RESUMO
Concrete Outdoor Runs (OUTRUNs) are a characteristic part of organic pig housing. They must allow species-specific behaviours such as rooting and elimination, as explicitly required by organic legislation of the European Union (EU). However, OUTRUN design often fails to fulfil behavioural needs, and excreta can cover large parts of the OUTRUN leading to poor pen hygiene and associated ammonia (NH3) emissions. This review integrates legislative, ethological and environmental requirements for OUTRUNs for organic growing-finishing pigs. While EU regulations specify some welfare-related standards for OUTRUNs (e.g. minimal space allowance), national and private standards interpret some aspects differently, e.g. the proportion of roofed and slatted floor area. Furthermore, reducing NH3 emissions is equally a challenge for organic systems, even though EU legislation does not explicitly refer to OUTRUNs. Depending on the actual use of the OUTRUN for elimination, higher space allowance compared to conventional production norms increases the potential for a large NH3-emitting surface. The design of pen features (e.g. roof, floor, enrichment) can encourage pigs to separate functional areas and consequently reduce the elimination area and associated NH3 emissions. While providing the main lying area indoors, resting outdoors should be possible for sub-groups during the day. A roof protects pigs and resources (e.g. bedding) from adverse weather, but the effect on pig welfare and NH3 emissions is site-specific. A floor design that ensures practicable manure removal and drainage is most important to reduce emissions. Providing opportunities for exploring and rooting in the OUTRUN has particular relevance for pigs' behavioural needs and can improve pen hygiene by reducing the elimination area. Cooling facilities are increasingly important to prevent heat stress and its detrimental effects on welfare and pen hygiene. Finally, practicability for farmers needs to be ensured for all resources provided in OUTRUNs, as good management is crucial. Research gaps emerge regarding the association between soiling and NH3 and the influence of certain pen features (shape, roof, feeder location, pen partitions and wet areas) on pig behaviour and soiling.
Assuntos
Criação de Animais Domésticos , Abrigo para Animais , Amônia/análise , Animais , Pisos e Cobertura de Pisos , Esterco , SuínosRESUMO
Antibiotic treatment of native osteomyelitis caused by extended-spectrum ß-lactamase-producing Enterobacterales (ESBL-PE) is a challenge. Limited epidemiological and outcome data are available. This retrospective cohort study included osteomyelitis patients with ESBL-PE infections treated in a reference centre for bone and joint infections (BJIs) between 2011-2019. Twenty-nine patients with native BJI (mean age, 44.4 ± 15.7 years) were analysed. Fifteen cases were paraplegic patients with ischial pressure sores breaching the hip capsule. Other cases included eight other hip infections, four tibial infections and two foot infections. Infections were mostly polymicrobial (n = 23; 79.3%), including Staphylococcus aureus (n = 13; 8 methicillin-resistant). Klebsiella pneumoniae (n = 13) was the most frequent ESBL-producing species identified, followed by Escherichia coli (n = 10), including 3 E. coli/K. pneumoniae co-infections, and Enterobacter spp. (n = 9). ESBL-PE were rarely susceptible to fluoroquinolones (n = 4; 13.8%). Most therapies were based on carbapenems (n = 22) and combination therapies (n = 19). The median duration of treatment was 41 (5-60) days. Primary control of the infection was achieved in 62.1% (18/29) of cases and up to 86.2% after second look surgeries, after a median follow-up of 6 (1-36) months. Infection with ESBL-producing K. pneumoniae was associated with failure (P = 0.001), whereas age, infection location, prior colonisation and antimicrobial therapy were not found to be predictors of outcome. ESBL-PE native BJIs are often polymicrobial and fluoroquinolone-resistant infections caused by K. pneumoniae, highlighting the need for expert centres with pluridisciplinary meetings with experienced surgeons.
