RESUMO
Bacteria as a foreign pathogen can alter the physiology and metabolism of the host. Many of the teeth infecting bacteria known to be associated with obesity and diabetes in various organisms. The current study aims to check the effect of teeth infecting bacteria Enterobacter ludwigii on model organism Drosophila melanogaster. To check the effect, various concentrations of E. ludwigii on fly physiology the bacteria were added to the fly food. Flies were allowed to grow and colonise in infected food. The offsprings were checked for the accumulation of lipid and fat. With the increase of bacteria within the gut the amount of lipid and fat increases. Alongwith the fat various biochemical parameters like glucose, trehalose, protein and triglyceride level found to be altered. Within the fly gut various metals, which have a role in the metabolism is altered. However, during colonisation within the gut, the morphology of the bacteria remains unaltered. In the adult fly, all the biochemical parameters like glucose, trehalose, protein and triglyceride level increased. The expression level of Dilp is upregulated. Altogether, the current study reports an infection of E. ludwigii causes the accumulation of fat and alters glucose metabolism in Drosophila melanogaster.
