Inflammasomes and the IL-1 Family in Bone Homeostasis and Disease.

PURPOSE OF REVIEW: Inflammasomes are multimeric protein structures with crucial roles in host responses against infections and injuries. The importance of inflammasome activation goes beyond host defense as a dysregulated inflammasome and subsequent secretion of IL-1 family members is believed to be involved in the pathogenesis of various diseases, some of which also produce skeletal manifestations. The purpose of this review is to summarize recent developments in the understanding of inflammasome regulation and IL-1 family members in bone physiology and pathology and current therapeutics will be discussed. RECENT FINDINGS: Small animal models have been vital to help understand how the inflammasome regulates bone dynamics. Animal models with gain or loss of function in various inflammasome components or IL-1 family signaling have illustrated how these systems can impact numerous bone pathologies and have been utilized to test new inflammasome therapeutics. It is increasingly clear that a tightly regulated inflammasome is required not only for host defense but for skeletal homeostasis, as a dysregulated inflammasome is linked to diseases of pathological bone accrual and loss. Given the complexities of inflammasome activation and redundancies in IL-1 activation and secretion, targeting these pathways is at times challenging. Ongoing research into inflammasome-mediated mechanisms will allow the development of new therapeutics for inflammasome/IL-1 diseases.

Facial psychophysiology in forensic investigation: A novel idea for deception detection.

BACKGROUND: Polygraph or lie detection test has been used since early 90s as an effective method in forensic investigations. However, polygraph does not have a stand-alone value in legal forums. Any novel scientific addition can strengthen the credibility of the polygraph. AIM: This study aims to determine whether the deception could be detected with the help of polygraph where electromyography (EMG) readings of the masseter muscle, along with electrocardiography and galvanic skin response, were considered. MATERIALS AND METHODS: The study was conducted on 14 participants in a well-established research setup. Card Test and Affirmative Test were performed on participants and the readings were critically analyzed. RESULTS: In both the tests performed, the deceptions were easily detected once and rarely detected twice. In some cases, the deceptions were undetected. CONCLUSION: The result indicated with minimal credence that EMG helps in detecting deception. The accuracy of detection however can be confirmed only after an extensive research.

Facial indices in lateral cephalogram for sex prediction in Chennai population - A semi-novel study.

BACKGROUND: Osteological examination is a very reliable tool to determine the sex of the individual as the consolidation of the dimorphic characteristics concludes the sex of the individual. This study was performed with lateral cephalograms, which is a vital diagnostic tool for patients undergoing orthodontic treatment. An index was formed, which could be considered as a reliable sex determinant in forensic applications. MATERIALS AND METHODS: This pilot study was performed on samples of the Dravidian population. Two-fifty individuals, whose age ranged between 25 and 40 years, were taken (125 subjects were males and 125 subjects were females). A total of ninety-nine cephalometric variables were compared, subjected to statistical analysis and tested for significance using the t-test. RESULTS: Out of a total of 99 variables tested only twenty-four variables showed statistical significance. So, these twenty-four variables were then subjected to discriminant function analysis to evaluate the effectiveness of each variable in predicting the sex of an individual Individually, Ramus length (Ramus ln), Condylion to Gnathion (Co-Gn) and ramus height showed the highest sex determining dependability of 78%. On the flipside, lower anterior facial height (LAFH), with 52%, showed the lowest consistency. CONCLUSION: From this study, it is clearly evident that cephalometric landmarks are reliable sex determinants to a good extent. All the statistically significant measurements, but one, showed acceptable percentages of reliability. This means the chosen variables can be used for the Dravidian population to robustly determine the sex of the individuals of interest.