Assuntos
Antibacterianos/uso terapêutico , Osso e Ossos/fisiopatologia , Infecções por Enterobacteriaceae/tratamento farmacológico , Enterobacteriaceae/metabolismo , Articulações/fisiopatologia , Osteomielite/tratamento farmacológico , beta-Lactamases/metabolismo , Adulto , Idoso , Osso e Ossos/microbiologia , Doenças Transmissíveis/diagnóstico , Doenças Transmissíveis/tratamento farmacológico , Infecções por Enterobacteriaceae/diagnóstico , Feminino , Humanos , Articulações/microbiologia , Masculino , Pessoa de Meia-Idade , Osteomielite/diagnóstico , Paris , Estudos Retrospectivos , Resultado do TratamentoRESUMO
INTRODUCTION: Pancreatic surgery is associated with high morbidity, mainly due to infectious complications, so many centres use postoperative antibiotics (ATBpo) for all patients. However, antibiotic regimens vary according to local practices. The aims of this study were to describe the occurrence of surgical site infection (SSI) and ATBpo prescription after pancreatic surgery, and to determine the risk factors of postoperative SSI, in order to better define the clinical indications for ATBpo in this context. PATIENTS AND METHODS: All patients undergoing scheduled major pancreatic surgery from January 2007 to November 2018 were included in this retrospective study. Patients were classified into four groups according to SSI and routine ATBpo prescription: SSI+/ATBpo+, SSI-/ATBpo+, SSI+/ATBpo- and SSI-/ATBpo-. In addition, risk factors (fever and pre-operative biliary prosthesis) associated with the occurrence of SSI and ATBpo were analysed using a logistic regression model. RESULTS: Data from 149 patients (115 pancreaticoduodenectomies and 34 splenopancreatectomies) were analysed. Thirty (20.1%) patients experienced SSI and 42 (28.2%) received ATBpo. No difference was found in routine ATBpo prescription between patients with and without SSI (26.7% vs 28.6%, respectively; P=0.9). Amongst the 107 patients who did not receive routine ATBpo, 85 (79.4%) did not develop an SSI. In-hospital mortality did not differ between infected and uninfected patients (7% vs 2%, respectively; P=0.13). The occurrence of postoperative fever differed between SSI+ and SSI- patients (73.3% vs 34.2%, respectively; P<0.001), while the prevalence of pre-operative biliary prosthesis was similar (37.9% vs 26.7%, respectively; P=0.3). CONCLUSION: Non-routine ATBpo after major pancreatic surgery resulted in 85 (56%) patients being spared unnecessary antibiotic treatment. This suggests that routine ATBpo prescription could be excessive, but further studies are needed to confirm such antibiotic stewardship. Fever appears to be a relevant clinical sign for individual-based prescription, but the presence of a biliary prosthesis does not.
Assuntos
Antibioticoprofilaxia , Gestão de Antimicrobianos , Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Infecção da Ferida Cirúrgica , Antibacterianos/uso terapêutico , Humanos , Pâncreas/cirurgia , Estudos Retrospectivos , Fatores de Risco , Infecção da Ferida Cirúrgica/tratamento farmacológicoRESUMO
OBJECTIVES: Limited data have been reported regarding osteomyelitis due to carbapenemase-producing Enterobacteriaceae (CPE), including co-infections with extended-spectrum ß-lactamase (ESBL)-producing micro-organisms. METHODS: We conducted a retrospective study in a reference centre for bone and joint infections from 2011 to 2019 among patients infected with CPE. RESULTS: Nine patients (mean age 46.8 ± 16.6 years), including three with infected implants, were identified. Infections were mostly polymicrobial (n = 8/9), including Staphylococcus aureus (n = 6/9). CPE were mainly OXA-48-type, associated with ESBL-producing Enterobacteriaceae (n = 8/9), of which 5/9 isolates were Klebsiella pneumoniae. Control of the infection was achieved in seven cases. CONCLUSIONS: CPE osteomyelitides are essentially polymicrobial and fluoroquinolone-resistant infections, highlighting the need for efficient surgery with implant removal.
Assuntos
Enterobacteriáceas Resistentes a Carbapenêmicos , Infecções por Enterobacteriaceae , Osteomielite , Adulto , Proteínas de Bactérias/genética , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , beta-Lactamases/genéticaRESUMO
OBJECTIVES: Veillonella parvula is an anaerobic Gram-negative coccus rarely involved in bone and joint infections. PATIENTS AND METHOD: We report the case of a Veillonella parvula vertebral osteomyelitis (VO) in a female patient without any risk factor. RESULTS: The 35-year-old patient was immunocompetent and presented with Veillonella parvula VO. She was admitted to hospital for inflammatory lower back pain. The discovertebral sample was positive for Veillonella parvula. Literature data on Veillonella VO is scarce. Reported cases usually occurred in immunocompromised patients. Diagnosis delay can be up to four months. Patients are usually afebrile. Outcome with antimicrobial treatment alone is favorable in half of cases. Other patients must undergo surgery. CONCLUSIONS: Veillonella VO may occur in immunocompetent patients and have a clinical spectrum of mechanical lower back pain.
