1.
Bull Exp Biol Med
; 161(3): 414-8, 2016 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27496036
RESUMO
Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.