1.
Antimicrob Agents Chemother
; 50(5): 1881-3, 2006 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16641468
RESUMO
We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.