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Inflamm Allergy Drug Targets ; 13(2): 144-9, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24773332

RESUMO

BACKGROUND/PURPOSE(S): There is a growing interest in the targeting of Toll-like receptors (TLRs) for the treatment of allergic diseases. TLRs7/8 ligands are future candidates of therapeutic value in allergic rhinitis (AR). This study focus on TLRs7/8 ligand; resiquimod (R848) as an adjuvant to immunotherapy (IT) in AR patient. METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from atopic donors and non atopic donors. PBMCs were cultured in the absence and presence of date palm pollen allergen (Phoenix dactylifera; Pho d) and/or R848. Interleukin-4 (IL-4), IL-10, IL-13 and interferon gamma (IFN-γ) were measured in the culture supernatants. RESULTS: R848 was able to significantly increase the anti-inflammatory response in atopic donors more than non atopic donors. Nevertheless, the combination of both; R848 and Pho d provides inferior stimulus as compared to R848 alone in both atopic and non atopic donors. CONCLUSION: Invitro treatment of PBMCs with R484 hijacks the pro inflammatory immune process triggered by TLRs7/8 to mediate anti-inflammatory response. This may provide a conception about the activity and efficacy of TLRs7/8 ligands in AR and open the gate for them to be applied in clinically in humans.


Assuntos
Antialérgicos/farmacologia , Anti-Inflamatórios/farmacologia , Imidazóis/farmacologia , Rinite Alérgica Sazonal/tratamento farmacológico , Rinite Alérgica/tratamento farmacológico , Receptor 7 Toll-Like/agonistas , Receptor 8 Toll-Like/agonistas , Adulto , Alérgenos , Células Cultivadas , Citocinas/metabolismo , Feminino , Humanos , Mediadores da Inflamação/metabolismo , Masculino , Pessoa de Meia-Idade , Phoeniceae/imunologia , Proteínas de Plantas/imunologia , Pólen/imunologia , Rinite Alérgica/imunologia , Rinite Alérgica/metabolismo , Rinite Alérgica Sazonal/imunologia , Rinite Alérgica Sazonal/metabolismo , Receptor 7 Toll-Like/metabolismo , Receptor 8 Toll-Like/metabolismo
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