Assuntos
Discite/diagnóstico , Infecções por Bactérias Gram-Negativas/diagnóstico , Vértebras Lombares/microbiologia , Veillonella , Adulto , Discite/microbiologia , Feminino , Infecções por Bactérias Gram-Negativas/microbiologia , Humanos , Imunocompetência , Osteomielite/diagnóstico , Osteomielite/microbiologia , Veillonella/isolamento & purificação , Veillonella/fisiologiaRESUMO
In an anonymous 4-person economic game, participants contributed more money to a common project (i.e., cooperated) when required to decide quickly than when forced to delay their decision (Rand, Greene & Nowak, 2012), a pattern consistent with the social heuristics hypothesis proposed by Rand and colleagues. The results of studies using time pressure have been mixed, with some replication attempts observing similar patterns (e.g., Rand et al., 2014) and others observing null effects (e.g., Tinghög et al., 2013; Verkoeijen & Bouwmeester, 2014). This Registered Replication Report (RRR) assessed the size and variability of the effect of time pressure on cooperative decisions by combining 21 separate, preregistered replications of the critical conditions from Study 7 of the original article (Rand et al., 2012). The primary planned analysis used data from all participants who were randomly assigned to conditions and who met the protocol inclusion criteria (an intent-to-treat approach that included the 65.9% of participants in the time-pressure condition and 7.5% in the forced-delay condition who did not adhere to the time constraints), and we observed a difference in contributions of -0.37 percentage points compared with an 8.6 percentage point difference calculated from the original data. Analyzing the data as the original article did, including data only for participants who complied with the time constraints, the RRR observed a 10.37 percentage point difference in contributions compared with a 15.31 percentage point difference in the original study. In combination, the results of the intent-to-treat analysis and the compliant-only analysis are consistent with the presence of selection biases and the absence of a causal effect of time pressure on cooperation.
Assuntos
Comportamento Cooperativo , Heurística , Relações Interpessoais , Tomada de Decisões , Humanos , Intenção , Modelos PsicológicosRESUMO
Actinobaculum schaalii is an emerging pathogen particularly involved in urinary tract infection of elderly people and/or patient with urological risk factors of urinary tract infection. This microorganism is a difficult-to-diagnose pathogen and is rarely involved in systemic or deep infections. Here, we report the first case of prosthetic joint infection due to A. schaalii in an 84-year-old man with a benign prostatic hyperplasia associated with chronic retention of urine. This case underlines the importance to optimize the diagnosis of emerging uropathogens as A. schaalii, to prevent systemic infections, particularly in patients with orthopaedic implants.
Assuntos
Actinomycetaceae , Infecções por Actinomycetales , Prótese do Joelho/efeitos adversos , Infecções Relacionadas à Prótese , Actinomycetaceae/efeitos dos fármacos , Actinomycetaceae/isolamento & purificação , Idoso de 80 Anos ou mais , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Humanos , MasculinoRESUMO
At monolayer coverage, silicene on Ag(1 1 1) may present different structural phases depending on the growth conditions. At multilayer coverage, only one structural phase has been reported: the [Formula: see text] phase. However, no link between the structural arrangement of the monolayer and that of the multilayer has been addressed. In this paper, reporting experimental work based on low-energy electron diffraction and scanning tunneling microscopy, we focus on the structural aspects of a multilayer film of silicene. We demonstrate that it exhibits one structural arrangement, namely the [Formula: see text] form, but with different domain orientations resulting from the structural properties of the initial wetting monolayer.
Assuntos
Grafite/química , Silício/química , Difusão , Elétrons , Prata/química , Propriedades de SuperfícieRESUMO
AIM: The aims of this study were to assess the age limit for infiltration anaesthesia as an effective technique in treating carious lesions of first permanent molars in the paediatric age and if differences exist between males and females. MATERIALS AND METHODS: A total of 51 teeth from 48 different patients aged between 6 and 14 years were included in the study. The anaesthetic solution used was 1.8 ml of 2% mepivacaine with 1:100000 epinephrine. The effectiveness of anaesthesia was assessed by electrical pulp test after 3, 5, 7 and 10 minutes. RESULTS: In 56.9% of the treated cases a single mandibular infiltration was sufficient to induce complete pulpal anaesthesia of the tooth to be treated. Under 10 years of age, the infiltration technique was effective in 85.2% of cases. The success rate of anaesthesia also decreased significantly and not linearly in function of age. The success of infiltration anaesthesia was not related to gender. CONCLUSION: Mandibular infiltration anaesthesia is a successful technique for most patients under 10 years (success rate: 85.2%) especially for the younger ones, with no differences between males and females. After this age that success rate dramatically drops.
