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2.
Artigo em Russo | MEDLINE | ID: mdl-6538736

RESUMO

A change of excitability, pO2 and local cortical blood flow under a long-term maximum physical load and in conditions of experimental neurosis, was investigated in rabbits with electrodes implanted in the frontal cortex and ventromedial hypothalamus. It was found that functional activity of these structures under physical orverstrain rises as the blood flow and pO2 increase, and the excitability also increases. In experimental neurosis, a discoordination in functioning of the cortex and hypothalamus is observed. Relative stabilization of the functional state of tested structures, observed during physical overstrain, is absent in conditions of experimental neurosis.


Assuntos
Lobo Frontal/fisiologia , Hipotálamo Médio/fisiologia , Transtornos Neuróticos/fisiopatologia , Esforço Físico , Animais , Lobo Frontal/análise , Lobo Frontal/irrigação sanguínea , Humanos , Hipotálamo Médio/análise , Hipotálamo Médio/irrigação sanguínea , Oxigênio/análise , Coelhos
4.
Farmakol Toksikol ; 46(3): 20-3, 1983.
Artigo em Russo | MEDLINE | ID: mdl-6683200

RESUMO

It has been shown in experiments on rabbits with electrodes implanted into the brain that at the initial period of experimental neurosis formation chlorpromazine and diazepam produce a depressant action on the reduction of intracentral relations between the structures under study. Chlorpromazine favours the formation of additional positive relations whereas diazepam activates the formations of negative relations. At the final stages of experimental neurosis the drug effects become less appreciable.


Assuntos
Tonsila do Cerebelo/efeitos dos fármacos , Clorpromazina/uso terapêutico , Diazepam/uso terapêutico , Hipotálamo/efeitos dos fármacos , Transtornos Neuróticos/tratamento farmacológico , Animais , Avaliação Pré-Clínica de Medicamentos , Estimulação Elétrica , Eletroencefalografia , Humanos , Coelhos , Limiar Sensorial/efeitos dos fármacos , Estresse Psicológico/tratamento farmacológico , Fatores de Tempo
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