[Fermental (plasmin) blood system in patients with acute viral myocarditis].

For the first time it is established that patients with acute virus myocarditis (AVM) at all stages of severity of clinical course of the disease have changes in indicators of fibrinogens, soluble complexes of monomeric fibrin, products of its degradation, activated plasminogen, time recalcification of blood plasma to blood heparin, fibrinolytic activity of plasma, spontaneous fibrinolysis, time of lysis of euglobulin clot, blood heparin, antithrombin III, platelets. It testifies to suppression of fibrinolysis processes which expressiveness statistically reliably correlates with degree of severity of clinical course of AVM. Application of medicamentous correction is necessary for prevention of the development of disseminated intravascular blood coagulation syndrome.

[Enzymatic (plasmin) blood system in patients with acute virus myocarditis and its medical correction].

For the first time it is established that changes of parametres of coagulation hemostasis (fibrinogen Fg, soluble complexes of monomeasured fibrin -SCMF, products of fibrin degradation-PFD, 1st and 2nd waves of platelet aggregation), platelet hemostasis (platelets, a range index of platelet contact activation -RIPCA, activated partial platelet time--APPT, a total index thrombophilia TIT, platelet time--PT, prothrombin time (Prv), physiological anticoagulants (blood heparin-BH, antithrombin III--AT III, plasma tolerances to heparin--PTH), and fibrinolysis (lysis time of euglobulin clot--LTEC), enzyme condition of antiradical protection--superoxide scavenger (SOSC) which reduction in concentration leads to increase in concentration of malonic dialdehyde (MD) in erythrocytes (Er), thrombocytes (Tr), blood plasma (BP) in patients with acute virus myocarditis (AVM) of all severity groups and statistically correlate with the degree of severity of clinical course and demands medication correction.

[State of physiological anticoagulant heparin, antithrombin III and their correction with medicines in patients with acute viral myocarditis].

For the first time, positive influence was shown of a complex blood heparin-antitrombin III on the state of the coagulant and fibrinolytic system of blood in patients with acute virus myocarditis that favours the normalization of clinical and laboratory indicators, improvement of the state of patients and reduction of average bed-day indicator (hospital stay) till 25 and 35 days in accordance with severity of clinical course of the disease and can be recommended as a choice of medicine.

[Total index of thrombocyte aggregation in patients with an acute viral myocarditis].

For the first time it is proved, that patients with an acute virus myocarditis have statistically confirmed authentic reduction in quantity of thrombocytes, extention of parameters of a activated partial thrombin time, reduction in concentration of a heparin-antithrombin III (AT-III) complex against suppressed enzyme of antiradical protection - superoxide dismutase and it has led to activization of a malonic dialdehyde in erythrocytes, thrombocytes and blood serum. In case of the development of an acute virus infection especially caused cardiotrophic strain Consaki, virus CVB 1-CVB 4, thrombocytes, according to P. Nemetchek-Gansler, acquire not pertaining to them ability for phagocytosis of viruses with following reduction in quantity of thrombocytes and increase in aggregation abilities of thrombocytes what influence the state of duration index of contact aggregation of thrombocytes with the tendency to shorten this duration, and also it may develop hypoxia, an ischemia and the subsequent necrosis of cardiomyocytes, that is to an acute virus myocarditis that demands corresponding correction with medications.

[Index state of contact platelet activation in patients with acute viral myocarditis].

The article shows that ISCART statistically correlates with the degree of severity of acute virus myocarditis. The authors proposed for the first time the group of medications and proved that efficiency of these medications correlates with the degree of severity of the disease and has a place to be used by physicians.

[First and second wave of the aggregation of platelets in patients with acute virus myocarditis and its treatment].

The author carried out an analysis of first and second wave of the aggregation of platelets in patients with acute virus myocarditis in connection with the stage of clinical course of the disease and therapy done.

[Interaction of ambulatory service, endocrinologic inpatient care and specialized departments in the treatment of patients with diabetes mellitus and foot lesions]. / Vzaiemodiia ambulatornoï sluzhby, endokrynolohichnoho statsionaru ta spetsializovanykh viddilen' v likuvanni khvorykh na tsukrovyi diabet z urazhenniam stopy.

Three-year experience of management and treatment of 3553 patients with diabetes mellitus (DM), including 500--insulindependent and 3053--insulinindependent cases, was summarized. Divisional endocrinologist is choosing patients with DM and high risk of the diabetic foot syndrome (DFS) or its signs. In presence of risk factors for DFS occurrence the patient is trained to care of foot and petty surgical manipulations are performed: to cut off toenails, treatment of superficial affection of skin and fungous affection of skin, determination of the foot setting, correcting insole to fit footwear if necessary. If all kinds of sensitivity are reduced on the foot in the absence of its deformity and ulcer the patient is recommended once a year to treat in endocrinological stationary and to consult surgeon in Centre of treatment of DM complications. If the foot blood supply is disordered, ulcer occurrs the patient is referred to surgeon. In 2132 (60%) patients risk factors or DFS signs were revealed. Surgical treatment for purulent-necrotic affection was conducted in 61 patients (2.9% of the patients number with risk factors of the foot affection), including intervention on the foot--in 50 (2.3%), high amputation of lower extremity--in 11 (0.6%).