RESUMO
Antifungal activity was tested in 49 pentacyclic triterpenoids and their glycosides, of plant and semisynthetic origin. Several of these compounds inhibited the multiplication of the yeast Saccharomyces carlsbergensis. The highest antifungal activity was found in the triterpene glycosides oleanolic acid and hederagenin, which have a free carboxyl group at C 28(27). Triterpenes of the meristotropic acid, macedonic acid, and lupan types had no fungistatic activity at concentrations up to 100 microgram/ml.
Assuntos
Antifúngicos , Saccharomyces/efeitos dos fármacos , Triterpenos/farmacologia , Antifúngicos/isolamento & purificação , Fenômenos Químicos , Química , Glicosídeos/farmacologia , Ácido Oleanólico/análogos & derivados , Ácido Oleanólico/isolamento & purificação , Ácido Oleanólico/farmacologia , Plantas/análise , Relação Estrutura-Atividade , Triterpenos/isolamento & purificaçãoRESUMO
Experiments were conducted on rats. A study was made of water, sodium, potassium and creatine excretion 3 hours after the administration into the stomach of a 5% load with a 0.9% NaCl solution. In comparison with control, sodium excretion decreased considerably in the animals given 2 mg per 100 g of weight of trioxylupane or heterobetulin; water, potassium and creatine excretion remained unchanged. Sodium and water excretion increased with administration of dioxylupenal in a dose of 2 mg per 100 g of weight. Heterobetulin also increased the urinary potassium excretion under conditions of administration to rats of a 5% load with a 1.25% KCl solution. The data obtained were of interest for the understanding of the interrelationship between the structure of the substances and their physiological activity.