Assuntos
Anestesia Local/estatística & dados numéricos , Anestésicos Locais/administração & dosagem , Restauração Dentária Permanente/métodos , Mepivacaína/administração & dosagem , Adolescente , Fatores Etários , Distribuição de Qui-Quadrado , Criança , Cárie Dentária/terapia , Preparo da Cavidade Dentária , Teste da Polpa Dentária , Relação Dose-Resposta a Droga , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Nervo Mandibular , Dente Molar , Fatores Sexuais , Estatísticas não ParamétricasRESUMO
This study investigated how well organic growing-fattening pig systems provided a safe and healthy working environment and identified areas where improvements are needed. The study formed part of a larger project aimed at identifying strategies for creating a good animal and working environment and resource-efficient nutrient management in outdoor pig systems. Field studies were carried out at six Swedish farms in two types of outdoor pig systems (mobile and stationary). A method known as WEST (Work Environment Screening Tool) and a modified version of WEST, called WEST-agriculture (WEST-AG), were utilized for screening. Together, the two methods covered six factors of the working environment. The results were expressed in WEST-AG points and WEST points, an economic measure of the risk of impacts on health and productivity expressed as Swedish Krona (SEK) per thousand working hours. The results demonstrated that the risk of injury and ergonomic load during manual feeding and watering was much higher than during semi-automatic feeding and watering at farms with the mobile system. The study also identified other health-risk areas and provided valuable information for further improvement of the working environment in different outdoor pig systems.
Assuntos
Criação de Animais Domésticos/métodos , Ergonomia/estatística & dados numéricos , Programas de Rastreamento , Doenças Musculoesqueléticas/prevenção & controle , Exposição Ocupacional/prevenção & controle , Saúde Ocupacional , Adulto , Criação de Animais Domésticos/normas , Criação de Animais Domésticos/estatística & dados numéricos , Animais , Ergonomia/psicologia , Alimentos Orgânicos , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Musculoesqueléticas/epidemiologia , Doenças Musculoesqueléticas/etiologia , Exposição Ocupacional/efeitos adversos , Fatores de Risco , Suécia , Suínos , Local de Trabalho , Ferimentos e Lesões/epidemiologia , Ferimentos e Lesões/prevenção & controle , Ferimentos e Lesões/psicologiaRESUMO
Advances in the medical treatment of HIV have made it clear that adherence to highly active antiretroviral treatment is a crucial feature for treatment success. The present paper had two goals: (1) to examine psychosocial predictors of adherence in persons receiving HIV antiretroviral therapy; (2) to compared two minimal-treatment interventions to increase HIV medication adherence in a subset of persons who self-reported less than perfect adherence. One of the interventions, Life-Steps, is a single-session intervention utilizing cognitive-behavioral, motivational interviewing, and problem-solving techniques. The other intervention, self-monitoring, utilizes a pill-diary and an adherence questionnaire alone. Significant correlates of adherence included depression, social support, adherence self-efficacy, and punishment beliefs about HIV. Depression was a significant unique predictor of adherence over and above the other variables. Both interventions yielded improvement in adherence from baseline, and the Life-Steps intervention showed faster improvements in adherence for persons with extant adherence problems.
Assuntos
Fármacos Anti-HIV/administração & dosagem , Terapia Comportamental/métodos , Monitoramento de Medicamentos , Infecções por HIV/tratamento farmacológico , Cooperação do Paciente/psicologia , Adulto , Fármacos Anti-HIV/efeitos adversos , Terapia Cognitivo-Comportamental/métodos , Feminino , Infecções por HIV/psicologia , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Fatores de Risco , Autocuidado/psicologia , Resultado do TratamentoRESUMO
This paper concerns various aspects of the hemispheric contribution to the emotions formation.
Assuntos
Afeto/fisiologia , Encéfalo/fisiologia , Lateralidade Funcional/fisiologia , HumanosRESUMO
This paper is part of a wider comparative study of the heart rate, blood pressure, external and core temperature in operators of self-propelled mining machines with and without air-conditioning cabins. Two groups, each of ten operators, characterised by the similar age and duration of employment, stayed for 20 min a specially prepared resting chamber with much more advantageous microclimatic conditions. The results of our examinations (Holter heart rate and continuous blood pressure recordings, external and core temperature measurements) revealed that during the work (particularly during the increased work-load) all parameters recorded were significantly lower in air-conditioning cabins as compared with the group working without air-condition. In both groups, a complete restitution of the heart rate and blood pressure was observed after a 20-min stay in the resting chamber. During the work, a statistically significant increase in the external temperature was found in both groups of operators, whereas the increase in the core temperature was observed only in operators working without air-condition. After a 20-min stay in the resting chamber, a complete return to the normal temperature was noted only in operators working in air-conditioned cabins.
