RESUMO
Thymoxamine, a selective alpha-adrenergic blocker, was compared with pilocarpine in 19 patients for its reversal of phenylephrine-induced mydriasis. Both agents constricted the pupil to its original size in less than half an hour, and thymoxamine's half-life was twice that of pilocarpine's. The advantages of thymoxamine miosis, particularly in patients with narrow angles, are discussed.
Assuntos
Moxisilita/farmacologia , Fenilefrina/antagonistas & inibidores , Pilocarpina/farmacologia , Pupila/efeitos dos fármacos , Adulto , Idoso , Meia-Vida , Humanos , Pessoa de Meia-Idade , Fenilefrina/farmacologiaRESUMO
Thymoxamine, an alpha-adrenergic receptor blocking agent, was compared with pilocarpine in 11 patients for its effect on the depth of the anterior chamber. In the eyes treated with thymoxamine rapid and sustained miosis occurred without a significant change in the depth of the anterior chamber. On the other hand, the miosis induced by pilocarpine was accompanied by significant shallowing of the anterior chamber.
