cationic, neutral, and anionic, has been exploited for the formation of a 1-D hydrogen-bonded network in its protonated form and both homo- and heterobinuclear metallamacrocycles, in its neutral and deprotonated states, respectively, with a variety of coordination modes.

Beyond classical coordination: silver-pi interactions in metal dipyrrin complexes.

Homo- and hetero-leptic Zn and Cu complexes of dipyrrin type ligands bearing mono- and di-cyanophenyl groups when combined with silver cations lead to the formation of Ag(I)-C=C double bond interactions unprecedented in the crystalline phase.

Arranging up to six ferrocene carboxamides around metal centres.

Ferrocene carboxamide, FcCONH(2), forms homo- and heteroleptic complexes with Co(II), Ni(II) and Cu(II) via coordination of its carbonyl group. Whereas for both Co(II) and Ni(II), hexaferrocenyl complexes are obtained in the presence of BF(4)(-) anion, in the case of Cu(II) a tetraferrocenyl species is observed in the presence of triflate anion.