Assuntos
Ar Condicionado , Pressão Sanguínea , Monitoramento Ambiental , Frequência Cardíaca , Mineração , Adulto , Cobre , Eletrocardiografia Ambulatorial , Humanos , Pessoa de Meia-Idade , Local de TrabalhoRESUMO
Malignant mesotheliomas (MMs) are pleural-, pericardial-, or peritoneal-based neoplasms usually associated with asbestos exposure. Mesothelial cells are biphasic and may give rise to epithelial and sarcomatous MMs. In addition, benign or atypical proliferations of mesothelial cells may occur in response to many stimuli. There have been recent reports of simian virus 40 (SV40) DNA large T antigen (Tag) sequences in pleural MMs. To further understand the relationship between SV40, MMs, and mesothelial proliferations, we studied 118 MMs from multiple sites in Germany and North America, including 93 epithelial pleural, 14 sarcomatous or mixed pleural MMs, and 11 peritoneal MMs. In 12 pleural MMs, adjacent noninvasive tumor foci were identified and studied separately. Information about asbestos exposure (detailed history and/or microscopic examination for asbestos bodies) was available from 43 German patients. In addition, 13 examples of reactive mesothelium and 20 lung cancers from the United States were tested. DNA was extracted from frozen tumor and adjacent nontumorous tissues or after microdissection of archival formalin-fixed, paraffin-embedded microslides. Two rounds of PCR were performed with primers SVFor 3 and SVRev, which amplify a 105 bp region specific for SV40 Tag. The specificity of the PCR product was confirmed in some cases by sequencing. Our major findings were: 1) Specific SV40 viral sequences were present in 57% of epithelial invasive MMs, of both pleural and peritoneal origin. No significant geographic differences were found, and frozen and paraffin-embedded tissues were equally suitable for analysis. 2) There was no apparent relationship between the presence of SV40 sequences and asbestos exposure. 3) SV40 sequences were present in the surface (noninvasive) components of epithelial MMs. 4) SV40 sequences were not detected in MMs of sarcomatous or mixed histologies. 5) Viral sequences were present in two of 13 samples (15%) of reactive mesothelium. 6) Lung cancers lacked SV40 sequences, as did non-malignant tissues adjacent to MMs. Our findings demonstrate the presence of SV40 sequences in epithelial MMs of pleural and peritoneal origin and their absence in tumors with a sarcomatous component. Viral sequences may be present in reactive and malignant mesothelial cells, but they are absent in adjacent tissues and lung cancers.
Assuntos
Mesotelioma/virologia , Vírus 40 dos Símios/isolamento & purificação , Antígenos Transformantes de Poliomavirus/genética , Amianto/efeitos adversos , Divisão Celular , Epitélio/patologia , Epitélio/virologia , Humanos , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/virologia , Mesotelioma/patologia , Neoplasias Peritoneais/patologia , Neoplasias Peritoneais/virologia , Neoplasias Pleurais/patologia , Neoplasias Pleurais/virologia , Vírus 40 dos Símios/genéticaRESUMO
While testing neurotic patients it was noted that almost all of their complaints concerned physical weakness, easy tiredness, chest pain, heart beating and palpitation. In order to evaluate objectively their physical efficiency, the patients were subjected to exercise test on a treadmill, their ECG, HR and blood pressure being monitored. The exercise test was carried out twice, i.e. before and after 3-month psychotherapy. The average physical efficiency coefficient before treatment was significantly lower than after the treatment, but repolarization disorders were significantly higher before the treatment. ECG analysis proved non-specific repolarization changes induced by excitability of sympathetic system. 8 patients showed changes in ST-T before the treatment and 4 persons after it. Another kind of changes (that appeared in 14 cases before the treatment) were extrasystoles mainly supraventricular. After psychotherapy they were noted only in 1 case. The analysis of HR and blood pressure proved a significantly higher HR and lower blood pressure before the treatment. The obtained results may become an argument supporting the functional character of the changes mentioned.
