RESUMO
OBJECTIVES: The liver pretransplant phase requires the interaction of -multidisciplinary teams for optimal patient outcomes, including dental -professionals. In this study, we sought to estimate the prevalence of complications related to dental extraction in liver transplant candidates. MATERIAL AND METHODS: This study is a case series of patients eligible for liver transplants referred for dental treatment between 2012 and 2014. Eligible patients for this study underwent at least one tooth extraction, had a complete blood count at the time of the procedure, and were candidates for liver transplantation. RESULTS: Forty-three patients, 12 women (28%) and 31 men (72%), with an -average age of 50.9 ± 11.4 years, had received a total of 116 dental extractions. The prevalence of postoperative complications was 1.7% including two bleeding episodes in the same patient. Seven patients presented a platelet count below 50 × 10³/µL and received platelet transfusions preoperatively. CONCLUSIONS: Postoperative complications following dental extractions in liver transplant candidates are unusual. CLINICAL RELEVANCE: Low postoperative complications prevalence indicates that dental surgical procedures may be safety performed in patients eligible for liver transplantation after careful -preoperative evaluation.
Assuntos
Hepatopatias/complicações , Complicações Pós-Operatórias/epidemiologia , Extração Dentária , Brasil/epidemiologia , Feminino , Humanos , Hepatopatias/epidemiologia , Hepatopatias/cirurgia , Transplante de Fígado , Masculino , Pessoa de Meia-Idade , PrevalênciaRESUMO
Although interleukin-17 (IL-17) is a recently discovered cytokine associated with several autoimmune diseases, its role in the pathogenesis of chronic graft-versus-host disease (cGVHD) was not established yet. The objective of this study was to investigate the association of IL17A and IL17F genes polymorphisms and IL-17A and IL-17F levels with cGVHD. IL-17A expression was also investigated in CD4(+) T cells of patients with systemic cGVHD. For Part I of the study, fifty-eight allo-HSCT recipients and donors were prospectively studied. Blood samples were obtained to determine IL17A and IL17F genes polymorphisms. Cytokines levels in blood and saliva were assessed by ELISA at days +35 and +100 after HSCT. In Part II, for the immunophenotypic evaluation, eight patients with systemic cGVHD were selected and the expression of IL-17A was evaluated. We found association between recipient AA genotype with systemic cGVHD. No association was observed between IL-17A levels and cGVHD. Lower IL-17A levels in the blood were associated with AA genotype. In flow cytometry analysis, decreased expression of IL-17A was observed in patients with cGVHD after stimulation. In conclusion, IL-17A may have an important role in the development of systemic cGVHD.
Assuntos
Doença Enxerto-Hospedeiro/genética , Interleucina-17/genética , Adolescente , Adulto , Criança , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Citometria de Fluxo , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético/genética , Adulto JovemRESUMO
A godiva, um material muito utilizado para moldagem de áreas edentadas, é um composto termoplástico que atinge viscosidade e fluidez ideiais para esse fim em torno de 54ºC. Em clínicas, consultórios e escolas de Odontologia, a godiva é aquecida em plasticizadores que, da forma como säo utilizados, podem tornar-se reservatórios de agentes infecciosos. Para eliminar o risco de infecçäo cruzada, testamos se a godiva mostra boa plasticidade quando aquecida pela irradiaçäo de dois modelos de microondas com capacidades diferentes