1.
Structure elucidation and antioxidant activity of (-)-isosilandrin isolated from Silybum marianum L.
Chem Biodivers
; 1(11): 1668-77, 2004 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17191807
RESUMO
A regioisomer of the known flavanolignan (-)-silandrin (3a), named (-)-isosilandrin (8a), was isolated from the fruits of a white-flowered variant of Silybum marianum L. populated in Hungary. Its structure was established both by spectroscopic methods and total synthesis, and its absolute configuration was determined by means of circular dichroism. This compound showed stronger inhibitory activity on the superoxide anion (O2*-) release by human polymorphonuclear leukocytes (PMNL) than (+)-silybin (1a,b).