Assuntos
Teste de Esforço , Transtornos Neuróticos/diagnóstico , Adulto , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Neuróticos/psicologia , Fatores de TempoRESUMO
Visual evoked potentials (VEPs) were recorded in a group of 20 operators aged 25-45 years during two sessions, before and after a 5-hour work at computer terminals, in order to assess visual system fatigue. The outcomes were referred to the norms established for the age-matched population of 30 subjects not exposed to professional contact with computers. Most of the examined operators suffered various complaints concerning not only the organ of vision but the central nervous system as well. VEPs were elicited by means of monocular stimulation using the reversal checkerboard pattern and recorded simultaneously from the scalp electrodes placed over the right and the left cerebral hemisphere. Only recording acquired after finishing of a working day demonstrated significant statistically abnormalities of the VEPs waveforms, which suggests their transient character. The changes mentioned above included prolongation of peaks P100 and N2 latency with concomitant attenuation of their amplitudes and a decrease of the correlation coefficient values for the recordings from the hemispheres. The preliminary findings presented in this paper seem to justify a conclusion that the non-invasive VEPs method can be considered as the objective indicator of the central visual fatigue induced by the workload at computer terminals.
Assuntos
Encéfalo/fisiologia , Computadores , Potenciais Evocados Visuais , Fadiga/diagnóstico , Fadiga/etiologia , Doenças Profissionais/diagnóstico , Doenças Profissionais/etiologia , Percepção Visual/fisiologia , Acomodação Ocular/fisiologia , Adulto , Eletrodos , Feminino , Lateralidade Funcional/fisiologia , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A goal of the present work was to analyze the correlation between a course of visual potentials elicited with the pattern stimulation and gender of the examined subjects. VEPs (Visual Evoked Potentials) recordings were performed using STELLA system in a group of 65 healthy adult subjects, with the age ranging from 18 to 70 years, consisting of the age-matched subgroups of 37 females and 28 males, applying a checkerboard as the pattern-reversal stimulation. In result of the analysis of the individual VEPs parameters, no effect of gender on the P100 latency was found. The discrepancies in the course of VEPs concerned P100 amplitudes, likewise a difference of the maximum and minimum amplitude, which proved to be significantly greater in the recordings collected from the left hemisphere in women than in men. Moreover, there was the appreciably greater symmetry between the responses registered over the both cerebral hemispheres, reflected by the higher correlation coefficients, in the male subgroup compared to the female subjects. The herein reported differences in the VEPs characteristics recorded in the male and female subjects can be elucidated on the ground of the documented discrepancies regarding the structural and functional cerebral organisation in women and men with regards to visual perception.
Assuntos
Potenciais Evocados Visuais , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores Sexuais , Visão Ocular/fisiologiaRESUMO
The study of simple reaction to light and sound, and differential reaction was carried out on the group of VDT operators (n = 62) and the group of persons not involved in VDT operation (n = 38). Concentration ability was tested with Couve's test twice a day, i.e. before and after work. In the analysis of the results, reaction time and the accuracy of psychomotor trials measured by the number of errors committed were considered. None of the research models disclosed statistically significant differences between the average figures calculated for the VDT operators and the other group. The figures registered before and after work in each group were not significant either. Both group also failed to show the influence of age on the duration of reaction. The ability to concentrate was lower among operators than among those not involved in VDT operation, and it decreased after work, especially in the oldest subgroup.
Assuntos
Astenopia/etiologia , Atenção/fisiologia , Terminais de Computador , Exposição Ocupacional , Ocupações , Tempo de Reação/fisiologia , Estresse Fisiológico/etiologia , Adulto , Astenopia/diagnóstico , Astenopia/fisiopatologia , Monitoramento Ambiental , Feminino , Humanos , Luz , Masculino , Pessoa de Meia-Idade , SomRESUMO
Previous experimental and clinical studies clearly demonstrated that exogenously administered CRH possesses respiratory properties. Until now, these effects were investigated using human (h) CRH in both healthy volunteers and patients under long-term respiration. We now compared the effects of hCRH with those of ovine (o) CRH in ten healthy young males. In particular it should be evaluated whether oCRH with its longer plasma half-life induces a more profound respiratory stimulation. On two separate days within two weeks, ventilation and cardiac performance were measured during steady state conditions by using a computerized cardio-pulmonary exercise testing system. In this placebo controlled double-blind-crossover study h- and oCRH (100 ug i.v. each) both augmented minute volume significantly during the observation period. Heart rate also increased after both analogues. All effects were comparable without a significant difference between both substances. There were no major side effects observable. Our data thus demonstrate that both analogues might be suitable for both diagnostic (i.e., testing of respiratory and autonomic responses) and therapeutic purposes.