[High performance liquid chromatography and radioimmunoassay in analysis of serum hydrocortisone concentration and pharmacokinetic parameters of glucocorticoids in human. The choice of method for clinical practice]. / Vysokoéffektivnaia zhidkostnaia khromatografiia i radioimmunologicheskii analiz v opredelenii kontsentratsii kortizola i farmakokineticheskikh pokazatelei gliukokortikoidov v syvorotke krovi cheloveka. Vybor metoda v klinicheskoi praktike.

Serum hydrocortisone concentrations were measured by high performance liquid chromatography (HPLC) and radioimmunoassay (RIA) in 24 children with different diseases and 16 healthy adults. HPLC and RIA proved to be equally sensitive. However the authors recommend HPLC as a reliable, rapid, and ecologically pure method, which is, in addition, selective and economic.

[Regulation of the water-electrolyte balance during neurosurgical operations with balanced anesthesia using sodium oxybutyrate]. / O reguliatsii vodno-élektrolitnogo obmena pri neirokhirurgicheskikh operatsiiakh v usloviiakh sbalansirovannoi anestezii oksibutiratom natriia.

Water-electrolyte homeostasis and its basic regulatory hormones have been studied in 36 patients with neurosurgical brain pathology during surgical interventions performed under balanced anesthesia (sodium hydroxybutyrate combined with NLA drugs). The study has revealed 3 types of reactions in hormones regulating water-electrolyte homeostasis: type I--a decrease in vasopressin (VP) concentration and renin-angiotensin-aldosterone system (RAAS) activity; type II--VP increase and RAAS activation; type III--an increase in VP content and RAAS disbalance. It has been shown that type I reaction is accompanied by marked osmotic disturbances. The impact of sodium hydroxybutyrate on RAAS is manifested in aldosterone secretion suppression.